Early Life Origins of Ageing and Longevity (Healthy Ageing and Longevity Book 9)

This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life. While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process. Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical __in-utero__ and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life. In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns. __Early Life Origins of Ageing and Longevity__ benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field. Front Matter ....Pages i-xi Front Matter ....Pages 1-1 Epidemiology of Early Nutrition and Adult Health: Metabolic Adaptations and Body Composition (Daniel J. Hoffman, Alessandro Bigoni, Adriana Carrieri)....Pages 3-22 General Biology of the Developmental Origins of Health (Michelle Lampl)....Pages 23-34 Front Matter ....Pages 35-35 Early Life Programming of Aging in Genetically Long-Lived Mice (Andrzej Bartke, Liou Sun)....Pages 37-55 Immunological Basis of In Utero Programming of Adult Disease (Thea N. Golden, Rebecca A. Simmons)....Pages 57-66 Early Life Developmental Programming of the GH/IGF Axis and Long-Term Health (Clare M. Reynolds, Mark H. Vickers)....Pages 67-86 Early Life Nutritional Programming of Adult Health Status (Simon C. Langley-Evans, Beverly Muhlhausler)....Pages 87-120 The Interplay Between Dopamine and Environment as the Biological Basis for the Early Origins of Mental Health (Barbara Barth, André K. Portella, Laurette Dubé, Michael J. Meaney, Patricia Pelufo Silveira)....Pages 121-140 The Developmental Origins of Osteoporosis (Clare Shere, Cyrus Cooper, Elaine M. Dennison)....Pages 141-165 Nutrigenomics as a Strategy for Neuronal Health (Elisabetta Damiani, Rosita Gabbianelli)....Pages 167-187 Front Matter ....Pages 189-189 Prenatal Undernutrition and Ageing and Longevity (Susanne R. de Rooij)....Pages 191-208 Influence of Maternal Obesity on the Long-Term Health of Offspring (Emma C. Johns, David Q. Stoye, Liu Yang, Rebecca M. Reynolds)....Pages 209-231 Prenatal Exposure to Famine and Ageing (Tessa J. Roseboom)....Pages 233-244 Why Is Parental Lifespan Linked to Children’s Chances of Reaching a High Age? A Transgenerational Hypothesis (Denny Vågerö, Vanda Aronsson, Bitte Modin)....Pages 245-267 Early-Life Adjustment of Epigenetic Aging Clock (Alexander Vaiserman, Oleh Lushchak)....Pages 269-282 Front Matter ....Pages 283-283 Public Health and Social Policy Perspectives on DOHaD (M. Lelinneth B. Novilla, Michael C. Goates, Michael D. Barnes, Justin M. Packer)....Pages 285-302 Back Matter ....Pages 303-310 "This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life. While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process. Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life. In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns. Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field" - prové de l'editor