Epigenetics, Environment, and Genes

Epigenetics refers to DNA and chromatin modifications that play an important role in the regulation of various genomic functions. This important book reviews human and cellular data that underline paradoxical findings with respect to the contribution of heredity and environment to phenotype. The contributors then reinterpret these experiments that incorporate epigenetic factors. Topics include DNA methylation, histone modifications, chromatin modifications, the role of epigenetic modifications and environment on gene expression, and integrating genomic medicine into clinical practice. Pt. I. From genes to epigenomes. The epigenetic perspective / Albert H.C. Wong, Irving I. Gottesman, and Arturas Petronis Correlating CpG islands, motifs, and sequence variants / Leah Spontaneo and Nick Cercone pt. II. DNA methylation. Promoter hypermethylation / Davide Pellacani, Richard J. Packer, Fiona M. Frame, Emma E. Oldridge, Paul A. Berry, Marie-Christine Labarthe, Michael J. Stower, Matthew S. Simms, Anne T. Collins, and Norman J. Maitland Genome-wide mapping / Ryan K.C. Yuen, Ruby Jiang, Maria S. Peñaherrera, Deborah E. McFadden, and Wendy P. Robinson pt. III. Histone modifications. Gene silencing / Irina A. Maksakova, Preeti Goyal, Jörn Bullwinkel, Jeremy P. Brown, Misha Bilenky, Dixie L. Mager, Prim B. Singh, and Matthew C. Lorincz Histone (H1) phosphorylation / Anna Gréen, Bettina Sarg, Henrik Gréen, Anita Lönn, Herbert H. Lindner, and Ingemar Rundquist Post-translational modifications / Stephanie D. Byrum, Sean D. Taverna, and Alan J. Tackett pt. IV. Chromatin modifications. Chromatin signature / Brandon J. Thomas, Eric D. Rubio, Niklas Krumm, Pilib Ó. Broin, Karol Bomsztyk, Piri Welcsh, John M. Greally, Aaron A. Golden, and Anton Krumm Bivalent chromatin modification / Marco De Gobbi, David Garrick, Magnus Lynch, Douglas Vernimmen, Jim R. Hughes, Nicolas Goardon, Sidinh Luc, Karen M. Lower, Jacqueline A. Sloane-Stanley, Cristina Pina, Shamit Soneji, Raffaele Renella, Tariq Enver, Stephen Taylor, Sten Eirik W. Jacobsen, Paresh Vyas, Richard J. Gibbons, and Douglas R. Higgs pt. V. The role of environment during evolution. Adaptive divergence / Nora Khaldi and Denis C. Shields. This title includes a number of Open Access chapters.Epigenetics refers to DNA and chromatin modifications that play an important role in the regulation of various genomic functions. This important book reviews human and cellular data that underline paradoxical findings with respect to the contribution of heredity and environment to phenotype. The