Ehrlichiosis : A Vector-borne Disease of Animals and Humans

This book is a direct result of a symposium held in December 1988, in Washington, DC, honoring Professor Emeritus Miodrag Ristic for his contributions to rickettsial disease research, in general, and, to ehrlichiosis, in particular. He and his colleagues in the United States Army Medical Research Unit brought to the world's attention an epidemic of ehrlichiosis, that occurred in German shepherd dogs during the Vietnam War. The group was able to culture the microorganism Ehrlichia canis and to fulfill Koch's postulates. They eventually developed an indirect immunofluorescent antibody (IFA) test which has been adopted internationally. The same group joined a national effort to decipher another mysterious disease known as Potomac horse fever (PHF). They used the same technology developed by Nyindo in Dr. Ristic's laboratory to isolate, characterize, and again develop a similar IFA test for PHF. Today PHF has been diagnosed, at least serologically, practically across the entire United States, in some provinces of Canada, and reports are beginning to trickle in of its occurrence in European countries. Thus, the etiologic agent of PHF, now named after Professor Ristic, Ehrlichia risticii, historically places this scientist side by side with the other 2 "R's", i. e. , Ricketts and da Rochalima. Ehrlichiosis is not limited to domestic animals. Sennetsu rickettsiosis, long known by Japanese scientists as an imitator of "infectious mononucleosis," was subsequently shown to be caused by an ehrlichial agent, through collaborative efforts among the United States Army, the University of Illinois, and Dr. Front Matter....Pages i-xii The Historical Background and Global Importance of Ehrlichiosis....Pages 1-8 Current Status of the In-Vitro Cultivation of Ehrlichiae....Pages 9-21 Ultrastructure of Rickettsiae with Special Emphasis on Ehrlichiae....Pages 22-31 Antigenic Properties of the Ehrlichiae and other Rickettsiaceae....Pages 32-58 Biological Properties of the Genus Ehrlichia : Substrate Utilization and Energy Metabolism....Pages 59-67 Biologic and Pathogenic Properties of Ehrlichia Risticii : The Etiologic Agent of Equine Monocytic Ehrlichiosis....Pages 68-77 Pathophysiology of Canine Ehrlichiosis....Pages 78-92 Experimental Ehrlichiosis in Nonhuman Primates....Pages 93-99 Human Ehrlichiosis in the United States....Pages 100-111 Evolutionary History of Chlamydiae: Answers for Some Old Questions, No Answers for Some New Ones....Pages 112-124 Recent Research Findings on Cowdriosis....Pages 125-135 Current Strategies in Research on Ehrlichiosis....Pages 136-153 Epilogue....Pages 154-158 Back Matter....Pages 159-164