Dupuytren' S Disease and Related Hyperproliferative Disorders: Principles, Research, and Clinical Perspectives

This book is based on results of the 2010 International Symposium on Dupuytren's disease held in Miami, Florida, but it also includes new data and additional chapters. It is hoped that it will raise awareness of this underestimated condition and promote cooperative efforts to work towards a cure. Up to date information is provided on the epidemiology, biology, and pathology of the disease. The principles and specifics of treatment are explored in detail. The indications for and techniques of radiotherapy, minimally invasive treatments and open surgery are fully explained. The role of physical therapy is considered as well as the care of relapse and complications. The treatment of Ledderhose’s disease and Peyronie’s disease is also discussed. This book provides invaluable information for hand surgeons, podiatrists, orthopedists, radiation therapy specialists and general practitioners. It will help to foster an interdisciplinary approach to the understanding and management of this debilitating disorder. Front Matter....Pages i-xxiii Front Matter....Pages 1-1 Dupuytren’s Disease: Anatomy, Pathology, and Presentation....Pages 3-10 Palmar Fibromatosis or the Loss of Flexibility of the Palmar Finger Tissue: A New Insight into the Disease Process of Dupuytren Contracture....Pages 11-20 Basic Thoughts on Dupuytren’s Contracture....Pages 21-26 High Prevalence of Dupuytren’s Disease and Its Treatment in the British National Health Service: An Ongoing Demand....Pages 27-34 Treatment for Dupuytren’s Disease: An Overview of Options....Pages 35-43 Dupuytren’s Disease and Occupation....Pages 45-49 Front Matter....Pages 51-51 The Role of the Myofibroblast in Dupuytren’s Disease: Fundamental Aspects of Contraction and Therapeutic Perspectives....Pages 53-60 Mechanisms of Myofibroblast Differentiation....Pages 61-67 Myofibroblasts and Interactions with Other Cells: Contribution of the Tissue Engineering....Pages 69-75 Dupuytren’s Contracture Versus Burn Scar Contracture....Pages 77-83 Front Matter....Pages 85-85 The Genetic Basis of Dupuytren’s Disease: An Introduction....Pages 87-91 Use of Genetic and Genomic Analyses Tools to Study Dupuytren’s Disease....Pages 93-100 Establishing an Animal Model of Dupuytren’s Contracture by Profiling Genes Associated with Fibrosis....Pages 101-108 Microarray Expression Analysis of Primary Dupuytren’s Contracture Cells....Pages 109-113 A Clinical Genetic Study of Familial Dupuytren’s Disease in the Netherlands....Pages 115-122 The Epidemiology of Dupuytren’s Disease in Bosnia....Pages 123-127 Front Matter....Pages 129-129 A Primer of Collagen Biology: Synthesis, Degradation, Subtypes, and Role in Dupuytren’s Disease....Pages 131-142 The Expression of Collagen-Degrading Proteases Involved in Dupuytren’s Disease Fibroblast-Mediated Contraction....Pages 143-149 Primary Dupuytren’s Disease Cell Interactions with the Extra-cellular Environment: A Link to Disease Progression?....Pages 151-159 Insulin-Like Growth Factor Binding Protein-6: A Potential Mediator of Myofibroblast Differentiation in Dupuytren’s Disease?....Pages 161-165 Front Matter....Pages 129-129 Dupuytren’s Disease Shows Populations of Hematopoietic and Mesenchymal Stem-Like Cells Involving Perinodular Fat and Skin in Addition to Diseased Fascia: Implications for Pathogenesis and Therapy....Pages 167-174 Using Laboratory Models to Develop Molecular Mechanistic Treatments for Dupuytren’s Disease....Pages 175-183 Front Matter....Pages 185-185 Plastic Surgical Management of Scars and Soft Tissue Contractures....Pages 187-193 Cline’s Contracture: Dupuytren Was a Thief – A History of Surgery for Dupuytren’s Contracture....Pages 195-205 Cellulose Implants in Dupuytren’s Surgery....Pages 207-211 Expanded Dermofasciectomies and Full-Thickness Grafts in the Treatment of Dupuytren’s Contracture: A 36-Year Experience....Pages 213-220 Minimizing Skin Necrosis and Delayed Healing After Surgical Treatment for Dupuytren’s Contracture: The Mini-Chevrons Incision....Pages 221-225 Skin Management in Treatment of Severe PIP Contracture by Homo- or Heterodigital Flaps....Pages 227-234 The “Jacobsen Flap” for the Treatment of Stage III–IV Dupuytren’s Disease at Little Finger: Our Review of 123 Cases....Pages 235-242 A Logical Approach to Release of the Contracted Proximal Interphalangeal Joint in Dupuytren’s Disease....Pages 243-248 The Influence of Dupuytren’s Disease on Trigger Fingers and Vice Versa....Pages 249-253 No Higher Self-Reported Recurrence in Segmental Fasciectomy....Pages 255-260 Palmar Cutaneous Branches of the Proper Digital Nerves Encountered in Dupuytren’s Surgery: A Cadaveric Study....Pages 261-263 Front Matter....Pages 265-265 A Technique of Needle Aponeurotomy for Dupuytren’s Contracture....Pages 267-279 Three-Year Results of First-Ever Randomized Clinical Trial on Treatment in Dupuytren’s Disease: Percutaneous Needle Fasciotomy Versus Limited Fasciectomy....Pages 281-288 Management of Dupuytren’s Disease with Needle Aponeurotomy: The Experience at the Hand and Upper Limb Centre, Canada....Pages 289-292 Percutaneous Needle Fasciotomy: A Serious Alternative?....Pages 293-296 Dynamic External Fixation in the Treatment of Dupuytren’s Contracture....Pages 297-303 Hand Therapy for Dupuytren’s Contracture....Pages 305-316 Severity of Contracture and Self-Reported Disability in Patients with Dupuytren’s Contracture Referred for Surgery....Pages 317-321 Front Matter....Pages 265-265 Night-Time Splinting After Fasciectomy or Dermofasciectomy for Dupuytren’s Contracture: A Pragmatic, Multi-centre, Randomised Controlled Trial....Pages 323-332 The Role of Static Night Splinting After Contracture Release for Dupuytren’s Disease: A Preliminary Recommendation Based on Clinical Cases....Pages 333-339 Front Matter....Pages 341-341 Injectable Collagenase ( Clostridium histolyticum ) for Dupuytren’s Contracture: Results of the CORD I Study....Pages 343-347 Long-Term Outcome of Radiotherapy for Early Stage Dupuytren’s Disease: A Phase III Clinical Study....Pages 349-371 Outcomes of Using Bioengineered Skin Substitute (Apligraf®) for Wound Coverage in Dupuytren’s Surgery....Pages 373-378 Highly Dosed Tamoxifen in Therapy-Resisting Dupuytren’s Disease....Pages 379-386 Screening of Prodrugs on Cells Grown from Dupuytren’s Disease Patients....Pages 387-391 Relaxin: An Emerging Therapy for Fibroproliferative Disorders....Pages 393-400 Cryotherapy and Other Therapeutical Options for Plantar Fibromatosis....Pages 401-407 Long-Term Outcome of Radiotherapy for Primary and Recurrent Ledderhose Disease....Pages 409-427 Medical Management of Peyronie’s Disease....Pages 429-437 Front Matter....Pages 439-439 The Patient’s Perspective and the International Dupuytren Society....Pages 441-447 IDUP: Proposal for an International Research Database....Pages 449-454 The Future of Dupuytren’s Research and Treatment....Pages 455-470 Back Matter....Pages 471-474 Until a cure exists, Dupuytren's disease and related disorders such as Ledderhose's disease will pose lifelong threats of functional impairment for affected individuals. A better understanding of the onset of disease, early detection and functional preservation are of the utmost importance to minimize the impact of these conditions. This book is based on presentations and discussions at the 2010 International Symposium on Dupuytren's disease held in Miami, Florida, but it also includes new data and additional chapters. It is hoped that it will raise awareness of this underestimated condition and promote cooperative efforts to work towards a cure. Up to date information is provided on the epidemiology, biology, and pathology of the disease. The principles and specifics of treatment are explored in detail. The indications for and techniques of radiotherapy, minimally invasive treatments and open surgery are fully explained. In addition, the role of physical therapy is considered as well as the care of relapse and complications. Treatment of Ledderhose's disease and Peyronie's disease is also discussed. This book provides invaluable information for hand surgeons, podiatrists, orthopedists, plastic surgeons, radiation therapy specialists and general practitioners. It will help to foster an interdisciplinary approach to the understanding and management of this debilitating disorder and related conditions Annotation Based on material from the first symposium for 40 years devoted to this disease, this volume, with up-to-date data on its epidemiology, biology, and pathology, aims to raise awareness of this underestimated condition and promote efforts to find a cure