Drug Delivery in Oncology: From Basic Research to Cancer Therapy 3 vols.

In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy. In This First Authoritative Overview On Modern Cancer Chemotherapy 121 International Specialists Have Contributed Their Experience And Recent Data For What Is Likely To Become The Gold Standard In The Field. The Authors Summarize Knowledge Gained Over The Past Decade, From Basic Concepts To Successful Applications In The Clinic, Covering Active And Passive Targeting Strategies As Well As Tissue-specific Approaches. All Current And Future Targeted Delivery Systems Are Discussed, From Ligand-based To Antibody-based Polymer-based Systems, Right Up To Micro- And Nanoparticulate Systems. A. Front Matter -- Principles Of Tumor Targeting. Limits Of Conventional Cancer Chemotherapy / Klaus Mross, Felix Kratz -- Pathophysiological And Vascular Characteristics Of Solid Tumors In Relation To Drug Delivery / Peter Vaupel -- Enhanced Permeability And Retention Effect In Relation To Tumor Targeting / Hiroshi Maeda -- Pharmacokinetics Of Immunoglobulin G And Serum Albumin: Impact Of The Neonatal Fc Receptor On Drug Design / Jan Terje Andersen, Inger Sandlie -- Development Of Cancer-targeting Ligands And Ligand-drug Conjugates / Ruiwu Liu, Kai Xiao, Juntao Luo, Kit S Lam -- Antibody-directed Enzyme Prodrug Therapy (adept) - Basic Principles And Its Practice So Far / Kenneth D Bagshawe -- Tumor Imaging. Imaging Techniques In Drug Development And Clinical Practice / John C Chang, Sanjiv S Gambhir, Jurgen K Willmann -- Magnetic Nanoparticles In Magnetic Resonance Imaging And Drug Delivery / Patrick D Sutphin, Efřn J Flores, Mukesh Harisinghani --^ Preclinical And Clinical Tumor Imaging With Spect/ct And Pet/ct / Andreas K Buck, Florian G̃rtner, Ambros Beer, Ken Herrmann, Sibylle Ziegler, Markus Schwaiger -- Macromolecular Drug Delivery Systems. Empowered Antibodies For Cancer Therapy / Stephen C Alley, Simone Jeger, Robert P Lyon, Django Sussman, Peter D Senter -- Mapping Accessible Vascular Targets To Penetrate Organs And Solid Tumors / Kerri A Massey, Jan E Schnitzer -- Considerations Of Linker Technologies / Laurent Ducry -- Antibody-maytansinoid Conjugates: From The Bench To The Clinic / Hans Erickson -- Calicheamicin Antibody-drug Conjugates And Beyond / Puja Sapra, John Dijoseph, Hans-peter Gerber -- Antibodies For The Delivery Of Radionuclides / Anna M Wu -- Bispecific Antibodies And Immune Therapy Targeting / Sergej M Kiprijanov -- Design Of Polymer-drug Conjugates / Jindrich Kopecek, Pavla Kopeckov̀ --^ Dendritic Polymers In Oncology: Facts, Features, And Applications / Mohiuddin Abdul Quadir, Marcelo Calder̤n, Rainer Haag -- Site-specific Prodrug Activation And The Concept Of Self-immolation / Andř Warnecke -- Ligand-assisted Vascular Targeting Of Polymer Therapeutics / Anat Eldar-boock, Dina Polyak, Ronit Satchi-fainaro -- Drug Conjugates With Poly(ethylene Glycol) / Hong Zhao, Lee M Greenberger, Ivan D Horak -- Thermo-responsive Polymers / Drazen Raucher, Shama Moktan -- Polysaccharide-based Drug Conjugates For Tumor Targeting / Gurusamy Saravanakumar, Jae Hyung Park, Kwangmeyung Kim, Ick Chan Kwon -- Serum Proteins As Drug Carriers Of Anticancer Agents / Felix Kratz, Andreas Wunder, Bakheet Elsadek -- Future Trends, Challenges, And Opportunities With Polymer-based Combination Therapy In Cancer / Coralie Deladriere, Rut Lucas, Mar̕a J Vicent -- Clinical Experience With Drug-polymer Conjugates / Khalid Abu Ajaj, Felix Kratz --^ Nano- And Microparticulate Drug Delivery Systems. Overview On Nanocarriers As Delivery Systems / Haifa Shen, Elvin Blanco, Biana Godin, Rita E Serda, Agathe K Streiff, Mauro Ferrari -- Development Of Pegylated Liposomes / I Craig Henderson -- Immunoliposomes / Vladimir P Torchilin -- Responsive Liposomes (for Solid Tumor Therapy) / Stavroula Sofou -- Nanoscale Delivery Systems For Combination Chemotherapy / Barry D Liboiron, Paul G Tardi, Troy O Harasym, Lawrence D Mayer -- Micellar Structures As Drug Delivery Systems / Nobuhiro Nishiyama, Horacio Cabral, Kazunori Kataoka -- Tailor-made Hydrogels For Tumor Delivery / Sungwon Kim, Kinam Park -- Ph-triggered Micelles For Tumor Delivery / Haiqing Yin, You Han Bae -- Albumin-drug Nanoparticles / Neil Desai -- Carbon Nanotubes / David A Scheinberg, Carlos H Villa, Freddy Escorcia, Michael R Mcdevitt -- Ligand-based Drug Delivery Systems. Cell-penetrating Peptides In Cancer Targeting / Kaido Kurrikoff, Julia Suhorut, Lo Langel --^ Targeting To Peptide Receptors / Andrew V Schally, Gabor Halmos -- Aptamer Conjugates: Emerging Delivery Platforms For Targeted Cancer Therapy / Zeyu Xiao, Jillian Frieder, Benjamin A Teply, Omid C Farokhzad -- Design And Synthesis Of Drug Conjugates Of Vitamins And Growth Factors / Iontcho R Vlahov, Paul J Kleindl, Fei You -- Drug Conjugates With Polyunsaturated Fatty Acids / Joshua Seitz, Iwao Ojima -- Special Topics. Rna Drug Delivery Approaches / Yuan Zhang, Leaf Huang -- Local Gene Delivery For Therapy Of Solid Tumors / Wolfgang Walther, Peter M Schlag, Ulrike Stein -- Viral Vectors For Rna Interference Applications In Cancer Research And Therapy / Henry Fechner, Jens Kurreck -- Design Of Targeted Protein Toxins / Hendrik Fuchs, Christopher Bachran -- Drug Targeting To The Central Nervous System / Gert Fricker, Anne Mahringer, Melanie Ott, Valeska Reichel -- Liver Tumor Targeting / Katrin Hochḏrffer, Giuseppina Di Stefano, Hiroshi Maeda, Felix Kratz --^ Photodynamic Therapy: Photosensitizer Targeting And Delivery / Pawel Mroz, Sulbha K Sharma, Timur Zhiyentayev, Ying-ying Huang, Michael R Hamblin -- Tumor-targeting Strategies With Anticancer Platinum Complexes / Markus Galanski, Bernhard K Keppler -- Index. Edited By Felix Kratz, Peter Senter, And Henning Steinhagen. Includes Bibliographical References And Index. Volume 1: PRINCIPLES OF TUMOR TARGETING Limits of Conventional Cancer Chemotherapy Pathophysiological and Vascular Characteristics of Tumors in Relation to Drug Delivery Enhanced Permeability and Retention Effect in Relation to Tumor Targeting Pharmacokinetics of Immunoglobulin G and Serum Albumin: Impact of the Neonatal Fc Receptor on Drug Design Development of Cancer-Targeting Ligands and Ligand-Drug Conjugates Antibody-Directed Enzyme Prodrug Therapy (ADEPT) - Basic Principles and its Practice So Far TUMOR IMAGING Imaging Techniques in Drug Development and Clinical Practice Magnetic Nanoparticles in Magnetic Resonance Imaging and Drug Delivery Preclinical and Clinical Tumor Imaging with SPECT/CT and PET/CT Volume 2: MACROMOLECULAR DRUG DELIVERY SYSTEMS Antibody-Based Systems Empowered Antibodies for Cancer Therapy Mapping Accessible Vascular Targeting to Penetrate Organs and Solid Tumors Considerations of Linker Technologies Antibody-Maytansinoid Conjugates: From the Bench to the Clinic Calicheamicin Antibody-Drug Conjugates and Beyond Antibodies for the Delivery of Radionuclides Bispecific Antibodies and Immune Therapy Targeting POLYMER-BASED SYSTEMS Design of Polymer-Drug Conjugates Dendritic Polymers in Oncology: Facts, Features, and Applications Site-Specific Prodrug Activation and the Concept of Self-Immolation Ligand-Assisted Vascular Targeting of Polymer Therapeutics Drug Conjugates with Poly(Ethylene)Glycole Thermo-Responsive Polymers Polysaccharide-Based Drug Conjugates for Tumor Targeting Serum Proteins as Drug Carriers of Anticancer Agents Future Trends, Challenges, and Opportunities with Polymer-Based Combination Therapy in Cancer Clinical Experience with Drug-Polymer Conjugates NANO- AND MICROPARTICULATE DRUG DELIVERY SYSTEMS - LIPID-BASED SYSTEMS Overview on Nanocarriers as Delivery Systems Development of PEGylated Liposomes Immunoliposomes Responsive Liposomes (for Solid Tumor Therapy) Nanoscale Delivery Systems for Combination Chemotherapy NANO- AND MICROPARTICULATE DRUG DELIVERY SYSTEMS - POLYMER-BASED SYSTEMS Micellar Strcutures as Drug Delivery Systems Tailor-Made Hydrogels for Tumor Delivery pH-Triggered Micelles for Tumor Delivery Albumin-Drug Nanoparticles Carbon Nanotubes Volume 3: LIGAND-BASED DRUG DELIVERY SYSTEMS Cell-Penetrating Peptides in Cancer Targeting Targeting to Peptide Receptors Aptamer Conjugates: Emerging Delivery Platforms for Targeted Cancer Therapy Design and Synthesis of Drug Conjugates of Vitamins and Growth Factors Drug Conjugates with Polyunsaturated Fatty Acids SPECIAL TOPICS RNA Drug Delivery Approaches Local Gene Delivery for Therapy of Solid Tumors Viral Vectors for RNA Interference Applications in Cancer Research and Therapy Design of Targeted Protein Toxins Drug Targeting to the Central Nervous System Liver Tumor Targeting Photodynamic Therapy: Photosensitizers Targeting and Delivery Tumor-Targeting Strategies with Anticancer Platinum Complexes