Drugs and the Liver: High Risk Patients and Transplantation (Medical Science Symposia Series, 4)

In __Drugs and the Liver: High Risk patients and Transplantation__, leading physicians, hepatologists, pharmacologists, pathologists and transplant surgeons discuss the most recent advances in the field of liver disease and their treatment. Attention is focused on epidemiology, the diagnosis of disease (clinical chemistry, histopathology, medical imaging analysis), prognosis, prediction, and clinical management. Pathogenesis of diseases such as liver cirrhosis following viral disease or alcohol abuse are discussed at length, and special attention is dedicated to high risk patients (children, fulminant hepatitis). The other major topics include terminal liver failure, for which transplantation is now routine. The latter is discussed in depth, starting from the organ donor management, organ evaluation and preservation, new surgical techniques, post-transplant patient follow-up including side effects of immunosuppression, and reports of the latest drugs used to prevent rejection. Front Matter....Pages i-xxi Risk Assessment in Liver Transplantation Focus on Lung Function....Pages 1-9 Biochemical Basis Of Hepatic Ischemic/Reperfusion Injury....Pages 11-18 Donor Rating and Assessment of Pretransplant Prognosis by Use of the MEGX Test....Pages 19-24 Significance of Cyclosporine Pharmacokinetics in Liver Transplantation....Pages 25-30 Cyclosporin Toxicity and Liver Transplantation in High Risk Patients....Pages 31-32 Drug Treatment in Liver Transplanted Patients: Antihypertensive Therapy....Pages 33-41 Bacteremia After Liver Transplantation; Few Issues in Selection of Antibiotics for Treatment and Prophylaxis....Pages 43-47 Antiviral Drugs....Pages 49-54 The Use of Antiviral Drugs in Liver Transplant Patients....Pages 55-60 Drugs, Fetal Liver and Reproduction....Pages 61-66 Reproduction After Transplantation....Pages 67-73 Reproduction in Hbsag+ Liver Recipients Reproduction After Liver Transplantation for B-Virus Hepatitis....Pages 73-79 24 Hour-Hypothermic Preservation of Rat Liver with Euro-Collins and UW Solutions. Comparative Evaluation by 31P NMR Spectroscopy, Biochemical Assays and Light Microscopy....Pages 79-84 ATP Content During the Ischemic Period as an Indicator of Liver Viability. A Phosphorus-31 NMR Study....Pages 85-90 Drugs and Liver Disease....Pages 91-98 Liver Disease and Anticancer Drug Treatment....Pages 99-104 Pharmacokinetics of Anticancer Agents in Patients with Impaired Liver Function....Pages 105-111 Pathogenesis and Treatment of Alcoholic Liver Disease....Pages 113-119 Liver Fibrogenesis in Chronic Viral and Alcoholic Liver Disease....Pages 119-124 Hepatocellular Carcinoma....Pages 125-130 Treatment of Iron Dependent Chronic Liver Disease....Pages 131-136 Liver Transplantation for Chronic Liver Disease....Pages 137-142 Practical Uses of OKT3....Pages 143-148 Histopatology of Acute Liver Rejection (ALR) in OKT3 Treated Patients....Pages 149-154 Spin-Spin Relaxation Times as Viability Parameter of Liver Transplantation Grafts Investigation on a Pig Model....Pages 155-158 Urinary 6-ß Hydroxycortisol as a Predictor of Cyclosporine Blood Levels....Pages 159-163 Elucidation of the Metabolic Pathways of Cyclosporine in Vitro by Human Liver Microsomes....Pages 165-170 Fine-needle Aspiration Biopsy and Hepatotoxicity of Cyclosporin a in Orthotopic Liver Transplantation....Pages 171-176 Effect of FK 506 and Cyclosporins on Model Membranes Studied by Nuclear Magnetic Resonance Spectroscopy....Pages 177-184 Back Matter....Pages 185-187