Dubois' Lupus Erythematosus and Related Syndromes: Expert Consult - Online and Print

Recognized for more than 45 years as the definitive text in the field, Dubois'Lupus Erythematosus and Related Syndromes strikes the perfect balance between basic science and clinical expertise, providing the evidence-based findings, treatment consensuses, and practical clinical information you need to confidently diagnose and manage SLE. Broaden your understanding with comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes fundamental images of lupus rashes as well as graphs, algorithms, and differential diagnosis comparisons.Discover the latest in systemic lupus erythematosus with new chapters on important emerging topics such as socioeconomic and disability aspects; and rigorously updated chapters that include expanded coverage of the nervous system, and the most in-depth discussion of immunity and regulatory cells.Learn from the very best. World-renowned rheumatologists Drs. Daniel Wallace and Bevra Hannahs Hahn, along with new associate editors Drs. Michael Weisman, Ronald Van Vollenhoven, Nan Shen, and David Isenberg, present definitive coverage on new and rapidly changing areas in the field.Rely on it anytime, anywhere! Access the full text, image bank, and bonus online-only chapters at www.expertconsult.com.Dubois'Lupus Erythematosus was first published in 1966. For the past forty years, the product has distinguished itself internationally as the go-to reference on lupus and related diseases. For rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on systemic lupus erythematosus (SLE) and related disorders, this product delivers a complete arsenal of information on SLE, connective tissue diseases, and the antiphospholipid syndromes. Content: Front Matter , Pages i-iii Copyright , Page iv Contributors , Pages v-x , Joseph M. Ahearn, Cynthia Aranow, J. Antonio Aviña-Zubieta, Andre Barkhuizen, Sasha Bernatsky, Celine Berthier, Hendrika Bootsma, Lukas Bossaller, H.R. Bouma, Dimitrios T. Boumpas, Cherie L. Butts, Eliza F. Chakravarty, Benjamin F. Chong, Ann E. Clarke, Megan E.B. Clowse, José C. Crispín, Mary K. Crow, Maria Dall'Era, Anne Davidson, Yun Deng, et al. Preface , Page xi , Daniel J. Wallace, Bevra H. Hahn, Los Angeles Chapter 1 - Definition and Classification of Lupus and Lupus-Related Disorders , Pages 1-7 , Jinoos Yazdany, Maria Dall’Era Chapter 2 - The Epidemiology of Lupus , Pages 8-24 , S. Sam Lim, Cristina Drenkard Chapter 3 - The Pathogenesis of SLE , Pages 25-34 , Bevra H. Hahn Chapter 4 - Genetics of Human SLE , Pages 35-45 , Yun Deng, Betty P. Tsao Chapter 5 - Epigenetics of Lupus , Pages 46-56 , Nan Shen, Dong Liang, Yuajia Tang, Yuting Qin Chapter 6 - The Innate Immune System in SLE , Pages 57-61 , Lukas Bossaller, Ann Marshak-Rothstein Chapter 7 - Cytokines and Interferons in Lupus , Pages 62-75 , Mary K. Crow, Timothy B. Niewold, Kyriakos A. Kirou Chapter 8 - The Structure and Derivation of Antibodies and Autoantibodies , Pages 76-95 , Giovanni Franchin, Yong-Rui Zou, Betty Diamond Chapter 9 - T Cells , Pages 96-103 , José C. Crispín, George C. Tsokos Chapter 10 - Regulatory Cells in SLE , Pages 104-114 , Antonio La Cava Chapter 11 - Apoptosis, Necrosis, and Autophagy , Pages 115-126 , Keith B. Elkon Chapter 12 - Abnormalities in Immune Complex Clearance and Fcγ Receptor Function , Pages 127-140 , Jane E. Salmon, Robert P. Kimberly Chapter 13 - Neural-Immune Interactions: Principles and Relevance to SLE , Pages 141-151 , Cherie L. Butts, Esther M. Sternberg Chapter 14 - Complement and SLE , Pages 152-165 , Chau-Ching Liu, Susan Manzi, Joseph M. Ahearn Chapter 15 - Mechanisms of Acute Inflammation and Vascular Injury in SLE , Pages 166-174 , J. Michelle Kahlenberg, Mariana J. Kaplan Chapter 16 - Mechanisms of Tissue Damage—Free Radicals and Fibrosis , Pages 175-189 , Biji T. Kurien, Chandra Mohan, R. Hal Scofield Chapter 17 - Animal Models of SLE , Pages 190-236 , Bevra Hannahs Hahn, Dwight Kono Chapter 18 - Pathogenetic Mechanisms in Lupus Nephritis , Pages 237-255 , Anne Davidson, Celine Berthier, Matthias Kretzler Chapter 19 - Immune Tolerance Defects in Lupus , Pages 256-272 , Ram Raj Singh, Shweta Dubey, Julia Pinkhasov Chapter 20 - Autoantibodies , Pages 273-285 Chapter 21 - Autoantigenesis and Antigen-Based Therapy and Vaccination in SLE , Pages 286-303 , Ram Raj Singh, Julia Pinkhasov, Priti Prasad, Shweta Dubey Chapter 22 - Overview and Clinical Presentation , Pages 304-309 , Andrea Hinojosa-Azaola, Jorge Sánchez-Guerrero Chapter 23 - Pathomechanisms of Cutaneous Lupus Erythematosus , Pages 310-318 , Jan P. Dutz Chapter 24 - Skin Disease in Cutaneous Lupus Erythematosus , Pages 319-332 , Benjamin F. Chong, Victoria P. Werth Chapter 25 - The Musculoskeletal System and Bone Metabolism , Pages 333-340 , Sandra V. Navarra, Tito P. Torralba Chapter 26 - Pathogenesis and Treatment of Atherosclerosis in Lupus , Pages 341-351 , Maureen McMahon, Brian Skaggs, Jennifer Grossman Chapter 27 - Cardiopulmonary Disease in SLE , Pages 352-362 , Guillermo Ruiz-Irastorza, Munther Khamashta Chapter 28 - Pathogenesis of the Nervous System , Pages 363-367 , Cynthia Aranow, Betty Diamond, Meggan Mackay Chapter 29 - Clinical Aspects of the Nervous System , Pages 368-381 , Sterling G. West Chapter 30 - Psychopathology, Neurodiagnostic Testing, and Imaging , Pages 382-392 , John G. Hanly, Antonina Omisade, John D. Fisk Chapter 31 - Ocular, Aural, and Oral Manifestations , Pages 393-400 , James T. Rosenbaum, Dennis R. Trune, Andre Barkhuizen, Lyndell Lim Chapter 32 - Management of Sjögren Syndrome in Patients with SLE , Pages 401-414 , Hendrika Bootsma, Hjalmar R. Bouma, Frans G.M. Kroese, Arjan Vissink, Daniel J. Wallace Chapter 33 - Gastrointestinal and Hepatic Manifestations , Pages 415-425 , David S. Hallegua, Swamy Venuturupalli Chapter 34 - Hematologic and Lymphoid Abnormalities in SLE , Pages 426-437 , George A. Karpouzas Chapter 35 - Clinical and Epidemiologic Features of Lupus Nephritis , Pages 438-454 , Mary Anne Dooley Chapter 36 - Pregnancy in Women with SLE , Pages 455-463 , Megan E.B. Clowse Chapter 37 - Neonatal Lupus Erythematosus , Pages 464-472 , Marie Wahren-Herlenius, Sven-Erik Sonesson, Megan E.G. Clowse Chapter 38 - Reproductive and Hormonal Issues in Women with Autoimmune Diseases , Pages 473-483 , Eliza F. Chakravarty Chapter 39 - Drug-Induced Lupus: Etiology, Pathogenesis, and Clinical Aspects , Pages 484-494 , Dipak Patel, Bruce Richardson Chapter 40 - SLE in Childhood and Adolescence , Pages 495-505 , Thomas J.A. Lehman Chapter 41 - Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease , Pages 506-517 , Robert W. Hoffman, Eric L. Greidinger Chapter 42 - Clinical Aspects of the Antiphospholipid Syndrome , Pages 518-525 , Aisha Lateef, Michelle Petri Chapter 43 - Clinical Application of Serologic Tests, Serum Protein Abnormalities, and Other Clinical Laboratory Tests in SLE , Pages 526-540 , Francisco P. Quismorio Jr., Karina D. Torralba Chapter 44 - Differential Diagnosis and Disease Associations , Pages 541-554 , Meenakshi Jolly, Serene Francis, Winston Sequeira Chapter 45 - SLE and Infections , Pages 555-562.e1 , Judith A. James, Andrea L. Sestak, Evan S. Vista Chapter 46 - Clinical Measures, Metrics, and Indices , Pages 563-581 , Zahi Touma, Dafna D. Gladman, Murray B. Urowitz Chapter 47 - Principles of Therapy, Local Measures, and Nonsteroidal Medications , Pages 582-590 , Mariko Ishimori, Michael H. Weisman, Katy Setoodeh, Daniel J. Wallace Chapter 48 - Systemic Glucocorticoid Therapy in SLE , Pages 591-600 , Kyriakos A. Kirou, Dimitrios T. Boumpas Chapter 49 - Antimalarial Medications , Pages 601-608 , J. Antonio Aviña-Zubieta, John M. Esdaile Chapter 50 - Immunosuppressive Drug Therapy , Pages 609-625 , W. Joseph McCune, Tania Gonzalez-Rivera Chapter 51 - Specialized Treatment Approaches and Niche Therapies for Lupus Subsets , Pages 626-632.e12 , Daniel J. Wallace Chapter 52 - Adjunctive and Preventive Measures , Pages 633-639 , Diane L. Kamen Chapter 53 - Novel Therapies for SLE: Biological Agents Available in Practice Today , Pages 640-647 , Ronald F. van Vollenhoven Chapter 54 - Critical Issues in Drug Development for SLE , Pages 648-652 , Ronald F. van Vollenhoven Chapter 55 - Socioeconomic and Disability Aspects , Pages 653-658 , Michael M. Ward Chapter 56 - Investigational Agents and Future Therapy for SLE , Pages 659-665 , Georg H. Stummvoll, Josef S. Smolen Chapter 57 - Mortality in SLE , Pages 666-675 , Sasha Bernatsky, Deborah Levy, Rosalind Ramsey-Goldman, Caroline Gordon, Anisur Rahman, Ann E. Clarke Lupus Resource Materials , Pages 676-678 , Jenny Thorn Palter Historical Background of Discoid and SLE , Pages e1-e11 , Thomas G. Benedek Patient Guide to Lupus Erythematosus , Pages e12-e20 , Daniel J. Wallace, Bevra Hannahs Hahn, Francisco P. Quismorio Jr. Index , Pages 679-694 Index , Pages e21-e36 Section I: What Is Lupus? -- Chapter 1. Definition And Classification Of Lupus And Lupus-related Disorders / Jinoos Yazdany And Maria Dall'era -- Chapter 2. The Epidemiology Of Lupus / S. Sam Lim And Christina Drenkard -- Section Ii: The Pathogenesis Of Lupus -- Chapter 3. The Pathogenesis Of Sle / Bevra H. Hahn -- Chapter 4. Genetics Of Human Sle / Yun Deng And Betty P. Tsao -- Chapter 5. Epigenetics Of Lupus / Nan Shen, Dong Liang, Yuajia Tang, And Yuting Qin -- Chapter 6. The Innate Immune System In Sle / Lukas Bossaller And Ann Marshak-rothstein -- Chapter 7. Cytokines And Interferons In Lupus / Mary K. Crow, Timothy B. Niewold, And Kyriakos A. Kirou -- Chapter 8. The Structure And Derivation Of Antibodies And Autoantibodies / Giovanni Franchin, Yong-rui Zou, And Berry Diamond -- Chapter 9. T Cells / José C. Crispin And George C. Tsokos -- Chapter 10. Regulatory Cells In Sle / Antonio La Cava -- Chapter 11. Apoptosis, Necrosis, And Autophagy / Keith B. Elkon -- Chapter 12. Abnormalities In Immune Complex Clearance And Fcy Receptor Function / Jane E. Salmon And Robert P. Kimberly -- Chapter 13. Neural-immune Interactions: Principles And Relevance To Sle / Cherie L. Butts And Esther M. Sternberg -- Chapter 14. Complement And Sle / Chau-ching Liu, Susan Manzi, And Joseph M. Ahearn -- Chapter 15. Mechanisms Of Acute Inflammation And Vascular Injury In Sle / J. Michelle Kahlenberg And Mariana J. Kaplan -- Chapter 16. Mechanisms Of Tissue Damage-free Radicals And Fibrosis / Biji T. Kurien, Chandra Mohan, And R. Hal Scofield -- Chapter 17. Animal Models Of Sle / Bevra Hannahs Hahn And Dwight Kono -- Chapter 18. Pathogenetic Mechanisms In Lupus Nephritis / Anne Davidson, Celine Berthier, And Matthias Kretzler -- Section Iii: Autoantibodies -- Chapter 19. Immune Tolerance Defects In Lupus / Ram Raj Singh, Shweta Dubey, And Julia Pinkhasov -- Chapter 20. Autoantibodies / Edited By David Isenberg -- Antibody Structure, Function, And Production / Jessica Manson -- Antibodies To Dna, Histones, And Nucleosomes / Anisur Rahman, Jessica Manson, And David Isenberg -- Anti-lipoprotein And Anti-endothelial Cell Antibodies / Anisur Rahman -- Anti-c1q Antibodies / C. G. M. Kallenberg -- Antibodies Against The Extractable Nuclear Antigens Rnp, Sm, Ro/ssa, And La/ssb / Gabriela Riemekasten And Falk Hiepe -- Chapter 21. Autoantigenesis And Antigen-based Therapy And Vaccination In Sle / Ram Raj Singh, Julia Pinkhasov, Priti Prasad, And Shweta Dubey -- Section Iv: Clinical Aspects Of Sle -- Chapter 22. Overview And Clinical Presentation / Andrea Hinojosa-azaola And Jorge Sánchez-guerrero -- Chapter 23. Pathomechanisms Of Cutaneous Lupus Erythematosus / Jan P. Dutz -- Chapter 24. Skin Disease In Cutaneous Lupus Erythematosus / Benjamin F. Chong And Victoria P. Werth -- Chapter 25. The Musculoskeletal System And Bone Metabolism / Sandra V. Navarra And Tito P. Torralba -- Chapter 26. Pathogenesis And Treatment Of Atherosclerosis In Lupus / Maureen Mcmahon, Brian Skaggs, And Jennifer Grossman -- Chapter 27. Cardiopulmonary Disease In Sle / Guillermo Ruiz-irastorza And Munther Khamashta -- Chapter 28. Pathogenesis Of The Nervous Sytem / Cynthia Aranow, Betty Diamond, And Meggan Mackay -- Chapter 29. Clinical Aspects Of The Nervous System / Sterling G. West -- Chapter 30. Psychopathology, Neurodiagnostic Testing, And Imaging / John G. Hanly, Antonina Omisade, And John D. Fisk -- Chapter 31. Ocular, Aural, And Oral Manifestations / James T. Rosenbaum, Dennis R. Trune, Andre Barkhuizen, And Lyndell Lim -- Chapter 32. Management Of Sjödren Syndrome In Patients With Sle / Hendrika Bootsma, Hjalmar R. Bouma, Frans G. M. Kroese, Arjan Vissink, And Daniel J. Wallace -- Chapter 33. Gastrointestinal And Hepatic Manifestations / David S. Hallegua And Swamy Venuturupalli -- Chapter 34. Hematologic And Lymphoid Abnormalities In Sle / George A. Karpouzas -- Chapter 35. Clinical And Epidemiologic Features Of Lupus Nephritis / Mary Anne Dooley -- Section V: The Reproductive System And Hormones -- Chapter 36. Pregnancy In Women With Sle / Megan E. B. Clowse -- Chapter 37. Neonatal Lupus Erythematosus / Marie Wahren-herlenius, Sven-erik Sonesson, And Megan E. G. Clowse -- Chapter 38. Reproductive And Hormonal Issues In Women With Autoimmune Diseases / Eliza F. Chakravarty -- Section Vi: Special Considerations, Subsets Of Sle And Lupus-related Syndromes -- Chapter 39. Drug-induced Lupus: Etiology, Pathogenesis, And Clinical Aspects / Dipak Patel And Bruce Richardson -- Chapter 40. Sle In Childhood And Adolescence / Thomas J. A. Lehman -- Chapter 41. Mixed Connective Tissue Disease And Undifferentiated Connective Tissue Disease / Robert W. Hoffman And Eric L. Greidinger -- Chapter 42. Clinical Aspects Of The Antiphospholipid Syndrome / Aisha Lateef And Michelle Petri -- Section Vii: Assessment Of Lupus -- Chapter 43. Clinical Application Of Serologic Tests, Serum Protein Abnormalities, And Other Clinical Laboratory Tests In Sle / Francisco P. Quismorio, Jr., And Karina D. Torralba -- Chapter 44. Differential Diagnosis And Disease Associations / Meenakshi Jolly, Serene Francis, And Winston Sequeira -- Chapter 45. Sle And Infections / Judith A. James, Andrea L. Sestak, And Evan S. Vista -- Chapter 46. Clinical Measures, Metrics, And Indices / Zahi Touma, Dafna D. Gladman, And Murray B. Urowitz -- Section Viii: Managemen Of Sle -- Chapter 47. Principles Of Therapy, Local Measures, And Nonsteroidal Medications / Mariko Ishimori, Michael H. Weisman, Katy Setoodeh, And Daniel J. Wallace -- Chapter 48. Systemic Glucocorticoid Therapy In Sle / Kyriakos A. Kirou And Dimitrios T. Boumpas -- Chapter 49. Antimalarial Medications / J. Antonio Aviña-zubieta And John M. Esdaile -- Chapter 50. Immunosuppressive Drug Therapy / W. Joseph Mccune And Tania Gonzalez-rivera -- Chapter 51. Specialized Treatment Approaches And Niche Therapies For Lupus / Daniel J. Wallace -- Chapter 52. Adjunctive And Preventive Measures / Diane L. Kamen -- Chapter 53. Novel Therapies For Sle: Biological Agents Available In Practice Today / Ronald F. Van Vollenhoven -- Chapter 54. Critical Issues In Drug Development For Sle / Ronald F. Van Vollenhoven -- Chapter 55. Socioeconomic And Disability Aspects / Michael M. Ward -- Section Ix: Outcomes And Future Considerations -- Chapter 56. Investigational Agents And Future Therapy For Sle / Georg H. Stummvoll And Josef S. Smolen -- Chapter 57. Mortality In Sle / Sasha Bernatsky, Deborah Levy, Rosalind Ramsey-goldman, Caroline Gordon, Anisur Rahman, And Ann E. Clarke -- Appendix: Lupus Resource Materials / Jenny Thorn Palter. Edited By Daniel J Wallace, Bevra Hannahs Hahn ; Associate Editors, David Isenburg ... [et Al.]. Rev. Ed. Of: Dubois' Lupus Erythematosus / Editors, Daniel J. Wallace, Bevra Hannahs Hahn. 7th Ed. C2007. Includes Bibliographical References And Index. This book first published in 1966, for the past forty years, it has distinguished itself internationally as reference on lupus and related diseases. For rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on systemic lupus erythematosus (SLE) and related disorders, a complete arsenal of information on SLE, connective tissue diseases, and the antiphospholipid syndromes. Authoritative, comprehensive content that balances basic science with clinical expertise. Fundamental images of lupus rashes, graphs, algorithms, and copious drug dosing and differential diagnosis tables. Includes a patient's guide with glossary and a complication of resources for patients and health professionals. First time published in full color. 75% new contributors. 10 chapters new to this edition. Sleeker, trimmed-down text. Addition of Michael Weisman, Ronald Van Vollenhoven, Nan Shen, and David Isenberg as Associate editors Dubois' Lupus Erythematosus was first published in 1966. For the past forty years, the product has distinguished itself internationally as the go-to reference on lupus and related diseases For rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on systemic lupus erythematosus (SLE) and related disorders, this product delivers a complete arsenal of information on SLE, connective tissue diseases, and the antiphospholipid syndromes. Authoritative, comprehensive content that balances basic science with clinical expertise Fundamental images of lupus rashes, graphs, algorithms, and copious drug dosing and differential diagnosis tablesIncludes a patient's guide with glossary and a compliation of resources for patients and health professionals