Expanding Horizons in Atherosclerosis Research : To Gotthard Schettler on His 70th Birthday

On 29 February 1964, a group of European scientists met in Paris to discuss a subject of common interest, namely atherosclerosis research, with particular reference to international communication and collaboration. After a second meeting on 15 May 1964, they founded the European Atherosclerosis Group which was to com­ prise individuals engaged in the various disciplines of atherosclero­ sis research in Eastern and Western Europe. Since then this group has initiated multidisciplinary discussion and scientific collabora­ tion across Europe, in accordance with the objects and aims written in its statutes: 1. To hold colloquia and symposia dealing with research in the field of atherosclerosis and allied sciences 2. To encourage meetings and exchanges between scientists in the group engaged in the investigation of atherosclerosis 3. To encourage collaborative work between national and interna­ tional centers engaged in atherosclerosis research 4. To encourage the publication of reviews, etc. , on atherosclerosis research which may be considered of value 5. To promote research fellowships, particularly for younger research workers, for studies within the field of atherosclerosis and allied sciences 6. To accept dues, endowments, grants, funds, and bequests to be used for the above purposes The European Atherosclerosis Group has helped to bring together what was separated during the second world war and the postwar period in Europe and to reestablish ties with the leading American teams. Front Matter....Pages I-XXI Front Matter....Pages 1-1 Pathogenesis of Atherosclerosis: — Current Status....Pages 3-12 The Extracellular Matrix of the Vessel Wall, Its Role and Modification During the Atherosclerotic Process....Pages 13-22 Changing Views of the Morphology of Atherosclerosis....Pages 23-26 Atherosclerosis as a Recurrent Cycle of Inflammation and Repair....Pages 27-38 Non-Arterial Deposition of Lipids and Lipoproteins: Significance in Relation to Atherogenesis....Pages 39-51 On the Role of Lipoprotein Antibody Immune Complexes in Atherogenesis....Pages 52-58 Role of Different Agents Affecting Endothelial Cells in the Process of Atherosclerosis — In Vitro Examinations....Pages 59-69 On the Delayed Experimental Pathologic Involvement of Cerebral Arteries in Hypercholesterolemic Monkeys, Rabbits and Spontaneously Hypertensive Rats....Pages 70-75 Enzyme-Acylalcohol-Alcohol Interactions in the Arterial Wall....Pages 76-81 The Effect of Balloon De-Endothelialization on Arterial Enzymes and Metabolic Intermediates in Rabbits....Pages 82-86 Front Matter....Pages 87-87 Coronary Heart Disease Epidemiology — Perspectives....Pages 89-95 Obesity and Cardiovascular Disease....Pages 96-101 Lipoproteins and Apolipoproteins in the Prediction of Coronary Artery Disease....Pages 102-113 Prevalence of Hyperlipidaemia in British Compared with North American Men....Pages 114-121 Low-Density Lipoprotein: Its Metabolic Determinants and Its Role in Coronary Heart Disease....Pages 122-125 Plasma Levels of Lipoproteins and Apolipoproteins in Octo- and Nonagenarians....Pages 126-131 Cholesteryl Ester Transfer, Lipoproteins, Hypertriglyceridemia, and Atherosclerosis....Pages 132-139 Importance of Hypertriglyceridemia as an Independent Risk Factor: Investigations with Familial Combined Hyperlipidemia and Familial Hypertriglyceridemia....Pages 140-146 The Plasma Lipoproteins in Hypertriglyceridemia as Risk Factors for Atherosclerosis....Pages 147-152 Myocardial Infarction in Women on Oral Contraceptives: Risk Factors and Mechanism....Pages 153-160 Front Matter....Pages 87-87 Combined Oral Contraceptives: From Risk to Benefit?....Pages 161-164 Bile Acids, Lipoproteins, and Atherosclerosis....Pages 165-172 Metabolic Abnormalities in Cerebral and Peripheral Arteriosclerosis....Pages 173-179 Elastase-Type Enzymes and Their Relation to Blood Lipids and Atherosclerosis....Pages 180-186 DNA Polymorphism for the Genetic Analysis of Atherosclerosis....Pages 187-194 Front Matter....Pages 195-195 Chylomicron Catabolism and Uptake by the Liver....Pages 197-203 Lipoprotein Lipase, Synthesis and Regulation....Pages 204-212 Structural and Clinical Aspects of the Plasma Phospholipid Subclasses....Pages 213-216 Irregular Working Hours and Lipid Levels in Men....Pages 217-224 Identification and Computer Modeling of Functional Domains in Plasma Apolipoproteins....Pages 225-235 New Perspectives in Human Apolipoprotein B Metabolism....Pages 236-241 Fish Eye Disease: Implications for the Understanding of Cardiovascular Disease and Plasma Lipoprotein Metabolism....Pages 242-248 Front Matter....Pages 249-249 Vascular Growth Factors and Atherogenesis in Diabetes Mellitus....Pages 251-259 Cholesterol Biosynthesis in Diabetes Mellitus....Pages 260-263 Effects of Diet Fat Composition on Serum Lipids and Lipoproteins in Patients with Insulin-Dependent Diabetes Mellitus....Pages 264-270 Front Matter....Pages 271-271 β 2 -Glycoprotein-I (Apolipoprotein H): Possible Role in Platelet Activation and Coagulation....Pages 273-280 Front Matter....Pages 281-281 Changes in Diet, Serum Cholesterol, and Mortality from Coronary Heart Disease in Spain....Pages 283-285 Modified Fat Diets and Serum Lipoproteins....Pages 286-292 Essential Fatty Acids, Marine Oils, Olive Oil and Coronary Heart Disease....Pages 293-298 What Are the Alpha-Linolenic Acid Supplies to Be Recommended to the Normal Adult?....Pages 299-303 Front Matter....Pages 281-281 Animal and Vegetable Protein Effects in Experimental Atherosclerosis....Pages 304-308 Food Proteins and Atherosclerosis....Pages 309-316 Cholesterol-Lowering and High-Density Lipoprotein-Raising Properties of Lecithinated Soy Proteins in Type II Hyperlipidemic Patients....Pages 317-320 Front Matter....Pages 281-281 From Theory to Practice: Community-Based Studies on the Prevention of Coronary Heart Disease....Pages 323-328 Regression of Atherosclerosis in Man....Pages 329-337 Plasma Exchange and Its Development in the Treatment of Familial Hypercholesterolemia....Pages 338-344 The HELP System: A Novel Technique for the Extracorporeal Treatment of Familial Hypercholesterolemia....Pages 345-351 Plasma Exchange for Severe Forms of Familial Hypercholesterolemia: 10 Years’ (23 Patient Years’) Experience....Pages 352-358