Drug Design : Medicinal Chemistry: A Series of Monographs, Vol. 3

Drug Design, Volume III covers the mode of action of biologically active compounds. The book discusses microbial transformations that have been used in the preparation of drugs or closely related substances; the use of linear free energy parameters and other experimental constants in structure-activity studies; and the mode of action of anticoagulants structurally and functionally related to vitamin K. The text also describes the design of beta-blocking drugs, biologically active acridines, local anesthetics, and insect chemosterilants. The molecular approach for designing inhibitors to enzymes involved in blood clotting is also considered. Chemists, pharmacologists, and people involved in drug design. Content: MEDICINAL CHEMISTRY: A Series of Monographs , Page ii Front Matter , Page iii Copyright , Page iv List of Contributors , Pages ix-x Preface , Page xi , E.J. ARIËNS Contents of Other Volumes , Pages xiii-xv Chapter 1 - Microbial Conversion as a Tool in the Preparation of Drugs , Pages 1-131 , R. Beukers, A.F. Marx, M.H.J. Zuidweg Chapter 2 - The Use of Linear Free Energy Parameters and Other Experimental Constants in Structure–Activity Studies , Pages 133-187 , A. Verloop Chapter 3 - Anticoagulants Structurally and Functionally Related to Vitamin K , Pages 189-203 , T. Kralt, V. Claassen Chapter 4 - Design of β-Blocking Drugs , Pages 205-228 , A.M. Barrett Chapter 5 - The Design of Biologically Active Acridines , Pages 229-242 , Adrien Albert Chapter 6 - The Design of Local Anesthetics , Pages 243-391 , J. Büchi, X. Perlia Chapter 7 - Design of Insect Chemosterilants , Pages 393-413 , Ralph B. Turner Chapter 8 - Molecular Approach for Designing Inhibitors to Enzymes Involved in Blood Clotting , Pages 415-447 , L. Lorandand, J.L.G. Nilsson Author Index , Pages 449-473 Subject Index , Pages 475-502