Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer

This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing “true” DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer. Written by experts in the field, __Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer__ is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer. Front Matter....Pages i-xiii Epidemiology of Ductal Carcinoma In Situ....Pages 1-11 Role of Screening Mammography in Early Detection/Outcome of Breast Cancer....Pages 13-26 Imaging DCIS: Digital/Film-Screening Mammography, Tomosynthesis, MRI, Ultrasonography....Pages 27-37 Pathology of Ductal Carcinoma In Situ: Features and Diagnostic Challenges....Pages 39-49 Molecular Markers in DCIS....Pages 51-55 History of Ductal Carcinoma In Situ Management Based Upon Data from Prospective, Randomized Clinical Trials....Pages 57-65 Extent and Role of Margin Control for DCIS Managed by Breast-Conserving Surgery....Pages 67-83 Ductal Carcinoma In Situ Treated with Breast-Conserving Surgery Alone....Pages 85-90 DCIS Managed with BCS: Whole-Breast XRT vs. Partial Breast XRT....Pages 91-98 Anti-HER2/neu Therapy in DCIS....Pages 99-108 Role of Genetic Profiling and Recurrence Scores in Treatment Planning for DCIS....Pages 109-115 DCIS and Sentinel Lymph Node Biopsy....Pages 117-124 Role of Postmastectomy Radiation for DCIS....Pages 125-137 Monitoring and Surveillance Following DCIS Treatment....Pages 139-146 DCIS and Hereditary Susceptibility for Breast Cancer....Pages 147-154 Introduction, Evolution, and Application of the Van Nuys Prognostic Index in DCIS....Pages 155-160 Disparities in DCIS Detection and Outcomes Related to Race/Ethnicity....Pages 161-166 Back Matter....Pages 167-168 Epidemiology Of Ductal Carcinoma In Situ -- Role Of Screening Mammography In Early Detection/outcome From Breast Cancer -- Imaging Dcis: Digital/film Screening Mammography, Tomosynthesis, Mri, Ultrasonography -- Pathology Of Ductal Carcinoma In Situ: Features And Diagnostic Challenges -- Molecular Markers In Dcis -- History Of Ductal Carcinoma In Situ Management Based Upon Data From Prospective, Randomized Clinical Trials -- Extent And Role Of Margin Control For Dcis Managed By Breast-conserving Surgery -- Ductal Carcinoma In Situ Treated With Breast Conserving Surgery Alone -- Dcis Managed With Bcs: Whole-breast Xrt Vs. Partial Breast Xrt -- Anti-her2/neu Therapy In Dcis -- Role Of Genetic Profiling And Recurrence Scores In Treatment Planning For Dcis -- Dcis And Sentinel Lymph Node Biopsy -- Role Of Postmastectomy Radiation For Dcis -- Monitoring And Surveillance Following Dcis Treatment -- Dcis And Hereditary Susceptibility For Breast Cancer -- Introduction, Evolution And Application Of The Van Nuys Prognostic Index In Dcis -- Disparities In Dcis Detection And Outcomes Related To Race/ethnicity. Lisa A. Newman, Jessica M. Bensenhaver, Editors. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. This volume reviews the ℗levolution of information regarding the epidemiology of DCIS and its modes of detection, as well℗l as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing ĺltrueĺl DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer. Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer