Endocrinology of the Lung: Development and Surfactant Synthesis (Contemporary Endocrinology)

During the past thirty years, great progress has been made in defining the roles of steroid, peptide, and polypeptide hormones in the processes of lung morphogenesis, differentiation of specialized cell types, and surfactant synthesis. In Endocrinology of the Lung, Carole Mendelson has assembled a panel of leading investigators to critically review the roles of various classes of endocrine, paracrine, and neuroendocrine factors in the regulation of lung development and surfactant production. Special attention is accorded the actions of glucocorticoids in lung branching morphogenesis and the synthesis of surfactant glycerophospholipids and proteins. Also extensively examined are the roles of cell-cell interactions and the elaboration of various growth factors and bioactive peptides in pulmonary cell differentiation, gene expression, and pathophysiology. The model systems utilized in these studies range from whole animal to transgenic and gene-targeted mice, to organ and cell culture. State-of-the-art and comprehensive, Endocrinology of the Lung constitutes a powerful new standard guide that illuminates the complex endocrinology of the lung for investigators actively studying hormone action in pulmonary biology and medicine today. Front Matter....Pages i-xi The Glucocorticoid Domain in the Lung and Mechanisms of Action....Pages 1-44 Fetal Responses to Glucocorticoids....Pages 45-57 Cyclic Adenosine Monophosphate and Glucocorticoid Regulation of Surfactant Protein-A Gene Expression....Pages 59-80 Hormonal Regulation of Surfactant Protein-B and Surfactant Protein-C Gene Expression in Fetal Lung....Pages 81-90 Glucocorticoid Regulation of Fatty Acid Synthase in Fetal Lung....Pages 91-104 The Genetics of Glucocorticoid-Regulated Embryonic Lung Morphogenesis....Pages 105-124 Corticotropin-Releasing Hormone and the Lung....Pages 125-140 Sex Differences in Fetal Lung Development....Pages 141-159 Retinoids and Lung Development....Pages 161-179 Insulin and Lung Development....Pages 181-200 The Insulin-like Growth Factor System and Lung....Pages 201-224 Platelet-Derived Growth Factor and Lung Development....Pages 225-240 Transforming Growth Factor-β Receptor Signaling and Lung Development....Pages 241-254 Transgenic Mouse Models for the Study of Growth Factor Signaling During Lung Morphogenesis....Pages 255-267 Parathyroid Hormone-Related Protein....Pages 269-297 Role of Neuroendocrine Cells in Fetal and Postnatal Lung....Pages 299-336 Back Matter....Pages 337-344 Carole Mendelson has assembled a panel of leading investigators to critically review the various classes of endocrine, paracrine, and neuroendocrine factors that play a role in the regulation of lung development and surfactant production. Special attention is accorded the actions of glucocorticoids in lung development and the synthesis of surfactant glycerophospholipids and proteins. Also extensively treated are the roles of cell-cell interactions and the elaboration of various growth factors and bioactive peptides in pulmonary cell differentiation, gene expression, and pathophysiology. State-of-the-art and comprehensive, Endocrinology of the Lung constitutes a powerful new standard guide that illuminates the complex endocrinology of the lung for all those actively investigating hormone action in pulmonary biology and medicine today.