Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology (Milestones in Drug Therapy)

A comprehensive one-source guide to the most current information on red blood cell formation and the action of recombinant human erythropoietins. Topics covered include: erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators. This softcover volume is an unchanged second printing of the hardcover edition published in 2003. Covers Much Information On Erythropoiesis And Red Blood Cell Production, Its Regulation, And Areas Of Continued Research. Discusses Topics In The Fields Of Erythropoiesis, Recombinant Protein Discovery And Production, And Treatment Of Patients With Anemia. I. Background And Basic Science -- Erythropoiesis : An Overview / Lyonel G. Israels And Esther D. Israels -- Studies Of Erythropoiesis And The Discovery And Cloning Of Recombinant Human Erythropoietin / Maryann Foote -- Structural Basis For The Signal Transduction Of Erythropoietin / Timothy Osslund And Rashid Syed -- Molecular Biology Of The Erythropoietin Receptor In Hematopoietic And Non-hematopoietic Tissues / Christof Dame -- Erythropoietin Receptor Signaling Processes / Saghi Ghaffari [and Others] -- Clinical Pharmacokinetic Properties Of Rhuepo : A Review / Anne C. Heatherington -- Biology Of Erythropoietin / Graham Molineux -- Commercial Production Of Recombinant Erythropoietins / Alice S. Chuck [and Others] -- Ii. Clinical Use Of Recombinant Erythropoietins -- Use Of Recombinant Erythropoietins In The Setting Of Renal Disease / Lain C. Macdougall -- Erythropoietic Therapy In The Practice Of Oncology / John Glaspy -- Use Of Recombinant Erythropoietins For The Treatment Of Anemia Of Chronic Disease / Robert T Means, Jr. -- Use Of Erythropoietins In The Surgical Setting / Fred D. Cushner -- Abuse Of Recombinant Erythropoietins By Athletes / Don H. Catlin, Caroline K. Hatton, And Francoise Lasne -- Antibodies To Endogenous And Recombinant Erythropoietin / Patrick Mayeux And Nicole Casadevall -- New Molecules And Formulations Of Recombinant Human Erythropoietin / Steven G. Elliott. Edited By G. Molineux, M.a. Foote, And S.g. Elliott. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Although much has been learned and published, new, exciting data are becoming ava- able on almost a daily basis. Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology compiles both pertinent historical and very recent research on this molecule and its clinical utility. The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified, cloned, and expressed, the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems "This volume is a one-source guide to the most current information about red blood cell formation and the action of recombinant human erythropoietins. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia are covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed." "It is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators."--Jacket