Estrogens And Antiestrogens Ii: Pharmacology And Clinical Application Of Estrogens And Antiestrogen (handbook Of Experimental Pharmacology)

For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and anti estrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of pUblications from which new principles of preventive and therapeutic appli­ cations of estrogens and anti estrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro­ gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu­ ously hallmark results in reproductive endocrinology worldwide. Front Matter....Pages I-XXXIII Front Matter....Pages 1-1 In Vitro and In Vivo Models to Characterise Estrogens and Antiestrogens....Pages 3-94 Estrogen Receptor β in the Pharmacology of Estrogens and Antiestrogens....Pages 95-104 Interrelationship of Estrogens with other Hormones or Endocrine Systems....Pages 105-111 Mammary Gland....Pages 113-128 Cardiovascular System....Pages 129-140 Bone....Pages 141-149 Central Nervous System....Pages 151-162 Liver Inclusive Protein, Lipid and Carbohydrate Metabolism....Pages 163-178 Pharmacology of Antiestrogens....Pages 179-194 Oncology....Pages 195-203 Hormonal Resistance in Breast Cancer....Pages 205-221 Pharmacology of Inhibitors of Estrogen Biosynthesis....Pages 223-230 Pharmacology of Inhibition of Estrogen-Metabolizing Enzymes....Pages 231-245 Pharmacology of Different Administration Routes - Oral vs Transdermal....Pages 247-257 Front Matter....Pages 259-259 Pharmacokinetics of Exogenous Natural and Synthetic Estrogens and Antiestrogens....Pages 261-322 Toxicology of Estrogens and Antiestrogens....Pages 323-351 Estrogens and Sexually Transmitted Diseases....Pages 353-360 Front Matter....Pages 361-361 Hormonal Contraception....Pages 363-407 Hormone Replacement Including Osteoporosis....Pages 409-422 Gynaecological Disorders....Pages 423-430 Front Matter....Pages 361-361 Oncology....Pages 431-445 Cardiology....Pages 447-460 Urogenital Ageing and Dermatology....Pages 461-471 Geriatric Neurology and Psychiatry....Pages 473-503 Estrogens and Antiestrogens in the Male....Pages 505-571 Front Matter....Pages 573-573 Comparative Aspects of Estrogen Biosynthesis and Metabolism and the Endocrinological Consequences in Different Animal Species....Pages 575-602 Therapeutic Use of Estrogens in Veterinary Medicine....Pages 603-610 Environmental Estrogen....Pages 613-663 Back Matter....Pages 665-683 These volumes cover all relevant aspects of recent research in estrogens and antiestrogens from chemistry, physiology, pharmacology to clinical applications. Particular emphasis is devoted to new developments in the area of estrogen receptors including estrogen receptor € and the mode of action of novel partial estrogen agonists/antagonists. Further topics address the importance of estrogens and anti- estrogens in fertility, aging, cancer, animal husbandry and environment. Part II extends the information from Part I addressing the broad variety of pharmacological activities, their kinetics and toxicology. Particular emphasis is placed on the potential of these compounds in an impressive number of clincial indications. The chapters have been written by internationally renowned experts in their fields. Due to their broad scope, these volumes will be indispensable reference books in any library Covers all relevant aspects of late-20th century research in estrogens and antiestrogens from chemistry and pharmacology to clinical applications. Emphasis is placed on developments in the area of estrogen receptors, including the mode of action of novel partial estrogen agonists/antagonists.