تغییرات DNA در مغز: تنظیم نورواپیژنتیکی بیان ژن

__DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression__ begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease. Front Cover -- DNA MODIFICATIONSIN THE BRAIN -- DNA MODIFICATIONSIN THE BRAIN: Neuroepigenetic Regulation of Gene Expression -- Copyright -- CONTENTS -- LIST OF CONTRIBUTORS -- PREFACE -- 1 - History and Modern View on DNA Modifications in the Brain -- INTRODUCTION -- DNA METHYLATION AND ITS INFLUENCE ON DNA STRUCTURE AND INTERACTION WITH PROTEINS -- REPLICATIVE DNA METHYLATION AND THE INHERITANCE OF THE DNA METHYLATION PATTERN -- DNA METHYLTRANSFERASES -- DNA DEMETHYLATION -- SPECIFICITY OF DNA METHYLATION -- FUNCTIONAL ROLES OF DNA METHYLATION -- Species, tissue, and age specificity -- Gene expression -- Learning and memory -- Early life stress behavior -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- 2 - Approaches to Detecting DNA Base Modification in the Brain -- METHODS FOR DETECTION OF DNA MODIFICATIONS IN THE GENOME -- Chromatography and mass spectrometry -- Southern blot -- BISULFITE SEQUENCING FOR THE DETECTION OF 5MC -- ANALYSIS OF BISULFITE-TREATED DNA WITHOUT SEQUENCING -- EXTENDING BISULFITE SEQUENCING: BEYOND 5MC -- RESTRICTION ENZYMES FOR DNA MODIFICATIONS -- DNA IMMUNOPRECIPITATION -- OTHER CHEMICAL APPROACHES -- SUMMARY -- DETECTION OF DNA MODIFICATIONS IN THE BRAIN -- CANDIDATE GENE APPROACH -- MICROARRAY SCREENING -- GENOME-WIDE SEQUENCING APPROACHES -- CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- 3 - Active DNA Demethylation in Neurodevelopment -- INTRODUCTION -- FUNDAMENTAL BRAIN DEVELOPMENT -- INTERPLAY OF DNA METHYLATION AND DEMETHYLATION -- DNA methyltransferase -- Ten-eleven translocation cytosine dioxygenase -- Thymine DNA glycosylase -- MAPPING AND QUANTIFICATION OF THE DERIVATIVES OF 5MC -- DISCUSSION -- REFERENCES -- 4 - TET and 5hmC in Neurodevelopment and the Adult Brain -- INTRODUCTION -- GLOBAL 5HMC AND TET EXPRESSION THROUGHOUT THE ADULT BRAIN -- GENOMIC DISTRIBUTION OF 5HMC

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states.

Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.

• Provides a comprehensive overview of the many facets of DNA modifications
• Discusses the impact of this dynamic epigenetic mechanism across brain development and lifespan at behavioral, cognitive, molecular and genetic levels
• Contains contributions by influential leaders in the field
• Edited by a Neuroscientist to further promote synthesis between epigenetics, neuroscience, and clinical relevance

Content: Front Matter,Copyright,List of Contributors,PrefaceEntitled to full textChapter 1 - History and Modern View on DNA Modifications in the Brain, Pages 1-25, B.F. Vanyushin, V.V. Ashapkin Chapter 2 - Approaches to Detecting DNA Base Modification in the Brain, Pages 27-41, X. Li, W. Wei Chapter 3 - Active DNA Demethylation in Neurodevelopment, Pages 43-59, Y. Kang, Z. Wang, P. Jin Chapter 4 - TET and 5hmC in Neurodevelopment and the Adult Brain, Pages 61-79, M. Fasolino, S.A. Welsh, Z. Zhou Chapter 5 - Beyond mCG: DNA Methylation in Noncanonical Sequence Context, Pages 81-94, E.A. Mukamel, R. Lister Chapter 6 - DNA Modifications and Memory, Pages 95-111, J.J. Day Chapter 7 - Measuring CpG Methylation by SMRT Sequencing, Pages 113-125, Y. Suzuki, J. Korlach, S. Morishita Chapter 8 - Epigenetic Modifications of DNA and Drug Addiction, Pages 127-147, J. Feng, E.J. Nestler Chapter 9 - What Does the Future Hold for the Study of Nucleic Acid Modifications in the Brain?, Pages 149-159, P.R. Marshall, T.W. Bredy Index, Pages 161-167 Begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.-- Source other than the Library of Congress Edited By Timothy W. Bredy. Mode Of Access: World Wide Web.