Eicosanoids, Aspirin, and Asthma (Lung Biology in Health & Disease) (Lung Biology in Health and Disease, V. 114)

Presents new ideas on the molecular biology, biochemistry, crystallography, and pharmacology of eicosanoids, including their interaction with antiinflammatory drugs and their influence on the mechanisms of asthma. Surveys a rich panorama of clinical symptoms from the European Network on Aspirin-Induced Asthma, the largest database of its kind in the world. Blending Basic Science With The Latest Clinical Insights, This Book Presents New Ideas On The Molecular Biology, Biochemistry, Crystallography, And Pharmacology Of Eicosanoids, Including Their Interaction With Anti-inflammatory Drugs And Their Influence On The Mechanisms Of Asthma.--jacket. Introduction / Claude Lenfant -- 1. Mechanism Of Action Of Antiinflammatory Drugs / John R. Vane And Regina M. Botting -- 2. Pathways Of Arachidonate Metabolism / John C. Mcgiff And Michael Balazy -- 3. Cytochromes P450 And Arachidonic Acid Metabolism / Michael Balazy And John C. Mcgiff -- 4. Mechanisms Of Isoprostane Biosynthesis In Humans / Paola Patrignani, Roberto Padovano And Maria Gina Sciulli -- 5. Intracellular Localization Of Eicosanoid-forming Enzymes / Thomas G. Brock And Marc Peters-golden -- 6. Cyclooxygenase-2 Expression In Airway Cells / Peter J. Barnes, Maria G. Belvisi And Robert Newton -- 7. Cyclooxygenase Gene Expression And Regulation / Kenneth Kun-yu Wu -- 8. Nsaid-induced Apoptosis: A New Therapeutic Activity Of Competitive Cyclooxygenase Inhibitors? / Daniel L. Simmons -- 9. The Three-dimensional Structure Of Cyclooxygenases / Daniel Picot --^ 10. The Role Of 5-lipoxygenase Products In A Mouse Model Of Allergic Airway Inflammation / Colin D. Funk And Xin-sheng Chen / Charles G. [and Others] -- 11. Genetic Influences On Asthma / William O.c.m. Cookson -- 12. Intrinsic Asthma / Leonardo M. Fabbri, Gaetano Caramori And Bianca Beghe -- 13. Viral Infection And Asthma: The Modulatory Role Of Nitric Oxide On Prostaglandin H Synthase / Gert Folkerts And Frans P. Nijkamp -- 14. The Pharmacology Of Prostaglandin E[subscript 2]: Actions In Human Diseases Involving The Mast Cell / John A. Oates, John J. Murray And David D. Hagaman -- 15. Eicosanoids In The Pathogenesis Of Exercise- And Allergen-induced Asthma / Paul M. O'byrne -- 16. Endotoxin-induced Acute Respiratory Distress Syndrome In Nitric Oxide-deficient Rats / Pawel P. Wolkow, Ewa Janowska And Joanna B. Bartus -- 17. Eicosanoid Regulation By Glucocorticoids In Asthma / Ryszard Dworski -- 18. Mechanisms Of Aspirin-induced Asthma / Andrzej Szczeklik --^ 19. Leukotrienes In Aspirin-sensitive Asthma / S.m. Shuaib Nasser And Tak H. Lee -- 20. Mast Cell And Eosinophil Responses After Indomethacin In Asthmatics Tolerant And Intolerant To Aspirin / Esther L. Langmack And Sally E. Wenzel -- 21. Aspects Of Mechanisms In Aspirin-intolerant Asthma / Barbro Dahlen -- 22. Aspirin-intolerant Asthma: New Insights From Bronchial Mucosal Biopsies / Anthony P. Sampson -- 23. Pharmacological Intervention In Generation Of Leukotrienes By Eosinophils / Klaus F. Rabe And Gordon Dent -- 24. Airway Ion Transport Mechanisms And Aspirin In Asthma / Sebastiano Bianco, Maria Robuschi And Andriano Vaghi -- 25. Role Of Autoantibodies Against Endothelial Cells In Severe Asthma / Philippe Lassalle, Michel Joseph And Andre-bernard Tonnel -- 26. Clinical Course Of Aspirin-induced Asthma: Results Of Aiane / Ewa Nizankowska, Mariusz Duplaga And Grazyna Bochenek -- 27. Nasal Polyposis / Niels Mygind, Ronald Dahl And Per L. Larsen --^ 28. The Nose In Aspirin-sensitive Asthma / Cesar Picado And Joaquim Mullol -- 29. The Role Of Glucocorticoids In The Modulation Of Eicosanoid Metabolism In Asthma / Isabelle Vachier, Pascal Chanez And Claude Chavis -- 30. Desensitization In Aspirin-induced Asthma / Donald D. Stevenson. Edited By Andrzej Szczeklik, Ryszard J. Gryglewski, Sir John R. Vane. Includes Bibliographical References And Indexes.