European Handbook of Neurological Management: Gilhus/European Handbook of Neurological Management

Evidence-based, peer reviewed, best practice management guidelines for neurologists Diagnosis is only part of the puzzle. Effective treatment is what your patients really want. The European Federation of Neurological Societies has been publishing management guidelines in the European Journal of Neurology for many years. Developed by a consensus approach, using graded evidence, and then fully peer reviewed, these guidelines provide gold-standard, best-practice guidance to the treatment of neurological disorders. They help bridge the gap between what is done and what should be done for patients with neurological disorders. The basic guidelines have been expanded with 'Recommendations' based on strong evidence and 'Good Practice Points' where only weaker evidence is available. The Guidelines in this volume include, amongst others: Neurostimulation therapy for neuropathic pain Molecular diagnosis for a range of neurological conditions Intravenous immunoglobulin in the treatment of neurological diseases Sleep disorders in neurodegenerative disorders and stroke Management of low-grade gliomas Treatment of miscellaneous idiopathic headache disorders The European Handbook of Neurological Management provides a thoroughly rounded and grounded approach to best-practice neurological management using evidence-based principles. Titles of related interest Cerebrovascular Ultrasound in Stroke Prevention, 2e Alexandrov (ed); ISBN 9781405195768 Parkinsons's Disease: Non-Motor and Non-Dopaminergic Features Olanow, Stocchi and Lang (eds); ISBN 9781405191852 Hyperkinetic Movement Disorders: Differential Diagnosis and Treatment Albanese and Jankovic (eds); ISBN 9781444333527Content: Chapter 1 Guidance for the Preparation of Neurological Management Guidelines by EFNS Scientific Task Forces: Revised Recommendations 2004 (pages 5–10): M. Brainin, M. Barnes, J?C. Baron, N. Gilhus, R. Hughes, K. Selmaj and G. Waldemar Chapter 2 Neurostimulation Therapy for Neuropathic Pain (pages 11–29): G. Cruccu, T. Z. Aziz, L. Garcia?Larrea, P. Hansson, T. S. Jensen, J.?P. Lefaucheur, B. A. Simpson and R. S. Taylor Chapter 3 Trigeminal Neuralgia Management (pages 31–49): G. Cruccu, G. Gronseth, J. Alksne, C. Argoff, M. Brainin, K. Burchiel, T. Nurmikko and J. M. Zakrzewska Chapter 4 Molecular Diagnosis of Neurogenetic Disorders: General Issues, Huntington's Disease, Parkinson's Disease and Dystonias (pages 51–60): H. F. Harbo, J. Finsterer, J. Baets, C. Van Broeckhoven, S. Di Donato, B. Fontaine, P. De Jonghe, A. Lossos, T. Lynch, C. Mariotti, L. Schols, A. Spinazzola, Z. Szolnoki, S. J. Tabrizi, C. Tallaksen, M. Zeviani, J?M. Burgunder and T. Gasser Chapter 5 Molecular Diagnosis of Mitochondrial Disorders (pages 61–72): J. Finsterer, H. F. Harbo, J. Baets, C. Van Broeckhoven, S. Di Donato, B. Fontaine, P. De Jonghe, A. Lossos, T. Lynch, C. Mariotti, L. Schols, A. Spinazzola, Z. Szolnoki, S. J. Tabrizi, C. Tallaksen, M. Zeviani, J?M. Burgunder and T. Gasser Chapter 6 Molecular Diagnosis of Ataxias and Spastic Paraplegias (pages 73–85): T. Gasser, J. Finsterer, J. Baets, C. Van Broeckhoven, S. Di Donato, B. Fontaine, P. De Jonghe, A. Lossos, T. Lynch, C. Mariotti, L. Schols, A. Spinazzola, Z. Szolnoki, S. J. Tabrizi, C. M. E. Tallaksen, M. Zeviani, J?M. Burgunder and H. F. Harbo Chapter 7 Molecular Diagnosis of Channelopathies, Epilepsies, Migraine, Stroke and Dementias (pages 87–96): J?M. Burgunder, J. Finsterer, Z. Szolnoki, B. Fontaine, J. Baets, C. Van Broeckhoven, S. Di Donato, P. De Jonghe, T. Lynch, C. Mariotti, L. Schols, A. Spinazzola, S. J. Tabrizi, C. Tallaksen, M. Zeviani, H. F. Harbo and T. Gasser Chapter 8 Molecular Diagnosis of Neurogenetic Disorders: Motoneuron, Peripheral Nerve and Muscle Disorders (pages 97–109): J?M. Burgunder, L. Schols, J. Baets, P. Andersen, T. Gasser, Z. Szolnoki, B. Fontaine, C. Van Broeckhoven, S. Di Donato, P. De Jonghe, T. Lynch, C. Mariotti, A. Spinazzola, S. J. Tabrizi, C. Tallaksen, M. Zeviani, H. F. Harbo and J. Finsterer Chapter 9 Intravenous Immunoglobulin in the Treatment of Neurological Diseases (pages 111–127): I. Elovaara, S. Apostolski, P. van Doorn, N. E. Gilhus, A. Hietaharju, J. Honkaniemi, I. N. van Schaik, N. Scolding, P. Soelberg Sorensen and B. Udd Chapter 10 Sleep Disorders in Neurodegenerative Disorders and Stroke (pages 129–143): P. Jennum, J. Santamaria Cano, C. Bassetti, P. Clarenbach, B. Hogl, J. Mathis, R. Poirrier, K. Sonka, E. Svanborg, L. Dolenc Grosel, D. Kaynak, M. Kruger, A. Papavasiliou and Z. Zahariev Chapter 11 Management of Community?Acquired Bacterial Meningitis (pages 145–157): A. Chaudhuri, P. Martinez?Martin, P. G. E. Kennedy, R. Andrew Seaton, P. Portegie,s, M. Bojar and I. Steiner Chapter 12 Diagnosis and Management of European Lyme Neuroborreliosis (pages 159–173): Ase Mygland, Unn Ljostad, Volker Fingerle, Tobias Rupprecht, Erich Schmutzhard and Israel Steiner Chapter 13 Disease?Specific Cerebrospinal Fluid Investigations (pages 175–197): F. Deisenhammer, R. Egg, G. Giovannoni, B. Hemmer, A. Petzold, F. Sellebjerg, C. Teunissen and H. Tumani Chapter 14 Neuroimaging in the Management of Motor Neuron Diseases (pages 199–211): M. Filippi, F. Agosta, S. Abrahams, F. Fazekas, J. Grosskreutz, S. Kalra, J. Kassubek, V. Silani, M. R. Turner and J. C. Masdeu Chapter 15 Management of Low?Grade Gliomas (pages 213–223): R. Soffietti, B. Baumert, L. Bello, A. von Deimling, H. Duffau, M. Frenay, W. Grisold, R. Grant, F. Graus, K. Hoang?Xuan, M. Klein, B. Melin, J. Rees, T. Siegal, A. Smits, R. Stupp and W. Wick Chapter 16 Treatment of Tension?Type Headache (pages 225–238): L. Bendtsen, S. Evers, M. Linde, D. D. Mitsikostas, G. Sandrini and J. Schoenen Chapter 17 Diagnosis, Therapy and Prevention of Wernicke's Encephalopathy (pages 239–252): R. Galvin, G. Brathen, A. Ivashynka, M. Hillbom, R. Tanasescu and M. A. Leone Chapter 18 Recommendations for the Diagnosis and Management of Spontaneous Intracerebral Haemorrhage (pages 253–277): T. Steiner, M. Kaste, M. Forsting, D. Mendelow, H. Kwiecinski, I. Szikora, S. Juvela, A. Marchel, R. Chapot, C. Cognard, A. Unterberg and W. Hacke Chapter 19 Diagnostic Approach to Pauci? or Asymptomatic hyperCKemia (pages 279–286): T. Kyriakides, C. Angelini, J. Schaefer, S. Sacconi, G. Siciliano, J. J. Vilchez and D. Hilton?Jones Chapter 20 Diagnosis and Management of Neuromyelitis Optica (pages 287–307): J. Sellner, M. Boggild, M. Clanet, R. Q. Hintzen, Z. Illes, X. Montalban, R. A. Du Pasquier, C. H. Polman, P. Soelberg Sorensen and B. Hemmer Chapter 21 Screening for Tumours in Paraneoplastic Syndromes (pages 309–320): M. J. Titulaer, R. Soffietti, J. Dalmau, N. E. Gilhus, B. Giometto, F. Graus, W. Grisold, J. Honnorat, P. A. E. Sillevis Smitt, R. Tanasescu, C. A. Vedeler, R. Voltz and J. J. G. M. Verschuuren Chapter 22 Treatment of Miscellaneous Idiopathic Headache Disorders (pages 321–335): S. Evers, P. Goadsby, R. Jensen, A. May, J. Pascual and G. Sixt Chapter 23 Treatment of Medication Overuse Headache (pages 337–344): S. Evers and R. Jensen **Evidence-based, peer reviewed, best practice management guidelines for neurologists** Diagnosis is only part of the puzzle. Effective treatment is what your patients really want. The European Federation of Neurological Societies has been publishing management guidelines in the __European Journal of Neurology__ for many years. Developed by a consensus approach, using graded evidence, and then fully peer reviewed, these guidelines provide gold-standard, best-practice guidance to the treatment of neurological disorders. They help bridge the gap between what is done and what should be done for patients with neurological disorders. The basic guidelines have been expanded with 'Recommendations' based on strong evidence and 'Good Practice Points' where only weaker evidence is available. The Guidelines in this volume include, amongst others: * Neurostimulation therapy for neuropathic pain * Molecular diagnosis for a range of neurological conditions * Intravenous immunoglobulin in the treatment of neurological diseases * Sleep disorders in neurodegenerative disorders and stroke * Management of low-grade gliomas * Treatment of miscellaneous idiopathic headache disorders The **__European Handbook of Neurological Management__** provides a thoroughly rounded and grounded approach to best-practice neurological management using evidence-based principles. **Titles of related interest**__Cerebrovascular Ultrasound in Stroke Prevention, 2e__Alexandrov (ed); ISBN 9781405195768 __Parkinsons's Disease: Non-Motor and Non-Dopaminergic Features__Olanow, Stocchi and Lang (eds); ISBN 9781405191852 __Hyperkinetic Movement Disorders: Differential Diagnosis and Treatment__Albanese and Jankovic (eds); ISBN 9781444333527Content: Chapter 1 Guidance for the Preparation of Neurological Management Guidelines by EFNS Scientific Task Forces: Revised Recommendations 2004 (pages 5–10): M. Brainin, M. Barnes, J?C. Baron, N. Gilhus, R. Hughes, K. Selmaj and G. WaldemarChapter 2 Neurostimulation Therapy for Neuropathic Pain (pages 11–29): G. Cruccu, T. Z. Aziz, L. Garcia?Larrea, P. Hansson, T. S. Jensen, J.?P. Lefaucheur, B. A. Simpson and R. S. TaylorChapter 3 Trigeminal Neuralgia Management (pages 31–49): G. Cruccu, G. Gronseth, J. Alksne, C. Argoff, M. Brainin, K. Burchiel, T. Nurmikko and J. M. ZakrzewskaChapter 4 Molecular Diagnosis of Neurogenetic Disorders: General Issues, Huntington's Disease, Parkinson's Disease and Dystonias (pages 51–60): H. F. Harbo, J. Finsterer, J. Baets, C. Van Broeckhoven, S. Di Donato, B. Fontaine, P. De Jonghe, A. Lossos, T. Lynch, C. Mariotti, L. Schols, A. Spinazzola, Z. Szolnoki, S. J. Tabrizi, C. Tallaksen, M. Zeviani, J?M. Burgunder and T. GasserChapter 5 Molecular Diagnosis of Mitochondrial Disorders (pages 61–72): J. Finsterer, H. F. Harbo, J. Baets, C. Van Broeckhoven, S. Di Donato, B. Fontaine, P. De Jonghe, A. Lossos, T. Lynch, C. Mariotti, L. Schols, A. Spinazzola, Z. Szolnoki, S. J. Tabrizi, C. Tallaksen, M. Zeviani, J?M. Burgunder and T. GasserChapter 6 Molecular Diagnosis of Ataxias and Spastic Paraplegias (pages 73–85): T. Gasser, J. Finsterer, J. Baets, C. Van Broeckhoven, S. Di Donato, B. Fontaine, P. De Jonghe, A. Lossos, T. Lynch, C. Mariotti, L. Schols, A. Spinazzola, Z. Szolnoki, S. J. Tabrizi, C. M. E. Tallaksen, M. Zeviani, J?M. Burgunder and H. F. HarboChapter 7 Molecular Diagnosis of Channelopathies, Epilepsies, Migraine, Stroke and Dementias (pages 87–96): J?M. Burgunder, J. Finsterer, Z. Szolnoki, B. Fontaine, J. Baets, C. Van Broeckhoven, S. Di Donato, P. De Jonghe, T. Lynch, C. Mariotti, L. Schols, A. Spinazzola, S. J. Tabrizi, C. Tallaksen, M. Zeviani, H. F. Harbo and T. GasserChapter 8 Molecular Diagnosis of Neurogenetic Disorders: Motoneuron, Peripheral Nerve and Muscle Disorders (pages 97–109): J?M. Burgunder, L. Schols, J. Baets, P. Andersen, T. Gasser, Z. Szolnoki, B. Fontaine, C. Van Broeckhoven, S. Di Donato, P. De Jonghe, T. Lynch, C. Mariotti, A. Spinazzola, S. J. Tabrizi, C. Tallaksen, M. Zeviani, H. F. Harbo and J. FinstererChapter 9 Intravenous Immunoglobulin in the Treatment of Neurological Diseases (pages 111–127): I. Elovaara, S. Apostolski, P. van Doorn, N. E. Gilhus, A. Hietaharju, J. Honkaniemi, I. N. van Schaik, N. Scolding, P. Soelberg Sorensen and B. UddChapter 10 Sleep Disorders in Neurodegenerative Disorders and Stroke (pages 129–143): P. Jennum, J. Santamaria Cano, C. Bassetti, P. Clarenbach, B. Hogl, J. Mathis, R. Poirrier, K. Sonka, E. Svanborg, L. Dolenc Grosel, D. Kaynak, M. Kruger, A. Papavasiliou and Z. ZaharievChapter 11 Management of Community?Acquired Bacterial Meningitis (pages 145–157): A. Chaudhuri, P. Martinez?Martin, P. G. E. Kennedy, R. Andrew Seaton, P. Portegie,s, M. Bojar and I. SteinerChapter 12 Diagnosis and Management of European Lyme Neuroborreliosis (pages 159–173): Ase Mygland, Unn Ljostad, Volker Fingerle, Tobias Rupprecht, Erich Schmutzhard and Israel SteinerChapter 13 Disease?Specific Cerebrospinal Fluid Investigations (pages 175–197): F. Deisenhammer, R. Egg, G. Giovannoni, B. Hemmer, A. Petzold, F. Sellebjerg, C. Teunissen and H. TumaniChapter 14 Neuroimaging in the Management of Motor Neuron Diseases (pages 199–211): M. Filippi, F. Agosta, S. Abrahams, F. Fazekas, J. Grosskreutz, S. Kalra, J. Kassubek, V. Silani, M. R. Turner and J. C. MasdeuChapter 15 Management of Low?Grade Gliomas (pages 213–223): R. Soffietti, B. Baumert, L. Bello, A. von Deimling, H. Duffau, M. Frenay, W. Grisold, R. Grant, F. Graus, K. Hoang?Xuan, M. Klein, B. Melin, J. Rees, T. Siegal, A. Smits, R. Stupp and W. WickChapter 16 Treatment of Tension?Type Headache (pages 225–238): L. Bendtsen, S. Evers, M. Linde, D. D. Mitsikostas, G. Sandrini and J. SchoenenChapter 17 Diagnosis, Therapy and Prevention of Wernicke's Encephalopathy (pages 239–252): R. Galvin, G. Brathen, A. Ivashynka, M. Hillbom, R. Tanasescu and M. A. LeoneChapter 18 Recommendations for the Diagnosis and Management of Spontaneous Intracerebral Haemorrhage (pages 253–277): T. Steiner, M. Kaste, M. Forsting, D. Mendelow, H. Kwiecinski, I. Szikora, S. Juvela, A. Marchel, R. Chapot, C. Cognard, A. Unterberg and W. HackeChapter 19 Diagnostic Approach to Pauci? or Asymptomatic hyperCKemia (pages 279–286): T. Kyriakides, C. Angelini, J. Schaefer, S. Sacconi, G. Siciliano, J. J. Vilchez and D. Hilton?JonesChapter 20 Diagnosis and Management of Neuromyelitis Optica (pages 287–307): J. Sellner, M. Boggild, M. Clanet, R. Q. Hintzen, Z. Illes, X. Montalban, R. A. Du Pasquier, C. H. Polman, P. Soelberg Sorensen and B. HemmerChapter 21 Screening for Tumours in Paraneoplastic Syndromes (pages 309–320): M. J. Titulaer, R. Soffietti, J. Dalmau, N. E. Gilhus, B. Giometto, F. Graus, W. Grisold, J. Honnorat, P. A. E. Sillevis Smitt, R. Tanasescu, C. A. Vedeler, R. Voltz and J. J. G. M. VerschuurenChapter 22 Treatment of Miscellaneous Idiopathic Headache Disorders (pages 321–335): S. Evers, P. Goadsby, R. Jensen, A. May, J. Pascual and G. SixtChapter 23 Treatment of Medication Overuse Headache (pages 337–344): S. Evers and R. Jensen Clinical Features Of Hyperkinetic Disorders / Alberto Albanese And Joseph Jankovic -- Pathophysiology And Molecular Pathology Of Dystonia And Tics / Marie Vidailhet, Michael Schupbach, And David Grabli -- Pathophysiology And Molecular Pathology Of Tremor, Myoclonus, And Chorea / Johannes D. Speelman, Elisabeth M. Foncke, Anne-fleur Van Rootselaar And Marina A. Tijssen -- Overview Of The Medical Treatments Of Hyperkinetic Movement Disorders / William Ondo -- Movement Disorders : Overview Of Surgical Treatment Possibilities In Hyperkinetic Disorders / Vinata Vedam-mai, Oscar Bernal, And Michael S. Okun -- Essential Tremor / Julián Benito-león And Elan D. Louis -- Tremor Disorders / Claustre Pont-sunyer, Eduardo Tolosa, And Judith Navarro-otano -- Primary Dystonias / Antonio A. Elia And Alberto Albanese -- Secondary Dystonia : Clinical Clues And Syndromic Associations / Susanne A. Schneider -- Huntington Disease And Other Genetic Choreas / Ainhi Ha And Joseph Jankovic -- Acquired Choreas / Ruth H. Walker -- Tics And Tourette Syndrome / Joseph Jankovic -- Secondary Tics / Francisco Cardoso -- Inherited Myoclonus Syndromes / Emmanuel Roze And Emmanuelle Apartis -- Segmental Myoclonus / John Nathaniel Caviness -- Other Jerks And Startles / Codrin Lungu And Mark Hallett -- Clinical And Pathophysiological Features Of Cerebellar Dysfunction / Giuliana Grimaldi And Mario Manto -- Inherted And Sporadic Ataxias / Hélio A. G. Teive, Renato P. Munhoz, And Tetsuo Ashizawa -- Dyskinesias In Parkinsonian Syndromes / S. Elizabeth Zauber And Christopher G. Goetz -- Restless Legs Syndrome / Pamela Hamilton-stubbs And Arthur S. Walters -- Tardive Dyskinesias / Gonzalo J. Revuelta ... [et Al.] -- Stereotypies And Other Developmental Hyperkinesias / Jayasri Srinivasan And Jonathan W. Mink -- Paroxysmal Dyskinesias / Miryam Carecchio, João Massano And Kailash P. Bhatia -- Psychogenic Movement Disorders / Stanley Fahn. Edited By Alberto Albanese, Joseph Jankovic. A Companion Site With All The Videos Cited In This Book Can Be Found At Www.wiley.com/go/albanese/movement--p. Facing T.p. Includes Bibliographical References And Index. Table of Contents: Clinical features of hyperkinetic disorders / Alberto Albanese and Joseph Jankovic Pathophysiology and molecular pathology of dystonia and tics / Marie Vidailhet, Michael Schupbach, and David Grabli Pathophysiology and molecular pathology of tremor, myoclonus, and chorea / Johannes D. Speelman, Elisabeth M. Foncke, Anne-Fleur van Rootselaar and Marina A. Tijssen Overview of the medical treatments of hyperkinetic movement disorders / William Ondo Movement disorders : overview of surgical treatment possibilities in hyperkinetic disorders / Vinata Vedam-Mai, Oscar Bernal, and Michael S. Okun Essential tremor / Julian Benito-Leon and Elan D. Louis Tremor disorders / Claustre Pont-Sunyer, Eduardo Tolosa, and Judith Navarro-Otano Primary dystonias / Antonio A. Elia and Alberto Albanese Secondary dystonia : clinical clues and syndromic associations / Susanne A. Schneider Huntington disease and other genetic choreas / Ainhi Ha and Joseph Jankovic Acquired choreas / Ruth H. Walker Tics and Tourette syndrome / Joseph Jankovic Secondary tics / Francisco Cardoso Inherited myoclonus syndromes / Emmanuel Roze and Emmanuelle Apartis Segmental myoclonus / John Nathaniel Caviness Other jerks and startles / Codrin Lungu and Mark Hallett Clinical and pathophysiological features of cerebellar dysfunction / Giuliana Grimaldi and Mario Manto Inherted and sporadic ataxias / Helio A. G. Teive, Renato P. Munhoz, and Tetsuo Ashizawa Dyskinesias in Parkinsonian syndromes / S. Elizabeth Zauber and Christopher G. Goetz Restless legs syndrome / Pamela Hamilton-Stubbs and Arthur S. Walters Tardive dyskinesias / Gonzalo J. Revuelta ... [et al.] Stereotypies and other developmental hyperkinesias / Jayasri Srinivasan and Jonathan W. Mink Paroxysmal dyskinesias / Miryam Carecchio, Joao Massano and Kailash P. Bhatia Psychogenic movement disorders / Stanley Fahn Hyperkinetic movement disorders comprise a range of diseases characterized by unwanted and uncontrollable, or poorly controllable, involuntary movements. The phenomenology of these disorders is quite variable encompassing chorea, tremor, dystonia, myoclonus, tics, other dyskinesias, jerks and shakes. Discerning the underlying condition can be very difficult given the range and variability of symptoms. But recognizing the phenomenology and understanding the pathophysiology are essential to ensure appropriate treatment. Hyperkinetic Movement Disorders provides a clinical pathway for effective diagnosis and management of these disorders. The stellar international cast of authors distils the evidence so you can apply it into your practice. The judicious use of diagnostic criteria algorithms rating scales management guidelines Provides a robust framework for clear patient management. Throughout the text, QR codes• provide smartphone access to case-study videos of hyperkinetic symptoms. Purchase includes an enhanced Wiley Desktop Edition.• This is an interactive digital version featuring: all text and images in fully searchable form integrated videos of presentations View a sample video: www.wiley.com/go/albanese highlighting and note taking facilities book marking linking to additional references Hyperkinetic Movement Disorders provides you with the essential visual and practical tools you need to effectively diagnose and treat your patients. •Full instructions for using QR codes and for downloading your digital Wiley DeskTop Edition are inside the book. Effective stroke therapy can be improved through real-time monitoring of the neurological and cardiovascular responses to treatment. This requires crucial knowledge on behalf of both the sonographer and stroke physician to make the best decisions for the patient so as to minimize the damage caused by the original stroke and the risk of further stroke. Cerebrovascular Ultrasound in Stroke Prevention and Treatment, Second Edition, takes a practical approach to the examination of patients, the interpretation of ultrasound studies and the application of cerebrovascular ultrasound in the development of management and treatment studies, assisting neurologists, radiologists, and ultrasonographers in stroke therapy. Neurological diseases present challenging management issues. Patients vary widely in the symptoms that need to be controlled and in their response to different treatments. Evidence continuously accumulates on the effectiveness of different approaches; new treatments regularly enter the market. This important resource offers a compendium of peer-reviewed guidelines for the treatment and management of neurological disease. Published in association with the European Federation of Neurological Societies, the information is based on evidence and/or the consensus of a range of experts from across Europe that has been published in the European Journal of Neurology. "Cerebrovascular Ultrasound in Stroke Prevention and Treatment, Second Edition, assists neurologists, radiologists, and ultrasonographers in stroke therapy by providing practical approaches to the examination of patients, the interpretation of ultrasound studies, and the application of cerebrovascular ultrasound in the development of management and treatment studies. Full-color images and case studies add to the book's appeal."--Provided by publisher Parkinson's Disease has traditionally been seen as a movement disorder, and diagnosed by the development of tremor. However, we are beginning to understand that the disease manifests itself in many ways, and that earlier diagnosis might be possible through non-tremor symptoms. This textbook aims to tell the full story of non-motor and non-dopaminergic features of Parkinson's Disease.