معرفی کتاب «Epstein-Barr virus and human disease, 1990 : [based on the fourth International symposium on Epstein-Barr virus and associated malignant diseases, held in Hua-lien, Taiwan, Sept. 23-28, 1990» نوشتهٔ Nancy Raab-Traub, Hiroshi Sato, Kevin Gilligan, Pathmanathan Rajadurai, Toru Takimoto (auth.), D. V. Ablashi, A. T. Huang, J. S. Pagano, G. R. Pearson, C. S. Yang, Kristinë L. Ablashi (eds.)، منتشرشده توسط نشر Humana Press : Imprint : Humana Press در سال 1991. این کتاب در فرمت pdf، زبان انگلیسی ارائه شده است.
The Epstein-Barr virus (EBV), isolated in 1966, continues to draw worldwide attention as an important human pathogen. Its impor tance is largely related to the continuing accumulation of evidence that implicates EBV as an etiological factor for certain types of human cancer. More recent investigations on this virus have focused on the identity of the viral genes responsible for the different disease mani festations observed following viral infection. It is hoped that by thorough investigation of this virus, clues to how cancer develops from a normal cell will surface. In addition, many of the gene products are now being exploited for the development of new and more sensitive tests for the diagnosis and clinical management of individu als with EBV -associated diseases. Thus, studies on this virus continue to provide new information of importance to our understanding of the malignant process. In an effort to attract both basic and clinical scientists to the same meeting for purposes of scientific exchange and fostering a closer interaction between these individuals, a series of international symposia was initiated in 1984. The first meeting was held in Loutraki, Greece, and was attended by approximately 100 participants. The second international symposium was held in St. Petersburg, Florida, in 1986, and was attended by approximately twice as many partici pants as attended the Loutraki meeting. Front Matter....Pages i-xliv Front Matter....Pages 1-1 Replication of the Epstein-Barr Virus in Lymphoid and Epithelial Cells....Pages 3-12 The Productive Cycle Defect in Raji EBV is not Solely Due to Absence of the Balf2 Gene....Pages 13-18 Interference of EBNA-1 Binding to Ori-P by Cellular Proteins (ANTI-EBNA1) ....Pages 19-25 How Zebra, A Weak Transactivator, Exerts Strong Biologic Effects....Pages 27-42 EBNA-2 Transactivation of CD23....Pages 43-46 EBNA-2 Transactivation of LMP1....Pages 47-51 A New Lymphoid-Specific Epstein-Barr Virus Enhancer is Transactivated by EBNA-2....Pages 53-57 Transcriptional Regulation of an Epstein-Barr Virus Nuclear Antigen Gene Promoter....Pages 59-63 EBNA-2 Influences Promoter Function in Burkitt Lymphoma Cells....Pages 65-67 Functional Characterization of Epstein-Barr Virus DNA Polymerase by in Vitro Transcription-Translation of Cloned Genes....Pages 69-73 Epstein-Barr Virus Recombinants: Use of Positive Selection Markers to Rescue Mutants in EBV Negative B Lymphoma Cells....Pages 75-79 Characterization of EBV DNase Related Transcripts....Pages 81-85 The Pst I-Repeats of the Epstein-Barr Virus Encode a Protein with a Molecular Weight Between 115,000 and 140,000....Pages 87-91 The EBV BRLF1 Protein Has Sequence And Functional Similarity With The C-myb Oncogene....Pages 93-97 Heterodimers of the Zebra and Fos Basic Domains Bind DNA with the Specificity of Zebra....Pages 99-103 Relationship of the EBV Lytic Activator Zta to the bZIP Family of Cellular Transactivators....Pages 105-109 Trans-regulation of the Early MS Gene of EBV and Its Dependence on the Host Cell....Pages 111-115 Induction and Regulation of Expression of the Epsteinbarr Virus DNA Polymerase Gene....Pages 117-121 Recombinant EBV Antigens and Their Diagnostic Value....Pages 123-125 Epstein-Barr Virus Associated Histio-Lymphoproliferative Syndromes in Two European Families....Pages 127-130 Front Matter....Pages 131-131 Role of Cytokines in EBV-Infected Cell Growth....Pages 133-142 Epstein-Barr Virus Variants at Mucosal Surfaces....Pages 143-146 Epstein-Barr Virus Infection and Monokine Synthesis....Pages 147-151 Transcription from Bam HI A in NPC....Pages 153-156 Characterisation of the Novel “18.8” Family of Transcripts from NPC Tumours....Pages 157-161 EBER1 Small Nuclear RNA in Malignancy: A Morphologically Distinctive Target for Detection of EBV in Formalin-Fixed Paraffin-Embedded Specimens....Pages 163-167 Tumorigenicity and Organization of the Terminal Region of the Epstein-Barr Virus (EBV) Genome in LCLs Derived from Carcinogen-Treated Lymphocytes....Pages 169-173 Expression of EBNA2 and an EBNA5 Protein from Alternatively Spliced mRNA’s....Pages 175-180 Front Matter....Pages 181-181 EBV Humoral Immunology: 1966–1990....Pages 183-189 The Role of EBNA Proteins as a Target for EBV-Specific T Cell Lysis....Pages 191-200 Role of the Epstein-Barr Virus (EBV) Glycoprotein GP350 as a Target Antigen for EBV-Specific Cellular Killing....Pages 201-206 Mapping of B and T Cell Epitopes on the Epstein-Barr Virus Receptor Ligand Gp340: A Candidate Subunit Vaccine....Pages 207-211 Identification of T Helper Cell Epitopes On gp340....Pages 213-217 Reactivity of EBV Type A-Specific Cytotoxic T-Cells....Pages 219-223 DNA Sequence Variation in EBV-Encoded T-Cell Epitopes....Pages 225-229 Recombinant Adenoviruses Which Express the EBV Major Membrane Antigen GP340/220 Induce Persistent EBV-Neutralizing Antibodies in Rabbits....Pages 231-236 Inhibition of the EBV Lytic Cycle by Sequence Specific Antisense Oligonucleotides....Pages 237-240 Front Matter....Pages 241-241 Advances in the Understanding of EBV Associated Lymphoproliferative Disorders....Pages 243-272 The Association of Epstein-Barr Virus with Lymphoproliferative Disorders: A Re-evaluation Using the Polymerase Chain Reaction....Pages 273-276 Absence of EBV in Reed-Sternberg Cells in Many Cases of Hodgkin’s Disease....Pages 277-281 Front Matter....Pages 241-241 EBV and Granular Lymphocytes Proliferation....Pages 283-287 EBV Transmission and Expression among Patients with PTLD....Pages 289-293 SCID Mouse Model of Virus-Induced Lymphomagenesis of Immunodeficient Humans....Pages 295-300 Patients with Psoriasis Have High Serum Reactivity with EBNA-2B....Pages 301-304 EBV Activation By Anti-IgG-Triggered, Second Messenger Pathways....Pages 305-309 Front Matter....Pages 311-311 Nasopharyngeal Carcinoma: 1990....Pages 313-330 In Situ Analysis of Epstein-Barr Viral Expression in Nasopharyngeal Carcinoma....Pages 331-338 Interaction of EBV Genes with Human Epithelial Cells....Pages 339-345 Studies on the Terminal Protein 1 (TP1) of the Epstein-Barr Virus and the ANTI-TP Immune Response in Humans....Pages 347-351 Diagnosis of Nasopharyngeal Carcinoma Using the Epstein-Barr Virus Coded Alkaline Dnase, Membrane Antigen and Thymidine Kinase....Pages 353-356 Detection of Anti-Epstein Barr Virus Transactivator (Zebra) Antibodies in Sera From Patients With Nasopharyngeal Carcinoma....Pages 357-363 EBV PP58 and DNase Expressed in the Baculovirus System May Improve the Diagnosis of NPC....Pages 365-369 Efficacy of Exfoliative Cytology in Diagnosis of Nasopharyngeal Carcinoma....Pages 371-375 Neoadjuvant Approach with Bleomycin, Epirubicin and Cisplatin in the Treatment of Locally Advanced UCNT....Pages 377-381 Front Matter....Pages 383-383 Pathogenesis of Nasopharyngeal Carcinoma....Pages 385-390 EBV Genome Organization in Lymphoblastoid Cell Lines Established Following Enhancement With Aflatoxin B1 and Relevance to Nasopharyngeal Carcinoma....Pages 391-405 Preliminary Results of HLA Class I and Class II Antigens in Chinese with Nasopharyngeal Carcinoma ◊ ....Pages 407-411 Radiation Therapy of Nasopharyngeal Cancer in Taiwan University Hospital 1958–1989....Pages 413-416 Chemotherapy in Undifferentiated Type Nasopharyngeal Carcinoma (UCNT)....Pages 417-420 Neoadjuvant Chemotherapy Plus Radiotherapy Versus Radiotherapy Alone in Nasopharyngeal Cancer....Pages 421-425 Front Matter....Pages 383-383 The Role of Surgery in the Management of Recurrent Primary Nasopharyngeal Carcinoma....Pages 427-430 Randomized Controlled Studies on Immunotherapy of Nasopharyngeal Carcinoma with OK-432....Pages 431-434 A Preliminary Study on the Immunogenicity in Rabbits and in Human Volunteers: Recombinant Vaccinia Virus Expressing Epstein-Barr Virus Membrane Antigen....Pages 435-439 Back Matter....Pages 441-455
The Epstein-Barr virus continues to be the focus of much worldwide attention as a significant pathogen for a variety of human diseases, including certain types of cancer.
In the new Epstein-Barr Virus and Human Disease • 1990, special attention is given to investigations of the various genes responsible for the different manifestations caused by viral infection, as well as to promising new research that may yield clues to how cancer develops from a normal cell.
In the present volume, renowned experts from many countries offer up-to-date information and insights into the fast-paced field of EBV research, including:
• nasopharyngeal carcinoma • lymphoproliferative diseases • molecular aspects of EBV • molecular genetics of EBV • pathobiology of EBV-related diseases • immunology of EBV-related disorders • future trends in EBV research.
Epstein-Barr Virus and Human Disease • 1990 is an essential resource for everyone concerned with either the experimental or clinical aspects of EBV virology, immunology, pathology, molecular biology, oncology, and related fields.
Booknews
Papers from the Fourth International Symposium on Epstein-Barr Virus and Associated Malignant Diseases, held in Hualien, Taiwan, September 1990, give special attention to the various genes involved in viral infection, as well as to new research on how cancer develops from a normal cell. Among the topics: nasopharyngeal carcinoma, lymphoproliferative diseases, molecular aspects of EBV, immunology of EBV-related disorders, future trends. Annotation c. Book News, Inc., Portland, OR (booknews.com)
The Epstein-Barr virus continues to be the focus of much worldwide attention as a significant pathogen for a variety of human diseases, including certain types of cancer.
In the new Epstein-Barr Virus and Human Disease ⢠1990, special attention is given to investigations of the various genes responsible for the different manifestations caused by viral infection, as well as to promising new research that may yield clues to how cancer develops from a normal cell.
In the present volume, renowned experts from many countries offer up-to-date information and insights into the fast-paced field of EBV research, including:
⢠nasopharyngeal carcinoma ⢠lymphoproliferative diseases ⢠molecular aspects of EBV ⢠molecular genetics of EBV ⢠pathobiology of EBV-related diseases ⢠immunology of EBV-related disorders ⢠future trends in EBV research.
Epstein-Barr Virus and Human Disease ⢠1990 is an essential resource for everyone concerned with either the experimental or clinical aspects of EBV virology, immunology, pathology, molecular biology, oncology, and related fields.