Endocrine Therapy And Growth Regulation Of Breast Cancer (recent Results In Cancer Research)

Key questions involved in the treatment of disseminated breast cancer are discussed in this well-presented overview. It is the result of an initiative taken by the Swiss Group for Clinical Cancer Research to reveal the most recent developments in experimental and clinical research. The topics discussed include: the comparison of in vitro cultures of epithelial cells with breast cancer cells, the effect of steroids and their antagonists, the involvement of suppressor genes in tumour progression, the modulation of transforming growth factors by estrogen, and prognostic factors such as cERB-2 and EGF-R in breast cancer. Front Matter....Pages I-IX New Aspects in the Molecular Growth Regulation of Mammary Tumors....Pages 1-3 In Vitro Cultures of Epithelial Cells from Healthy Breast Tissues and Cells from Breast Carcinomas....Pages 4-15 Effects of Steroids and Their Antagonists on Breast Cancer Cells: Therapeutic Implications....Pages 16-28 Estrogen-Induced Mitogens in Breast Cancer and Their Prognostic Value....Pages 29-31 Serum Tyrosine Kinase Activity and Neoplastic Disease....Pages 32-40 Ribosomal Protein S6 Kinase and PKC in Human Mammary Tumor Cells....Pages 41-50 Expression of the c-erbB-2 Proto-Oncogene Protein in Human Breast Cancer....Pages 51-56 Modulation by Estrogen and Growth Factors of Transforming Growth Factor-Alpha and Epidermal Growth Factor Receptor Expression in Normal and Malignant Human Mammary Epithelial Cells....Pages 57-69 Epidermal Growth Factor Receptor in Human Breast Cancer....Pages 70-77 The Transformation-Suppressive Function Is Lost in Tumorgenic Cells and Is Restored upon Transfer of a Suppressor Gene....Pages 78-89 Back Matter....Pages 90-92