EDHF 2002 [proceedings of the ... Fourth International Symposium on Endothelium Derived Hyperpolarizing Factor ... held in Vaux de Cernay (France) from June 5 - 7, 2002

Understanding the nature and role of endothelium-derived hyperpolarizing factor appears to be crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion and other vascular disorders. EDHF 2002 contains the proceedings of the Fourth International Symposium on endothelium-dependent hyperpolarizations and will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases

Understanding the nature and role of endothelium-derived hyperpolarizing factor is crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion, and other vascular disorders. EDHF 2002 is based on the proceedings of the Fourth International Symposium on endothelium-dependent hyperpolarizations. It will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases.

1. Potassium Channels and Member Potential in Vascular Endothelial and Smooth Muscle Cells 2. Possible Contribution to CLCA1 to Calcium-Activated Chloride Channels in Murine Smooth Muscle Cells 3. Trafficking and Transduction Functions of the NA Pump in Vascular Smooth Muscle Cells 4. Isoforms of NA, K-Atpase 5. Calcium Sparks and Membrane Potential 6. Proteinase-Activated Receptor-2: Release of an Endothelium-Derived Hyperpolarizing Factor Distinct from that Released by Acetylcholine 7. Mechanical Stimulation Increases the Activity and Expression of Cytochrome P450 2C in Porcine Coronary Arte The plasma membranes of endothelial and vascular smooth muscle cells express unique populations of K+ channels, and the K+ currents generated by these channels regulate electromechanical coupling and contraction of the blood vessel wall.