Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies (Emerging Contaminants and Associated Treatment Technologies)

This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics. Front Matter ....Pages i-xxv Front Matter ....Pages 1-1 Physiology of Endocrine System and Related Metabolic Disorders (Anam Ahsan, Ajab Khan, Muhammad Asim Farooq, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wen-xia Tian)....Pages 3-41 Impaired Carbohydrate Metabolism in Metabolic Disorders (Hina Sharif, Kanwal Rehman, Muhammad Sajid Hamid Akash, Kanwal Irshad, Ghulam Murtaza)....Pages 43-55 Mitochondrial Dysfunction in Metabolic Disorders (Ghulam Murtaza, Muhammad Tariq, Ramzi Shawahna)....Pages 57-68 Inherited Metabolic Disorders: A Current Status (Muhammad Shahid, Arslan Rasool, Fozia Anjum)....Pages 69-82 Impaired Lipid Metabolism in Metabolic Disorders (Kamran Haider, Kanwal Rehman, Muhammad Sajid Hamid Akash)....Pages 83-94 Impaired Thyroid Function in Metabolic Disorders (Yusra Habib Khan, Amna Saifullah, Tauqeer Hussain Mallhi, Allah Bukhsh, Tahir Mehmood Khan)....Pages 95-110 Front Matter ....Pages 111-111 Endocrine-Disrupting Chemicals: Occurrence and Exposure to the Human Being (Qurat UL Ain, Debmalya Roy, Anam Ahsan, Muhammad Asim Farooq, Md Aquib, Zahid Hussain et al.)....Pages 113-123 Antibiotic Resistance in EDCs-Induced Metabolic Disorders (Hina Sharif, Kanwal Rehman, Kanwal Irshad, Muhammad Sajid Hamid Akash)....Pages 125-133 Alteration of Gut Microbiota in EDCs-Induced Metabolic Disorders (Fareeha Fiayyaz, Kanwal Rehman, Hina Sharif, Kanwal Irshad, Shagufta Kamal, Muhammad Sajid Hamid Akash)....Pages 135-145 Endocrine Disrupting Chemicals Induced Childhood Obesity (Tauqeer Hussain Mallhi, Aisha Khokhar, Yusra Habib Khan, Nasser Hadal Alotaibi, Amjad Khan)....Pages 147-160 Role of Polychlorinated Biphenyls as EDCs in Metabolic Disorders (Waseem Hassan, Hammad Ahmed, Ghulam Murtaza, Muhammad Ihtisham Umar, Furqan Muhammad Iqbal)....Pages 161-174 Role of Furans as EDCs in Metabolic Disorders (Saima Muzammil, Asma Ashraf, Aqsa Muzammil, Rahat Andleeb, Azhar Rafique)....Pages 175-202 Role of Heavy Metals in Metabolic Disorders (Kanwal Irshad, Kanwal Rehman, Fareeha Fiayyaz, Hina Sharif, Ghulam Murtaza, Shagufta Kamal et al.)....Pages 203-219 Role of Flame-Retardants as EDCs in Metabolic Disorders (Talib Hussain, Abid Mehmood Yousaf, Muhammad Usman Ghori, Ikram Ullah Khan, Tahir Ali Chohan, Syed A. A. Rizvi et al.)....Pages 221-238 Role of Phthalates as EDCs in Metabolic Disorders (Tahir Farooq, Arruje Hameed, Ali Raza)....Pages 239-250 Bisphenol A as an EDC in Metabolic Disorders (Kanwal Irshad, Kanwal Rehman, Hina Sharif, Muhammad Tariq, Ghulam Murtaza, Muhammad Ibrahim et al.)....Pages 251-263 Role of Pesticides as EDCs in Metabolic Disorders (Shagufta Kamal, Muhammad Junaid, Ismat Bibi, Saima Rehman, Kanwal Rehman, Muhammad Sajid Hamid Akash)....Pages 265-300 Role of Perfluoroalkyl Substances as EDCs in Metabolic Disorders (Samia Gul Niazi, Chanda Javed, Adeel Shah, Qurat UL Ain, Imtiaz Mahmood Tahir)....Pages 301-322 Role of Polycyclic Aromatic Hydrocarbons as EDCs in Metabolic Disorders (Ajab Khan, Anam Ahsan, Muhammad Asim Farooq, Muhammad Naveed, Hongquan Li)....Pages 323-341 Tobacco Smoking as an EDC in Metabolic Disorders (Komal Jabeen, Muhammad Sajid Hamid Akash, Kamran Haider, Amna Faheem, Muhammad Tariq, Kanwal Rehman)....Pages 343-355 Role of Pharmaceuticals as EDCs in Metabolic Disorders (Arruje Hameed, Tahir Farooq, Sadia Shabbir)....Pages 357-365 Parabens as Endocrine Disrupting Chemicals and Their Association with Metabolic Disorders (Kamran Haider, Kanwal Rehman, Anam Sabbir, Muhammad Sajid Hamid Akash)....Pages 367-379 Role of Aflatoxins as EDCs in Metabolic Disorders (Shakila Sabir, Kanwal Rehman, Fareeha Fiayyaz, Shagufta Kamal, Muhammad Sajid Hamid Akash)....Pages 381-389 Front Matter ....Pages 391-391 Hormone Harmony in Metabolic Disorders (Nizwa Itrat)....Pages 393-408 Role of Nanoparticles in the Management of Metabolic Disorders (Zoya Iqbal, Muhammad Ibrahim, Ghulam Murtaza)....Pages 409-441 Intermittent Fasting for Treatment of Metabolic Disorders (Nizwa Itrat)....Pages 443-456 Herbs and Spices as Natural Medicine for Treatment of Metabolic Disorders (Nizwa Itrat)....Pages 457-488 Bioactive Compounds for the Treatment of Metabolic Disorders (Tauqeer Hussain Mallhi, Maria Rasheed, Yusra Habib Khan, Abdulaziz Ibrahim Alzarea, Ahsan Aftab Raja)....Pages 489-505 Correction to: Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies (Muhammad Sajid Hamid Akash, Kanwal Rehman, Muhammad Zaffar Hashmi)....Pages C1-C1 Back Matter ....Pages 507-520