Estrogen Effects on Traumatic Brain Injury : Mechanisms of Neuroprotection and Repair

This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain Injury is of great importance to teachers, researchers, and clinicians interested in the role that estrogens play following traumatic brain injury. Written to provide a foundational view of estrogens as neuroprotectors in TBI, appropriate for both researchers and advanced students Data Analysis boxes in each chapter help with data interpretation and offer guidelines on how best to understand results. A multidisciplinary approach to the methods, issues, empirical findings in the field of estrogen mediated neuroprotection. Detailed focus on how studies relate and build upon each other and the ways different methods of analysis inform each other. Written to provide clinicians with new and developing treatment options for patients in their field. Content: Front-matter, Pages i,iii Copyright, Page iv About the Editor, Page ix List of Contributors, Pages xi-xii, Marco Ávila-Rodriguez, Taura L. Barr, George E. Barreto, Suzanne R. Burstein, Francisco Capani, Laura L. Carruth, Rocío Castilla, Pascal Coumailleau, Nicolas Diotel, Kelli A. Duncan, Luis Miguel García-Segura, Janneth Gonzalez, John P. Hayden, Olivier Kah, Rodolfo Kolliker, Ana Belen Lopez-Rodriguez, Carissa J. Mehos, Alyssa L. Pedersen, Elisabeth Pellegrini, Ashley B. Petrone, Miranda N. Reed, et al. About the Contributors, Pages xiii-xx Introduction, Pages xxi-xxii Chapter 1 - Historical Antecedents, Pages 1-10, John P. Hayden Chapter 2 - Estrogen Actions in the Brain, Pages 11-28, Laura L. Carruth, Mahin Shahbazi Chapter 3 - Induction of Estrogen Response Following Injury, Pages 29-41, Suzanne R. Burstein, Kelli A. Duncan Chapter 4 - Astrocytic Aromatization and Injury, Pages 43-49, Colin J. Saldanha, Carissa J. Mehos, Alyssa L. Pedersen, William A. Wiggins Chapter 5 - Aromatase and Estrogens: Involvement in Constitutive and Regenerative Neurogenesis in Adult Zebrafish, Pages 51-71, Elisabeth Pellegrini, Pascal Coumailleau, Olivier Kah, Nicolas Diotel Chapter 6 - Neuroprotection by Exogenous Estrogenic Compounds Following Traumatic Brain Injury, Pages 73-90, Ana Belen Lopez-Rodriguez, Marco Ávila-Rodriguez, Nelson E. Vega-Vela, Francisco Capani, Janneth Gonzalez, Luis Miguel García-Segura, George E. Barreto Chapter 7 - Neuroprotective Effects of Estrogen Following Neural Injury, Pages 91-111, Ashley B. Petrone, Carolyn C. Rudy, Taura L. Barr, James W. Simpkins, Miranda N. Reed Chapter 8 - Neuroprotection with Estradiol in Experimental Perinatal Asphyxia: A New Approach, Pages 113-124, George Barreto, Ezequiel Saraceno, Janneth Gonzalez, Rodolfo Kolliker, Rocío Castilla, Francisco Capani Chapter 9 - Cerebrovascular Stroke: Sex Differences and the Impact of Estrogens, Pages 125-141, Farida Sohrabji Chapter 10 - Concluding Statements and Current Challenges, Pages 143-144 Index, Pages 145-149

This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain Injury is of great importance to teachers, researchers, and clinicians interested in the role that estrogens play following traumatic brain injury.

• Written to provide a foundational view of estrogens as neuroprotectors in TBI, appropriate for both researchers and advanced students
• Data Analysis boxes in each chapter help with data interpretation and offer guidelines on how best to understand results.
• A multidisciplinary approach to the methods, issues, empirical findings in the field of estrogen mediated neuroprotection.
• Detailed focus on how studies relate and build upon each other and the ways different methods of analysis inform each other.
• Written to provide clinicians with new and developing treatment options for patients in their field.

This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, __Estrogen Effects on Traumatic Brain Injury__ is of great importance to teachers, researchers, and clinicians interested in the role that estrogens play following traumatic brain injury.