Drug metabolism : current concepts : edited by Corina Ionescu, Mino R. Caira

Drug Metabolism: Current Concepts Corina Ionescu and Mino R Caira Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. The book includes chapters on ADME (drug absorption, distribution, metabolism and elimination) Pathways of biotransformation (Phase I and Phase II metabolic reactions) Enzymatic systems involved in biotransformation Induction and inhibition of drug-metabolising enzymes Factors that influence drug biotransformation The role of pharmacogenetics Drug-drug interactions and adverse reactions Strategies for drug design. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

drug Metabolism: Current Concepts Provides A Comprehensive Understanding Of The Processes That Take Place Following Ingestion Of A Medicinal Agent Or Xenobiotic, With An Emphasis On The Crucial Role Of Metabolism (biotransformation). How A Sound Knowledge Of These Phenomena Is Incorporated Into The Design Of Effective New Drug Candidates Is Also Explained. The User-friendly Text Focuses On Concepts Rather Than Extraneous Details And Is Supported By Many Illustrated Examples Of Biotransformations As Well As Frequent References To Current Critical Reviews And Articles Highlighting The Nature Of Research Objectives In This Vibrant Area Of Medicinal Development. The Final Topic On Strategies For Drug Design Relies On The Background Provided By The Rest Of The Book. This Book Is Ideally Suited As An Advanced Text For Courses In Drug Metabolism For Students Of Medicine, Pharmacy, Pharmacology, Biochemistry; And For Courses In Drug Design And Drug Delivery For Students Of Medicinal Chemistry. It Is Also Appropriate For Professional Seminars Or Courses That Relate To The Fate Of A Drug In The Body, Drug Interactions, Adverse Reactions And Drug Design.

Drug Metabolism in Context....Pages 1-40 Pathways of Biotransformation — Phase I Reactions....Pages 41-128 Pathways of Biotransformation — Phase II Reactions....Pages 129-170 Enzymatic Systems Involved in Drug Biotransformation....Pages 171-208 Induction and Inhibition of Drug-Metabolising Enzymes....Pages 209-242 Factors that Influence Drug Biotransformation....Pages 243-268 Impact of Gene Variability on Drug Metabolism....Pages 269-294 Drug Interactions and Adverse Reactions....Pages 295-368 Strategies for Drug Design....Pages 369-414 Provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). This book also explains how a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates