DNA Damage and Repair: Volume 2: DNA Repair in Higher Eukaryotes (Contemporary Cancer Research)

DNA Damage and Repair offers a critical, cutting-edge review of all major aspects of DNA repair in a wide variety of organisms, including every important model system. Volume II: DNA Repair in Higher Eukaryotes focuses mammalian systems and human genetic disease and cancer, emphasizing the significant progress that has been made in the past five years. Written by award-winning researchers at the forefront of their fields, each chapter has undergone a rigorous peer-review cycle to ensure definitive and comprehensive treatment of its topic. Extensive up-to-date references, along with clear figures illustrating complex relationships between DNA repair and other DNA dynamic processes and cell functions, bring this volume to the active frontiers of research. Major topics include UV and X-ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. A complementary volume, Volume I: DNA Repair in Prokaryotes and Lower Eukaryotes , focuses on DNA damage and repair in prokaryotic and model eukaryotic systems. This major new treatise provides the reader with up-to-date critical surveys of every important area of research on DNA damage and the repair mechanisms in each major system currently under investigation. Authoritative and timely, DNA Damage and Repair is certain to become the new standard reference and resource in the field. Front Matter....Pages i-xiii Overview....Pages 1-8 DNA Photolyases....Pages 9-32 Cellular Responses to Methylation Damage....Pages 33-49 Exogenous Carcinogen-DNA Adducts and Their Repair in Mammalian Cells....Pages 51-64 Nature of Lesions Formed by Ionizing Radiation....Pages 65-84 Mammalian Enzymes for Preventing Mutations Caused by Oxidation of Guanine Nucleotides....Pages 85-93 Biochemistry of Mammalian DNA Mismatch Repair....Pages 95-118 Short Patch Mismatch Repair in Mammalian Cells....Pages 119-131 Role of HMG and Other Proteins in Recognition of Cisplatin DNA Damage....Pages 133-141 TFIIH....Pages 143-159 Mammalian DNA Repair and the Cellular DNA Polymerases....Pages 161-180 Cellular Functions of Mammalian DNA Ligases....Pages 181-198 Modulations in Chromatin Structure During DNA Damage Formation and DNA Repair....Pages 199-222 Transcriptional Responses to Damage Created by Ionizing Radiation....Pages 223-262 Posttranslational Mechanisms Leading to Mammalian Gene Activation in Response to Genotoxic Stress....Pages 263-298 Mechanisms for DNA Double-Strand Break Repair in Eukaryotes....Pages 299-316 Mutant Rodent Cells Defective in DNA Double-Strand Break Repair....Pages 317-334 Nucleotide Excision Repair....Pages 335-393 Cellular Responses to DNA Damage and Human Chromosome Instability Syndromes....Pages 395-442 Genetics of DNA Mismatch Repair, Microsatellite Instability, and Cancer....Pages 443-464 Mammalian Cell-Cycle Responses to DNA-Damaging Agents....Pages 465-486 Poly(ADP-Ribose) Polymerase in Response to DNA Damage....Pages 487-515 DNA Topoisomerases in DNA Repair and DNA Damage Tolerance....Pages 517-537 Molecular Approaches for Detecting DNA Damage....Pages 539-557 Radiation-Induced Damage and the Formation of Chromosomal Aberrations....Pages 559-585 Whole-Organism Responses to DNA Damage....Pages 587-601 DNA Damage and Repair in the Clinic....Pages 603-625 Back Matter....Pages 627-639 Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.