DNA Repair and Replication (Volume 69) (Advances in Protein Chemistry, Volume 69)

DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters. Selected Contents: -Base Excision Repair -Eukaryotic DNA Mismatch Repair -Double Strand Break Repair -Functions of DNA Polymerases -Somatic Hypermutation: A Mutational Panacea Content: Preface Pages ix-xi Base Excision Repair Original Research Article Pages 1-41 J.Christopher Fromme, Gregory L. Verdine Nucleotide Excision Repair in E. Coli and Man Original Research Article Pages 43-71 Aziz Sancar, Joyce T. Reardon Photolyase and Cryptochrome Blue-Light Photoreceptors Original Research Article Pages 73-100 Aziz Sancar Coordination of Repair, Checkpoint, and Cell Death Responses to DNA Damage Original Research Article Pages 101-135 Jean Y.J. Wang, Sarah K. Cho Functions of DNA Polymerases Original Research Article Pages 137-165 Katarzyna Bebenek, Thomas A. Kunkel Cellular Functions of DNA Polymerase ζ and Rev1 Protein Original Research Article Pages 167-203 Christopher W. Lawrence DNA Polymerases η and ι Original Research Article Pages 205-228 Alexandra Vaisman, Alan R. Lehmann, Roger Woodgate Properties and Functions of Escherichia Coli : Pol IV and Pol V Original Research Article Pages 229-264 Robert P. Fuchs, Shingo Fujii, Jérôme Wagner Mammalian Pol κ: Regulation of its Expression and Lesion Substrates Original Research Article Pages 265-278 Haruo Ohmori, Eiji Ohashi, Tomoo Ogi DNA Postreplication Repair Modulated by Ubiquitination and Sumoylation Original Research Article Pages 279-306 Landon Pastushok, Wei Xiao Somatic Hypermutation: A Mutational Panacea Original Research Article Pages 307-335 Brigette Tippin, Phuong Pham, Ronda Bransteitter, Myron F. Goodman Author Index Pages 337-367 Subject Index Pages 369-384 DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters. Selected Contents: -Base Excision Repair-Eukaryotic DNA Mismatch Repair-Double Strand Break Repair-Functions of DNA Polymerases-Somatic Hypermutation: A Mutational Panacea When Marshall McLuhan coined the phrase "the medium is the message," he could not have imagined just how perfectly his shrewd commentary on pop culture would summarize the entire molecular underpinnings of genetics.