Epstein Barr Virus Volume 1: One Herpes Virus: Many Diseases (Current Topics in Microbiology and Immunology Book 390)

Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt’s lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future. Part I, History -- Why And How Epstein-barr Virus Was Discovered 50 Years Ago / Anthony Epstein -- Tumor Associations Of Ebv, Historical Perspectives / George Klein -- Ebv-specific Immune Response: Early Research And Personal Reminiscences / D.j. Moss And V.p. Lutzky -- Part Ii, Virus Genetics And Epigenetics -- Epstein-barr Virus Strain Variation / Paul J. Farrell -- Chromatin Structure Of Epstein-barr Virus Latent Episomes / Paul M. Leiberman -- The Epigenetic Life Cycle Of Epstein-barr Virus / Wolfgang Hammerschmidt -- Epstein-barr Virus: From The Detection Of Sequence Polymorphisms To The Recognition Of Viral Types / Regina Feederle, Olaf Klinke, Anton Kutikhin, Remy Poirey, Ming-han Tsai And Henri-jacques Delecluse -- Part Iii, Viral Infection And Associated Diseases -- Ebv Persistence: Introducing The Virus / David A. Thorley-lawson -- Infectious Mononucleosis / Samantha K. Dunmire, Kristin A. Hogquist And Henry H. Balfour -- Primary Immunodeficiencies Associated With Ebv Disease / Jeffrey I. Cohen -- Burkitt's Lymphoma / Rosemary Rochford And Ann M. Moorman -- Contribution Of The Epstein-barr Virus To The Pathogenesis Of Hodgkin Lymphoma / Paul Murray And Andrew Bell -- The Role Of Ebv In The Pathogenesis Of Diffuse Large B Cell Lymphoma / Jane A. Healy And Sandeep S. Dave -- Nasopharyngeal Carcinoma: An Evolving Role For The Epstein-barr Virus / Nancy Raab-traub -- Ebv And Autoimmunity / Alberto Ascherio And Kassandra L. Munger. Christian Münz, Editor. Includes Bibliographical Reference And Index. Front Matter....Pages i-viii Front Matter....Pages 1-1 Why and How Epstein-Barr Virus Was Discovered 50 Years Ago....Pages 3-15 Tumor Associations of EBV—Historical Perspectives....Pages 17-22 EBV-Specific Immune Response: Early Research and Personal Reminiscences....Pages 23-42 Front Matter....Pages 43-43 Epstein–Barr Virus Strain Variation....Pages 45-69 Chromatin Structure of Epstein–Barr Virus Latent Episomes....Pages 71-102 The Epigenetic Life Cycle of Epstein–Barr Virus....Pages 103-117 Epstein–Barr Virus: From the Detection of Sequence Polymorphisms to the Recognition of Viral Types....Pages 119-148 Front Matter....Pages 149-149 EBV Persistence—Introducing the Virus....Pages 151-209 Infectious Mononucleosis....Pages 211-240 Primary Immunodeficiencies Associated with EBV Disease....Pages 241-265 Burkitt’s Lymphoma....Pages 267-285 Contribution of the Epstein-Barr Virus to the Pathogenesis of Hodgkin Lymphoma....Pages 287-313 The Role of EBV in the Pathogenesis of Diffuse Large B Cell Lymphoma....Pages 315-337 Nasopharyngeal Carcinoma: An Evolving Role for the Epstein–Barr Virus ....Pages 339-363 EBV and Autoimmunity....Pages 365-385 Back Matter....Pages 387-391