DNA REPLICATION - CURRENT ADVANCES

The Study Of Dna Advanced Human Knowledge In A Way Comparable To The Major Theories In Physics, Surpassed Only By Discoveries Such As Fire Or The Number Zero. However, It Also Created Conceptual Shortcuts, Beliefs And Misunderstandings That Obscure The Natural Phenomena, Hindering Its Better Understanding. The Deep Conviction That No Human Knowledge Is Perfect, But Only Perfectible, Should Function As A Fair Safeguard Against Scientific Dogmatism And Enable Open Discussion. With This Aim, This Book Will Offer To Its Readers 30 Chapters On Current Trends In The Field Of Dna Replication. As Several Contributions In This Book Show, The Study Of Dna Will Continue For A While To Be A Leading Front Of Scientific Activities. preface_ DNA Replication-Current Advances......Page 1 Part 1......Page 15 01_DNA Structure: Alphabet Soup for the Cellular Soul......Page 17 02_Replication Demands an Amendment of the Double Helix......Page 43 03_Phosphorothioation: An Unusual Post-Replicative Modification on the DNA Backbone......Page 71 04_Mitosis and DNA Replication and Life Origination Hydrate Hypotheses: Common Physical and Chemical Grounds......Page 89 Part 2......Page 129 05_Strand-specific Composition Bias in Bacterial Genomes......Page 131 06_Mutation Patterns Due to Converging Mitochondrial Replication and Transcription Increase Lifespan, and Cause Growth Rate-Longevity Tradeoffs......Page 151 07_Mitochondrial DNA Replication in Health and Disease......Page 181 08_Damage and Replication Stress Responses......Page 197 Part 3......Page 215 09_Relationship between Fork Progression and Initiation of Chromosome Replication in E. coli......Page 217 10_Replication Origin Selection and Pre-Replication Complex Assembly......Page 235 11_The Coordination between DNA Replication Initiation and Other Cell Cycle Events......Page 247 12_The Organisation of Replisomes......Page 267 13_Eukaryotic Replication Barriers: How, Why and Where Forks Stall......Page 283 14_Control of Telomeric DNA Replication: Genetics, Molecular Biology, and Physiology......Page 319 15_Telomere Maintenance in Organisms without Telomerase......Page 337 16_Eukaryote DNA Replication and Recombination: an Intimate Association......Page 361 Part 4......Page 403 17_Cell Cycle Regulation of DNA Replication in S. cerevisiae......Page 405 18_Free Histones and the Cell Cycle......Page 423 19_Involvement of Linker Histones in the Regulation of Replication Timing......Page 441 20_Replication Timing: Evolution, Nuclear Organization and Relevance for Human Disease......Page 451 21_The Silencing Face of DNA Replication: Gene Repression Mediated by DNA Replication Factors......Page 481 Part 5......Page 499 22_Faithful DNA Replication Requires Regulation of CDK Activity by Checkpoint Kinases......Page 501 23_Regulation of the G1/S Transition in Adult Liver: Expression and Activation of the Cyclin Dependent Kinase Cdk1 in Differentiated Hepatocytes is Controlled by Extracellular Signals and is Crucial for Commitment to DNA Replication......Page 525 24_Binding of Human MCM-BP with MCM2-7 Proteins......Page 563 25_DNA Replication in Animal Systems Lacking Thioredoxin Reductase I......Page 579 Part 6......Page 599 26_Prevalence of Reactivation of Hepatitis B Virus DNA Replication in Rheumatoid Arthritis Patients......Page 601 27_Oncogenic Aspects of HPV Infections of the Female Genital Tract......Page 609 28_The Role of E2 Proteins in Papillomavirus DNA Replication......Page 627 29_Topoisomerase I and II Expression in Recurrent Colorectal Cancer Cells: A Dubious Matter......Page 653 30_Bacterial Genetics of Large Mammalian DNA Viruses: Bacterial Artificial Chromosomes as a Prerequisite for Efficiently Studying Viral DNA Replication and Functions......Page 683