Drug Discovery and Design (Advances in Protein Chemistry, Vol 56) (Advances in Protein Chemistry)

Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of the topics covered include angiotensin converting enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal agents. Content: Preface Page xi Edward M. Scolnick “Natural history” clinical trials: An enduring contribution to modern medical practice Review Article Pages 1-12 Edward M. Scolnick, Eve E. Slater, George W. Williams Angiotensin-converting enzyme inhibitors Review Article Pages 13-75 Joel Menard, Arthur A. Patchett HMG-CoA reductase inhibitors Review Article Pages 77-114 D. Roger Illingworth, Jonathan A. Tobert Cyclooxygenase-2 inhibitors Review Article Pages 115-141 Alan S. Nies, Michael J. Gresser 5α-reductase inhibitors Review Article Pages 143-180 John D. McConnell, Elizabeth Stoner Peroxisome proliferator-activated receptor (PPAR)γ agonists for diabetes Review Article Pages 181-212 David E. Moller, Douglas A. Greene Discovery and clinical development of HIV-1 protease inhibitors Review Article Pages 213-251 Joel R. Huff, James Kahn Calcineurin inhibitors and the generalization of the presenting protein strategy Review Article Pages 253-291 Kurt W. Vogel, Roger Briesewitz, Thomas J. Wandless, Gerald R. Crabtree Pure selective estrogen receptor modulators, new molecules having absolute cell specificity ranging from pure antiestrogenic to complete estrogen-like activities Review Article Pages 293-368 Fernand Labrie, Claude Labrie, Alain Bélanger, Vincent Giguere, Jacques Simard, Yves Mérand, Sylvain Gauthier, Van Luu-The, Bernard Candas, Céline Martel, Shouqi Luo Monoclonal antibody therapy Review Article Pages 369-421 John W. Park, Josef Smolen Glucan synthase inhibitors as antifungal agents Review Article Pages 423-475 Myra B. Kurtz, John H. Rex Author index Pages 477-551 Subject index Pages 553-567 Examines research in the development of strategies to reduce medical uncertainty and build evidence. Some of the topics covered include angiotensin converting enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal agents.