Emerging Viruses

New epidemics such as AIDS and "mad cow" disease have dramatized the need to explore the factors underlying rapid viral evolution and emerging viruses. This comprehensive volume is the first to describe this multifaceted new field. It places viral evolution and emergence in a historical context, describes the interaction of viruses with hosts, and details the advances in molecular biology and epidemiology that have provided the tools necessary to track developing viral epidemics and to detect new viruses far more successfully than could be done in the recent past. This unique book also lucidly details case histories and offers practical suggestions for the prevention of future epidemics. The contributors are leading authorities in their disciplines, and were selected both for their expert knowledge and for their ability to define and elucidate the fundamental issues. The book is highly accessible and has been written for a wide audience that includes virologists, public health authorities, medical anthropologists, evolutionary biologists, geneticists, infectious disease specialists, and social scientists interested in medical and health issues. Viruses and humankind: intracellular symbiosis and evolutionary competition / Joshua Lederberg Examining the origins of emerging viruses / Stephen S. Morse Viral emergence in historical context Patterns of disease emergence in history / William H. McNeill Influenza / Robert G. Webster Emerging viruses in context: an overview of viral hemorrhagic fevers / Karl M. Johnson Viruses and the host Ecology and evolution of host-virus associations / Robert M. May Pathogenesis of viral infections / Bernard N. Fields Virus and cell: determinants of tissue tropism / Thomas E. Shenk Seeing the unseen: methods for detecting viruses Virus detection systems / Douglas D. Richman New technologies for virus detection / David C. Ward Tracking emerging viruses Assessing geographic and transport factors, and recognition of new viruses / Robert E. Shope and Alfred S. Evans Phylogenetic moments in the AIDS epidemic / Gerald Myers, Kersti MacInnes and Lynda Myers. (cont) Ecological sources of emerging viruses Arthropod-borne viruses / Thomas P. Monath Hantaan (Korean Hemorrhagic Fever) and related rodent zoonoses / James W. LeDuc ... [et al.] Filoviruses / C.J. Peters ... [et al.] Interspecies transfer: case studies of animal viruses that recently crossed species Human monkeypox, a newly discovered human virus disease / Frank Fenner Seal plague virus / Brian W.J. Mahy Canine parvovirus 2: a probable example of interspecies transfer / Colin R. Parrish How viruses evolve: variation and evolution of RNA viruses Replication error, quasispecies populations, and extreme evolution rates of RNA viruses / John Holland High rate of retrovirus variation results in rapid evolution / Howard M. Temin Evolution of influenza and RNA viruses / Peter Palese Factors restraining emergence of new influenza viruses / Brian Murphy Recombination in the evolution of RNA viruses / James H. Strauss Evolutionary relationships of vectors and viruses / Bruce F. Eldridge. (cont) Prospects for the future Global change and epidemiology: nasty synergies / Thomas E. Lovejoy Are we prepared for a viral epidemic emergency? / Llewellyn J. Legters, Linda H. Brink and Ernest T. Takafuji Surveillance systems and intergovernmental cooperation / Donald A. Henderson Afterword: a personal summary presented as a guide for discussion / Edwin D. Kilbourne. Annotation New epidemics such as AIDS and "mad cow" disease have dramatized the need to explore the factors underlying rapid viral evolution and emerging viruses. This comprehensive volume is the first to describe this multifaceted new field. It places viral evolution and emergence in a historicalcontext, describes the interaction of viruses with hosts, and details the advances in molecular biology and epidemiology that have provided the tools necessary to track developing viral epidemics and to detect new viruses far more successfully than could be done in the recent past. This unique bookalso lucidly details case histories and offers practical suggestions for the prevention of future epidemics. The contributors are leading authorities in their disciplines, and were selected both for their expert knowledge and for their ability to define and elucidate the fundamental issues. Thebook is highly accessible and has been written for a wide audience that includes virologists, public health authorities, medical anthropologists, evolutionary biologists, geneticists, infectious disease specialists, and social scientists interested in medical and health issues New epidemics such as AIDS and 'mad cow' disease have dramatized the need to explore the factors underlying rapid viral evolution and emerging viruses. Now available in paperback, this comprehensive book is the first to describe this multifaceted new field. The book places viral evolution and emergence in a historical context, describes the interaction of viruses with hosts, and details the advances in molecular biology and epidemiology that have provided the tools necessary to track developing viral epidemics and to detect new viruses far more successfully than could be done in the recent past. Case histories and practical suggestions for the prevention of future epidemics are given. From reviews of the hardback: "excellent examples of emerging virus diseases ... an excellent training resource, and should be required reading for all infectious disease and public health professionals This is the first book to focus on rapid viral evolution and emerging viruses. With such new diseases as AIDS and `mad cow' disease, the subject attracts immediate and widespread attention. Based on a symposium, this book has been edited to appeal to a fairly broad professional audience. A reference work that focuses on rapid viral evolution and such emerging viruses as mad cow disease and AIDS. It examines the interaction of viruses with hosts, advances in molecular biology and epidemiology which help to track viral infections, and ways of preventing future epidemics This Is The First Book To Focus On Rapid Viral Evolution And Emerging Viruses. It Systematically Explores Methods To Track Viral Epidemics And To Detect New Viruses. It Also Offers Practical Suggestions For The Prevention Of Future Epidemics.