Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications

ITAe, 2013. — 648 p. — ISBN: 9789535109891. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided. This new information will lead to efficacious treatment strategies for these tumors which remain a challenge. Angiogenesis and Tumor Invasion Brain Tumor Invasion and Angiogenesis Gliomas Biology: Angiogenesis and Invasion Hypoxia, Angiogenesis and Mechanisms for Invasion of Malignant Gliomas Brain Tumor-Induced Angiogenesis: Approaches and Bioassays Immunotherapy IGF-I Antisense and Triple-Helix Gene Therapy of Glioblastoma Using REMBRANDT to Paint in the Details of Glioma Biology: Applications for Future Immunotherapy Molecular Biology of Brain Tumors and Associated Therapeutic Implications From Gliomagenesis to Multimodal Therapeutic Approaches into High-Grade Glioma Treatment Dipeptidyl Peptidase-IV and Related Proteases in Brain Tumors Apoptotic Events in Glioma Activate Metalloproteinases and Enhance Invasiveness The Distribution and Significance of IDH Mutations in Gliomas Deregulation of Cell Polarity Proteins in Gliomagenesis Aquaporin. Midkine and Glioblastoma Porphyrin Synthesis from 5-Aminolevulinic Acid in Patients with Glioma Mechanisms of Aggressiveness in Glioblastoma: Prognostic and Potential Therapeutic Insights Novel Anticancer Agents A Rational for Novel Anti-NeuroOncology Drugs DNA-PK is a Potential Molecular Therapeutic Target for Glioblastoma MicroRNAs Evolvement of microRNAs as Therapeutic Targets for Malignant Gliomas MicroRNAs Regulated Brain Tumor Cell Phenotype and Their Therapeutic Potential Section 6 Pediatric Brain Tumors Carbonic Anhydrase IX in Adult and Pediatric Brain Tumors New Molecular Targets and Treatments for Pediatric Brain Tumors Radioresistance of Brain Tumors In silico Analysis of Transcription Factors Associated to Differentially Expressed Genes in Irradiated Glioblastoma Cell Lines Stem Cells Brain Tumor Sternness Nestin: Neural Stem/Progenitor Cell Marker in Brain Tumors A Dramatic Increase In Knowledge Regarding The Molecular Biology Of Brain Tumors Has Been Established Over The Past Few Years. In Particular Recent New Avenues Regarding The Role Of Stem Cells And Micrornas Along With Further Understanding Of The Importance Of Angiogenesis, Immunotherapy And Explanations For The Resistance Of The Tumors To Chemotherapeutic Agents And Radiation Therapy Has Been Developed. It Is Hopeful That This New Information Will Lead To Efficacious Treatment Strategies For These Tumors Which Remain A Challenge. In This Book A Review Of The Latest Information On These Topics Along With A Variety Of New Therapeutic Treatment Strategies With An Emphasis On Molecular Targeted Therapies Is Provided.