توسعه دارو برای سرطان و دیابت: مسیری به سوی 2030

Key features include: Details the role of plants for the treatment and management of cancer and diabetes Discusses the role of phytocompounds as ligands for cancer and diabetic targets Reviews plants and the potential of phytochemicals as antidiabetic and anticancer drugs Explores the green biosynthesis of nanoparticles and their treatment efficiency Cover 1 Half Title 2 Title Page 4 Copyright Page 5 About the Editors 6 Contents 12 Contributors 16 Abbreviations 20 Foreword 26 Preface 28 PART I: CANCER AND LEADS FOR CANCER TREATMENT 32 1. Biomarkers for Screening of Premalignant Lesions and Therapeutic Surveillance 34 2. Kinase Targets in Cancer Drug Discovery 52 3. Essential Drug Properties and Stages in Anti-Cancer Drug Development 60 4. Plant Constituent as Anti-Cancer Drugs 74 5. Anticancer Properties of Some Effective Phytochemicals 90 6. Therapeutic Aspects of Some Extracts and Purified Cardiac Glycosides Obtained From Nerium oleander L 110 7. Challenging Compounds of Some Medicinal Plants Against Cancer 126 8. Medicinal Plants as Therapeutic Agents in the Treatment of Cancer 134 9. Cytotoxic, Apoptosis Inducing Effects and Anti-Cancerous Drug Candidature of Jasmonates 148 10. Apoptosis Activity of 1,2,-Benzene Dicarboxylic Acid Isolated from Andrographis paniculata on KB, SiHa and IMR Cancer Cell Line 160 11. Anticancer Drug Discovery From the Indian Spice Box 172 12. Phytochemical Investigation and Evaluation of Anti-Breast Cancer Activity of Chloroform Extract of Tagetes erecta 184 13. Isolation, Identification and In Silico Evaluation of Anticancer Activity of Flavone from Pisum sativum 198 14. Functional Lead Phytochemicals from the Rutaceae and Zingeiberaceae Plants for Development of Anticancer Drugs 208 15. In Vitro Anticancer Activity of Biophytum sensitivum on Liver Cancer Lines (HEPG2) 222 16. Saffron and Its Active Ingredients: A Natural Product with Potent Anticancer Property 230 PART II: ANTIDIABETIC DRUG DISCOVERY 248 17. Effects of Pterocarpus marsupium in the Management of Type 2 Diabetes Mellitus 250 18. Antidiabetic and Antihyperlipidemic Activities of Cyathea nilgiriensis (Holttum) on STZ Induced Diabetic Rats 264 19. Antidiabetic Activity of Drug Loaded Chitosan Nanoparticle 280 20. Antidiabetic Activity of Silver Nanoparticles Biosynthesized Using Ventilago maderaspatana Leaf Extract 294 21. Hypoglycemic Activity of Biophytum sensitivum Whole Plant Extracts on Alloxan Induced Diabetic Rat 306 22. Antidiabetic Activity of Ventilago maderaspatana Leaf Extracts on STZ Induced Diabetic Rats 314 23. Isolation, Identification, and Molecular Docking of Antidiabetic Compounds of Cyatheia nilgiriensis (Holttum) 324 24. Antidiabetic Potentials of Major Indian Spices: A Review 336 25. Aloe Species: Chemical Composition and Therapeutic Uses in Diabetic Treatment 374 Index 380 Kinase,Targets,in,Cancer,Drug,Discovery;,Plant,Constituent,as,Anti-Cancer,Drugs Kinase Targets in Cancer Drug Discovery,Plant Constituent as Anti-Cancer Drugs "Drug Development for Cancer and Diabetes: A Path to 2030 focuses on new developments in the discovery of drugs for the treatment of cancer and diabetes. This new book presents important recent advances, emerging trends, and novel innovations for these two world-leading diseases. It is structured in two parts. Part I consists of chapters that explores cancer cell cycle checkpoints, cancer biomarkers, essential drug properties, stages in anti-cancer drug development, and various bioactives that are effective against cancer. Part II presents a complete coverage of important advances and research discoveries in antidiabetic drugs. It details the potentials of medicinal plants and phytocompounds as sources for antidiabetic drugs and highlights the ethnobotanical basis of the compounds. With chapters written by professionals in the field of phytochemistry and pharmacology from key institutions around the world, this volume provides a wide coverage and will be useful especially for scientists in pharmaceutical field. Key features: presents novel discoveries and mechanisms for the treatment of cancer and diabetes, details the role of plants for the treatment and management of cancer and diabetes, discusses the role of phytocompounds as ligands for cancer and diabetic targets, reviews plants and the potential of phytochemicals as antidiabetic and anticancer drugs, explores the green biosynthesis of nanoparticles and their efficiency in the treatment of diabetes and cancer."-- Provided by publisher