Exercise for Cardiovascular Disease Prevention and Treatment: From Molecular to Clinical, Part 1 (Advances in Experimental Medicine and Biology Book 999)

The book provides an intensive overview on exercise for cardiovascular disease prevention and treatment, from basic research to clinical practice. The volume firstly summarizes the acute and chronic response to exercise. Secondly, evidence for exercise as medicine for the heart based on clinical studies and basic research is summarized. Thirdly, molecular mechanisms mediating the beneficial effects of exercise including IGF-1-PI3K-AKT signalling, NO signalling, C/EBPB-Cited4 signalling, Non-coding RNAs, epigenetic regulators, mitochondria adaption and exosomes are presented. Finally, exercise dosing, prescription and future prospects are provided. This book will provide valuable reference for researchers in cell biology, physiology, as well as physician, physical therapist in cardiology, sport medicine, etc. Front Matter ....Pages i-vi Front Matter ....Pages 1-1 Physical Inactivity and the Economic and Health Burdens Due to Cardiovascular Disease: Exercise as Medicine (Mark Hamer, Gary O’Donovan, Marie Murphy)....Pages 3-18 Front Matter ....Pages 19-19 Acute and Chronic Response to Exercise in Athletes: The “Supernormal Heart” (Antonello D’Andrea, Tiziana Formisano, Lucia Riegler, Raffaella Scarafile, Raffaella America, Francesca Martone et al.)....Pages 21-41 The Effects of Exercise on Cardiovascular Biomarkers: New Insights, Recent Data, and Applications (Lin Che, Dong Li)....Pages 43-53 Acute and Chronic Exercise in Animal Models (Vu Thi Thu, Hyoung Kyu Kim, Jin Han)....Pages 55-71 Front Matter ....Pages 73-73 Structural, Contractile and Electrophysiological Adaptations of Cardiomyocytes to Chronic Exercise (A. Krzesiak, N. Delpech, S. Sebille, C. Cognard, A. Chatelier)....Pages 75-90 Formation of New Cardiomyocytes in Exercise (Liang Shen, Hui Wang, Yihua Bei, Dragos Cretoiu, Sanda Maria Cretoiu, Junjie Xiao)....Pages 91-102 Physical Exercise Can Spur Beneficial Neoangiogenesis and Microvasculature Remodeling Within the Heart – Our Salvation? (Michal Miko, Ivan Varga)....Pages 103-115 The Non-cardiomyocyte Cells of the Heart. Their Possible Roles in Exercise-Induced Cardiac Regeneration and Remodeling (Ivan Varga, Jan Kyselovič, Paulina Galfiova, Lubos Danisovic)....Pages 117-136 Front Matter ....Pages 137-137 Myocardial Infarction and Exercise Training: Evidence from Basic Science (Ivana C. Moraes-Silva, Bruno Rodrigues, Hélio J. Coelho-Junior, Daniele Jardim Feriani, Maria-Claudia Irigoyen)....Pages 139-153 Cardiac Ischemia/Reperfusion Injury: The Beneficial Effects of Exercise (Juliana Pereira Borges, Karine da Silva Verdoorn)....Pages 155-179 Experimental Evidences Supporting the Benefits of Exercise Training in Heart Failure (Marcelo H. A. Ichige, Marcelo G. Pereira, Patrícia C. Brum, Lisete C. Michelini)....Pages 181-206 Exercise Amaliorates Metabolic Disturbances and Oxidative Stress in Diabetic Cardiomyopathy: Possible Underlying Mechanisms (Ayman M. Mahmoud)....Pages 207-230 Cardiac Aging – Benefits of Exercise, Nrf2 Activation and Antioxidant Signaling (Madhusudhanan Narasimhan, Namakkal-Soorappan Rajasekaran)....Pages 231-255 Cardiac Fibrosis: The Beneficial Effects of Exercise in Cardiac Fibrosis (Jan Kyselovič, John J. Leddy)....Pages 257-268 Physical Exercise Is a Potential “Medicine” for Atherosclerosis (Jian Yang, Richard Y. Cao, Rongrong Gao, Qiongyao Mi, Qiying Dai, Fu Zhu)....Pages 269-286 Experimental Evidences Supporting Training-Induced Benefits in Spontaneously Hypertensive Rats (Gustavo S. Masson, Lisete C. Michelini)....Pages 287-306 Exercise Training in Pulmonary Hypertension and Right Heart Failure: Insights from Pre-clinical Studies (Daniel Moreira-Gonçalves, Rita Ferreira-Nogueira, Mário Santos, Ana Filipa Silva, Rita Ferreira, Adelino Leite-Moreira et al.)....Pages 307-324