Epigenetic Regulation Of Lymphocyte Development (current Topics In Microbiology And Immunology, Vol. 356)

Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression. Front Matter....Pages i-x Roles of Lineage-Determining Transcription Factors in Establishing Open Chromatin: Lessons From High-Throughput Studies....Pages 1-15 B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1....Pages 17-38 Epigenetic Features that Regulate IgH Locus Recombination and Expression....Pages 39-63 Local and Global Epigenetic Regulation of V(D)J Recombination....Pages 65-89 Genetic and Epigenetic Regulation of Tcrb Gene Assembly....Pages 91-116 T-Cell Identity and Epigenetic Memory....Pages 117-143 Encoding Stability Versus Flexibility: Lessons Learned From Examining Epigenetics in T Helper Cell Differentiation....Pages 145-164 The Epigenetic Landscape of Lineage Choice: Lessons From the Heritability of Cd4 and Cd8 Expression....Pages 165-188 Back Matter....Pages 189-191