Epigenetics in Cardiac Disease (Cardiac and Vascular Biology Book 1)

This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics. Front Matter....Pages i-viii Epigenetics: Chromatin Organization and Function....Pages 1-35 Epigenome Dynamics and Reader Proteins in Cardiomyocyte Development and Heart Failure....Pages 37-51 Epigenetic Regulations in Cardiac Development....Pages 53-73 DNA Methylation in Heart Failure....Pages 75-102 Chromatin Remodeling in Heart Failure....Pages 103-124 Histone Methylation in Heart Development and Cardiovascular Disease....Pages 125-146 The Lysine Acetyltransferases in Cardiovascular Disease....Pages 147-190 HDAC Signaling Networks in Heart Failure....Pages 191-208 Epigenetic and Nongenomic Roles for Histone Deacetylases in Heart Failure....Pages 209-229 Cardiac Autophagy and Its Regulation by Reversible Protein Acetylation....Pages 231-262 Sirtuins as Regulators of Cardiac Hypertrophy and Heart Failure....Pages 263-282 BET Bromodomains and P-TEFb in Cardiac Transcription and Heart Failure Pathogenesis....Pages 283-296 Long Noncoding RNAs in Heart Disease....Pages 297-316