Epstein-Barr Virus and Human Cancer (Current Topics in Microbiology and Immunology, 258)

In this book, outstanding researchers from the US and Japan review recent progress in Epstein-Barr virus research. Most people carry EBV in memory B-cells in a latent stage. Many malignancies such as T/NK cell lymphoma, AIDS-associated B-cell lymphoma, gastric carcinoma and Hodgkin's disease have been causally linked to EBV. The development of molecular biology technique has allowed us to study the roles of individual EBV genes that act in the maintenance and disruption of EBV latency. Front Matter....Pages I-IX Front Matter....Pages 1-1 EBV’s Plasmid Replicon: An Enigma in cis and trans ....Pages 3-11 Replication Licensing of the EBV oriP Minichromosome....Pages 13-33 Epstein-Barr Virus Nuclear Protein 2-Induced Activation of the EBV-Replicative Cycle in Akata Cells: Analysis by Tetracycline-Regulated Expression....Pages 35-50 Two Epstein-Barr Virus Glycoprotein Complexes....Pages 51-64 EBV Replication Enzymes....Pages 65-87 Front Matter....Pages 89-89 Pathology and Molecular Pathology of Epstein-Barr Virus-Associated Gastric Carcinoma....Pages 91-102 EBV and Malignant Lymphoma with Special Emphasis on Pyothorax-Associated Lymphoma....Pages 103-120 AIDS Lymphoma: Its Virological Aspects....Pages 121-138 Front Matter....Pages 139-139 Role of Epstein-Barr Virus in Burkitt’s Lymphoma....Pages 141-151 EBV Regulates c-MYC, Apoptosis, and Tumorigenicity in Burkitt’s Lymphoma....Pages 153-160 Epstein-Barr Virus Infection of Human Epithelial Cells....Pages 161-184 Characterization of EBV-Infected Epithelial Cell Lines from Gastric Cancer-Bearing Tissues....Pages 185-198 Front Matter....Pages 199-199 A New Animal Model for Epstein-Barr Virus Pathogenesis....Pages 201-219 Adoptive Immunotherapy of EBV-Associated Malignancies with EBV-Specific Cytotoxic T-Cell Lines....Pages 221-229 Back Matter....Pages 231-236