Energy Metabolism and Lifespan Determination (Volume 14) (Advances in Cell Aging and Gerontology, Volume 14)

Experts in the fields of energy metabolism, aging and oxidative stress provide an integrated view of how mechanisms involved in regulating energy metabolism are linked to fundamental processes of aging including cellular stress resistance and free radical production. During evolution signal transduction pathways and organ systems have been optimised for the efficient seeking, ingestion, storing and using of energy. These signalling pathways play prominent roles in lifespan determination with insulin and related signalling pathways being prime examples. The authors consider how lifespan and healthspan can be extended through knowledge of energy metabolism with the experimental model of dietary restriction being one example. The information in this volume of ACAG will foster novel approaches and experiments for further understanding the roles of energy metabolism in aging and disease. Content: Table of Contents Pages v-vi Preface Pages vii-viii The search for energy: a driving force in evolution and aging Review Article Pages 1-11 Mark P. Mattson Insulin signaling, glucose metabolism oxidative stress, and aging Review Article Pages 13-33 Francesco S. Facchini Oxidative phosphorylation, mitochondrial proton cycling, free-radical production and aging Review Article Pages 35-68 John R. Speakman Protein turnover, energy metabolism, aging, and caloric restriction Review Article Pages 69-86 Stephen R. Spindler, Joseph M. Dhahbi, Patricia L. Mote Cellular and molecular mechanisms whereby dietary restriction extends healthspan: a beneficial type of stress Review Article Pages 87-103 Mark P. Mattson, Wenzhen Duan, Ruiqian Wan, Zhihong Guo Mitochondrial oxidative stress and caloric restriction Review Article Pages 105-122 Ricardo Gredilla, Gustavo Barja Understanding the aging fly through physiological genetics Review Article Pages 123-141 Fanis Missirlis Metabolism and life span determination in C. elegans Review Article Pages 143-175 Koen Houthoofd, Bart P Braeckman, Jacques R Vanfleteren Electron transport and life span in C. elegans Review Article Pages 177-195 Naoaki Ishii, Philip S Hartman Cellular glucose sensing, energy metabolism, and aging in Saccharomyces cerevisiae Review Article Pages 197-213 Stephen S. Lin, Jill K. Manchester, Jeffrey I. Gordon List of Contributors Pages 215-216 Considers how lifespan and healthspan can be extended through knowledge of energy metabolism with the experimental model of dietary restriction being one example. The information in this volume of ACAG fosters novel approaches and experiments for further understanding the roles of energy metabolism in aging and disease.