Drosophila Models for Human Diseases (Advances in Experimental Medicine and Biology, 1076)

"Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila's value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases"--Publisher's description Front Matter ....Pages i-x Drosophila as a Model Organism (Masamitsu Yamaguchi, Hideki Yoshida)....Pages 1-10 Adult Intestine Aging Model (Koji Takeda, Takashi Okumura, Kiichiro Taniguchi, Takashi Adachi-Yamada)....Pages 11-23 Alzheimer’s Disease Model System Using Drosophila (Leo Tsuda, Young-Mi Lim)....Pages 25-40 Parkinson’s Disease Model (Vuu My Dung, Dang Thi Phuong Thao)....Pages 41-61 Repeat Expansion Disease Models (Morio Ueyama, Yoshitaka Nagai)....Pages 63-78 Amyotrophic Lateral Sclerosis Model (Yumiko Azuma, Ikuko Mizuta, Takahiko Tokuda, Toshiki Mizuno)....Pages 79-95 Drosophila Charcot-Marie-Tooth Disease Models (Masamitsu Yamaguchi, Hiroshi Takashima)....Pages 97-117 Drosophila as a Model to Gain Insight into the Role of lncRNAs in Neurological Disorders (Luca Lo Piccolo)....Pages 119-146 Muscular Dystrophy Model (Saranyapin Potikanond, Wutigri Nimlamool, Jasprien Noordermeer, Lee G. Fradkin)....Pages 147-172 Drosophila As a Cancer Model (Masato Enomoto, Carmen Siow, Tatsushi Igaki)....Pages 173-194 From Drosophila Blood Cells to Human Leukemia (Manon Boulet, Marion Miller, Laurence Vandel, Lucas Waltzer)....Pages 195-214 Diseases Associated with Mutation of Replication and Repair Proteins (Sue Cotterill)....Pages 215-234 Drosophila Models to Investigate Insulin Action and Mechanisms Underlying Human Diabetes Mellitus (Yoshihiro H. Inoue, Hiroka Katsube, Yukiko Hinami)....Pages 235-256 Metabolomics: State-of-the-Art Technologies and Applications on Drosophila melanogaster (Phan Nguyen Thuy An, Eiichiro Fukusaki)....Pages 257-276 Humanized Flies and Resources for Cross-Species Study (Toshiyuki Takano-Shimizu-Kouno, Takashi Ohsako)....Pages 277-288 Designs for Flies + of Mice and Men: Design Approaches to Drosophila melanogaster (Julia Cassim, Frank Kolkman, Marcel Helmer)....Pages 289-305 Back Matter ....Pages 307-308