Drug Design : Medicinal Chemistry: A Series of Monographs, Vol. 4

Drug Design, Volume IV covers the pharmaceutical phase of drug action, with emphasis on those aspects that are of importance in the design of optimally effective drug products. The book discusses biopharmaceutics as a basis for the design of drug products; the types and pharmacokinetics of peroral prolonged action dosage forms and parenteral prolonged action forms; and the design of topical drug products. The text also describes physical-chemical parameters which affect the bioavailability of topical drug products; the design of sunscreen preparations; as well as the clinical application of litholytic agents, which are preventive and curative drugs for nephrolithiasis. The design of biologically active nucleosides and of insecticidal chlorohydrocarbon derivatives is also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable. Content: MEDICINAL CHEMISTRY: A Series of Monographs , Page ii Front Matter , Page iii Copyright , Page iv List of Contributors , Page ix Preface , Pages xi-xii , E.J. ARIËNS Contents of Other Volumes , Pages xiii-xv Chapter 1 - Biopharmaceutics as a Basis for the Design of Drug Products , Pages 1-35 , Leslie Z. Benet Chapter 2 - Peroral Solid Dosage Forms with Prolonged Action , Pages 37-73 , W.A. Ritschel Chapter 3 - Parenteral Dosage Forms with Prolonged Action , Pages 75-92 , W.A. Ritschel Chapter 4 - Design of Topical Drug Products: Pharmaceutics , Pages 93-148 , Martin Katz Chapter 5 - Design of Topical Drug Products: Biopharmaceutics , Pages 149-192 , Boyd J. Poulsen Chapter 6 - The Design of Sunscreen Preparations , Pages 193-235 , Goswin W. van Ham, Wolfgang P. Herzog Chapter 7 - Litholytic Agents: Preventive and Curative Drugs for Nephrolithiasis , Pages 237-283 , George Kallistratos Chapter 8 - The Design of Biologically Active Nucleosides , Pages 285-378 , Alexander Bloch Chapter 9 - The Design of Insecticidal Chlorohydrocarbon Derivatives , Pages 379-444 , G.T. Brooks Author Index , Pages 445-469 Subject Index , Pages 471-489