Endemic Goiter : the Adaptation of Man to Iodine Deficiency

Goitrous patients in the Argentina area form the subject of this book. The authors have tried to define in quantitative terms the adaptive changes that occur when the thyroid gland seeks to compensate for iodine deficiency. In addition, the metabolism of iodine as disclosed by studies with radioactive iodine has been examined in detail. An attempt has been made to give a thorough account of the dynamic processes involved in thyroid-hormone synthesis and secretion and the factors that govern the rate constants involved. Finally, future areas of productive research suggested by the studies that were done have been outlined. ACKNOWLEDGMENTS CONTENTS FOREWORD PART I. INTRODUCTORY 1. THE MENDOZA ENDEMIC 2. METHODS 3. PATHWAYS OF IODINE METABOLISM PART II. FUNCTIONAL INTERRELATIONS 4. THE UPTAKE AND EXCRETION OF IODINE IN THE MENDOZA PATIENTS 5. THE EFFECTS OF SUPPLEMENTARY IODIDE ON THE RETENTION OF IODINE 6. THE EFFECTS OF DESICCATED THYROID 7. ADDITIONAL OBSERVATIONS PART III. DYNAMICS OF IODINE METABOLISM 8. THEORETICAL ASPECTS OF IODINE METABOLISM 9. THE METABOLISM OF IODINE IN THE MENDOZA PATIENT 10. THE EFFECTS OF METHIMAZOLE AND THYROTROPIN 11. THE EFFECT OF LARGE DOSES OF IODIDE ON THE METABOLISM OF IODINE 12. RECAPITULATION AND SUGGESTED STUDIES APPENDIX A. GLOSSARY APPENDIX B. APPROXIMATE SOLUTIONS FOR THE DIFFERENTIAL EQUATIONS OF THE THREE-COMPARTMENT MODEL INDEX