Enzyme Handbook: Volume 15: First Supplement Part 1 Class 3: Hydrolases (Enzyme Handbook (See S794))

Today, as the large international genome sequence projects are gaining a great amount of public atte\_ntion and huge sequence data bases are created it be­ comes more and more obvious that we are very limited in our ability to access functional data for the gene products - the proteins, in particular for enzymes. Those data are inherently very difficult to collect, interpret and standardize as they are highly distributed among journals from different fields and are often sub­ ject to experimental conditions. Nevertheless a systematic collection is essential for our interpretation of the genome information and more so for possible appli­ cations of this knowledge in the fields of medicine, agriculture, etc .. Recent pro­ gress on enzyme immobilization, enzyme production, enzyme inhibition, coen­ zyme regeneration and enzyme engineering has opened up fascinating new fields for the potential application of enzymes in a large range of different areas. It is the functional profile of an enzyme that enables a biologist or physician to analyse a metabolic pathway and its disturbance; it is the substrate specificity of an enzyme which tells an analytical biochemist how to design an assay; it is the stability, specificity and efficiency of an enzyme which determines its usefulness in the biotechnical transformation of a molecule. And the sum of all these data will have to be considered when the deSigner of artificial biocatalysts has to choose the optimum prototype to start with. Front Matter....Pages I-XIII Acetoxybutynylbithiophene deacetylase....Pages 1-3 Acetylsalicylate deacetylase....Pages 5-8 Methylumbelliferyl-acetate deacetylase....Pages 9-12 2-Pyrone-4,6-dicarboxylate lactonase....Pages 13-15 N-Acetylgalactosaminoglycan deacetylase....Pages 17-20 Juvenile-hormone esterase....Pages 21-26 Bis(2-ethylhexyl)phthalate esterase....Pages 27-29 Protein-glutamate methylesterase....Pages 31-35 11-cis-Retinyl-palmitate hydrolase....Pages 37-39 all-trans-Retinyl-palmitate hydrolase....Pages 41-43 L-Rhamnono-1,4-lactonase....Pages 45-47 5-(3,4-Diacetoxybut-1-ynyl)-2,2’-bithiophene deacetylase....Pages 49-51 Fatty-acyl-ethyl-ester synthase....Pages 53-56 Xylono-1,4-lactonase....Pages 57-59 N-Acetylglucosaminylphosphatidylinositol deacetylase....Pages 61-63 Cetraxate benzylesterase....Pages 65-67 Ubiquitin thiolesterase....Pages 69-73 [Citrate-(pro-3S)-lyase] thiolesterase....Pages 75-77 (S)-Methylmalonyl-CoA hydrolase....Pages 79-81 ADP-dependent short-chain-acyl-CoA hydrolase....Pages 83-85 ADP-dependent medium-chain-acyl-CoA hydrolase....Pages 87-89 Acyl-CoA hydrolase....Pages 91-96 [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase....Pages 97-100 Myosin-light-chain-phosphatase....Pages 101-105 Fructose-2,6-bisphosphate 6-phosphatase....Pages 107-110 Caldesmon-phosphatase....Pages 111-113 Inositol-1,4,5-trisphosphate 5-phosphatase....Pages 115-122 Inositol-1,4-bisphosphate 1-phosphatase....Pages 123-126 Sugar-terminal-phosphatase....Pages 127-129 Alkylacetylglycerophosphatase....Pages 131-133 Phosphoenolpyruvate phosphatase....Pages 135-138 Inositol-1,4,5-trisphosphate 1-phosphatase....Pages 139-141 Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase....Pages 143-146 2-Carboxy-D-arabinitol-1-phosphatase....Pages 147-150 Phosphatidylinositol 3-phosphatase....Pages 151-153 Inositol-1,3-bisphosphate 3-phosphatase....Pages 155-157 Inositol-3,4-bisphosphate 4-phosphatase....Pages 159-161 Glycerophosphodiester phosphodiesterase....Pages 163-165 Variant-surface-glycoprotein phospholipase C....Pages 167-171 Dolichyl-phosphate-glucose phosphodiesterase....Pages 173-175 Dolichyl-phosphate-mannose phosphodiesterase....Pages 177-179 Glycoprotein phospholipase D....Pages 181-184 Glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase....Pages 185-187 Monomethyl-sulfatase....Pages 189-191 D-Lactate-2-sulfatase....Pages 193-195 Glucuronate-2-sulfatase....Pages 197-200 Aryldialkylphosphatase....Pages 201-206 Diisopropyl-fluorophosphatase....Pages 207-212 Deoxyribonuclease X....Pages 213-215 Ribonuclease IX....Pages 217-219 tRNA-intron endonuclease....Pages 221-224 rRNA endonuclease....Pages 225-227 1,3-alpha-L-Fucosidase....Pages 229-232 2-Deoxyglucosidase....Pages 233-235 Mannosyl-oligosaccharide 1,2-alpha-mannosidase....Pages 237-245 Mannosyl-oligosaccharide 1,3–1,6-alpha-mannosidase....Pages 247-253 Branched-dextran exo-1,2-alpha-glucosidase....Pages 255-257 Glucan 1,4-alpha-maltotriohydrolase....Pages 259-262 Amygdalin beta-glucosidase....Pages 263-266 Prunasin beta-glucosidase....Pages 267-270 Vicianin beta-glucosidase....Pages 271-274 Oligoxyloglucan beta-glycosidase....Pages 275-277 Polymannuronate hydrolase....Pages 279-281 Maltose-6’-phosphate glucosidase....Pages 283-285 Endoglycosylceramidase....Pages 287-292 3-Deoxy-2-octulosonidase....Pages 293-295 Raucaffricine beta-glucosidase....Pages 297-299 Coniferin beta-glucosidase....Pages 301-304 1,6-alpha-L-Fucosidase....Pages 305-307 Glycyrrhizinate beta-glucuronidase....Pages 309-312 Endo-alpha-sialidase....Pages 313-316 Glycoprotein endo-alpha-1,2-mannosidase....Pages 317-320 Xylan alpha-1,2-glucuronosidase....Pages 321-323 Chitosanase....Pages 325-331 Glucan 1,4-alpha-maltohydrolase....Pages 333-335 Difructose-anhydride synthase....Pages 337-339 Neopullulanase....Pages 341-344 Glucuronoarabinoxylan endo-1,4-beta-xylanase....Pages 345-348 Mannan exo-1,2–1,6-alpha-mannosidase....Pages 349-351 Anhydrosialidase....Pages 353-355 DNA-3-methyladenine glycosidase I....Pages 357-360 DNA-3-methyladenine glycosidase II....Pages 361-364 rRNA N-glycosidase....Pages 365-370 Formamidopyrimidine-DNA glycosidase....Pages 371-374 ADP-ribosyl-[dinitrogen reductase] hydrolase....Pages 375-378 Leukotriene-A 4 hydrolase....Pages 379-384 Hepoxilin-epoxide hydrolase....Pages 385-387 Methionyl aminopeptidase....Pages 389-394 D-Stereospecific aminopeptidase....Pages 395-398 Aminopeptidase Ey....Pages 399-402 Non-stereospecific dipeptidase....Pages 403-406 Cytosol nonspecific dipeptidase....Pages 407-413 Membrane dipeptidase....Pages 415-421 beta-Ala-His dipeptidase....Pages 423-426 Tripeptidyl-peptidase l....Pages 427-430 Tripeptidyl-peptidase ll....Pages 431-436 X-Pro dipeptidyl-peptidase....Pages 437-443 Peptidyl-dipeptidase B....Pages 445-448 Peptidyl-dipeptidase Dcp....Pages 449-452 Carboxypeptidase C....Pages 453-462 Carboxypeptidase D....Pages 463-467 Glutamate carboxypeptidase....Pages 469-473 Carboxypeptidase M....Pages 475-478 Muramoyltetrapeptide carboxypeptidase....Pages 479-482 Zinc D-Ala-D-Ala carboxypeptidase....Pages 483-485 Carboxypeptidase A 2 ....Pages 487-489 Membrane Pro-X carboxypeptidase....Pages 491-494 Tubulinyl-Tyr carboxypeptidase....Pages 495-497 Carboxypeptidase T....Pages 499-502 Carboxypeptidase Taq....Pages 503-506 beta-Aspartyl-peptidase....Pages 507-510 Pyroglutamyl-peptidase II....Pages 511-515 N-Formylmethionyl-peptidase....Pages 517-520 Pteroylpoly-gamma-glutamate carboxypeptidase....Pages 521-528 gamma-Glu-X carboxypeptidase....Pages 529-537 Acylmuramoyl-Ala peptidase....Pages 539-542 gamma-D-Glutamyl-meso-diaminopimelate peptidase I....Pages 543-546 Endopeptidase La....Pages 547-557 gamma-Renin....Pages 559-561 Venombin AB....Pages 563-567 Leucyl endopeptidase....Pages 569-572 Tryptase....Pages 573-583 Scutelarin....Pages 585-588 Kexin....Pages 589-593 Subtilisin....Pages 595-607 Oryzin....Pages 609-616 Endopeptidase K....Pages 617-622 Thermomycolin....Pages 623-627 Thermitase....Pages 629-634 Endopeptidase So....Pages 635-638 t-Plasminogen activator....Pages 639-644 Protein C (activated)....Pages 645-650 Pancreatic endopeptidase E....Pages 651-655 Pancreatic elastase II....Pages 657-659 IgA-specific serine endopeptidase....Pages 661-664 u-Plasminogen activator....Pages 665-671 Venombin A....Pages 673-678 Furin....Pages 679-686 Myeloblastin....Pages 687-691 Semenogelase....Pages 693-696 Granzyme A....Pages 697-701 Granzyme B....Pages 703-706 Streptogrisin A....Pages 707-710 Streptogrisin B....Pages 711-714 Glutamyl endopeptidase II....Pages 715-718 Oligopeptidase B....Pages 719-723 Limulus clotting factor C....Pages 725-728 Limulus clotting factor B....Pages 729-731 Limulus clotting enzyme....Pages 733-735 Omptin....Pages 737-740 Repressor LexA....Pages 741-744 Signal peptidase I....Pages 745-752 Togavirin....Pages 753-755 Flavivirin....Pages 757-760 Endopeptidase Clp....Pages 761-767 Proprotein convertase 1....Pages 769-772 Proprotein convertase 2....Pages 773-775 The objective of the Enzyme Handbook is to provide in concise form data on enzymes sufficiently well characterized. The data sheets are arranged in their EC number sequence, volumes 15 to 17 contain Additional Enzymes and updated data sheets to be inserted in previous volumes by their EC-number. For each enzyme, systematic and common names are given, information on reaction type, substrate and product spectrum, inhibitors, cofactors, kinetic data, pH and temperature range, origin, purification, molecular data and storage conditions are listed. A reference list completes the data sheets. This collection is an indispensable source of information for researchers applying enzymes in analysis, synthesis and biotechnology