Esmo Handbooks: Esmo Handbook On Principles Of Translational Research (european Society For Medical Oncology Handbooks) (volume 1)

This source presents the principles of cell biology, cellular pathways, and their implications for drug development in oncology. Using state-of-the-art and evidence-based literature references and reviews, with illustrations as necessary, the authors present an overview that is both reliable and easily understood. Cover......Page 1 ESMO Handbook of Principles of Translational Research......Page 2 Contents......Page 6 Foreword......Page 10 1 Principles of normal cell biology......Page 12 2 Principles of immunology: an overview of basic immunology......Page 34 3 Principles of tumor biology......Page 42 4 Fundamentals of tumor immunology......Page 50 5 Self-sufficiency......Page 58 6 Limitless replicative potential......Page 66 7 Regulation of apoptosis......Page 78 8 Angiogenesis......Page 92 9 Cancer cells and tumor-associated host cells: therapeutic implications......Page 100 10 New drug development......Page 108 11 Inhibition of receptor tyrosine kinases......Page 116 12 Monoclonal antibodies......Page 126 13 Gene therapy......Page 132 14 Cancer vaccines......Page 140 15 Combination treatment......Page 146 16 Safety of targeted therapies......Page 152 17 Functional immunology and biomarkers......Page 168 18 Assessment of protein profiles (proteomics) as biomarkers......Page 178 Index......Page 184 Back Cover......Page 192 Using state-of-the-art and evidence-based literature references and reviews, the authors present an overview of translational research that is both reliable and easily understood. The book begins with principles of normal cell biology and normal immunology. It examines tumor biology and basic tumor immunology. It then discusses limitless replicativ