Engineering 3d Tissue Test Systems

"Engineering 3D Tissue Test Systems provides an introduction to, and unique coverage of, a rapidly evolving area in biomaterials engineering. It reveals the current and future research responses, the current and future diagnostic applications, and provides a comprehensive overview to foster innovation. It offers insight into the importance of 3D systems and their use as benchtop models, spanning applications from basic scientific research to clinical diagnostics. Methods and limitations of building 3D tissue structures are evaluated, with attention given to the cellular, polymeric, and fabrication instrumentation components. The book covers the important aspects of polymeric tissue test systems, highlighting the needs and constraints of the industry, and includes a chapter on regulatory and pricing issues."--Provided by publisher Cover 1 Half Title 2 Title Page 4 Copyright Page 5 Dedication 6 Contents 8 Preface 12 Acknowledgments 14 Editors 16 Contributors 18 Reviewers 22 Chapter 1: Introduction to 3D Test Systems 24 Section I: Biofabrication Considerations 30 Chapter 2: Biofabrication 32 Chapter 3: Bioreactor Instrumentation and Control for 3D Cellular and Tissue Systems 56 Chapter 4: Control of 3D Environment: Redesign of the Flow Loop Bioreactor to Control Mitral Valve Regurgitation 84 Chapter 5: Nipple and Breast Construction: In Vitro and In Vivo Assessment 98 Chapter 6: 3D Cancer Spheroid Biofabrication Using Thermal Inkjet-Based Bioprinting for Rapid Screening 114 Section II: Materials Considerations 128 Chapter 7: Control Testing and Effect of Manufacturing Parameters on the Biocompatibility of Polypropylene Mesh Implants 130 Chapter 8: Scaffolds for 3D Model Systems in Bone Regenerative Engineering 148 Chapter 9: Engineered Composites for 3D Mammary Tissue Systems 164 Chapter 10: Mineralized 3D Culture Systems for Studying Bone Metastatic Breast Cancer 192 Chapter 11: Design Considerations for 3D Cardiovascular Tissue Scaffolds 216 Section III: Biological Considerations 236 Chapter 12: Pro- and Anti-Inflammatory Cytokine Signaling within 3D Tissue Models 238 Chapter 13: Cell–Cell Communications through Gap Junctions and Cancer in 3D Systems 256 Chapter 14: Advances in Breast Stem Cell Knowledge through 3D Systems 272 Chapter 15: Shape Matters: Understanding the Breast through 3D Tissue Culture Models 286 Chapter 16: Cells and Tissue Structures in Cardiovascular 3D Tissue Systems 308 Chapter 17: Signaling and Architectural Cues Necessary for 3D Diabetic Tissue Models 322 Chapter 18: Optimizing 3D Models of Engineered Skeletal Muscle 344 Chapter 19: Recapitulating the Microenvironment of Glioblastoma Multiforme Using 3D Tissue Culture Models 374 Section IV: Business Considerations 400 Editor’s Note on Business Considerations 400 Chapter 20: Bringing Regenerative Medicine to Patients: The Coverage, Coding, and Reimbursement Processes 404 Index 424 Editors, Karen J.l. Burg, Didier Dréau, And Timothy Burg. A Crc Title, Part Of The Taylor & Francis Imprint, A Member Of The Taylor & Francis Group, The Academic Division Of T & F Informa Plc. Includes Bibliographical References And Index.