Dj-1/park7 Protein: Parkinson’s Disease, Cancer And Oxidative Stress-induced Diseases (advances In Experimental Medicine And Biology)

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The __DJ-1__ gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The __DJ-1__ gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of __DJ-1__, and explains the history and research development to understand the following chapters. Those chapters present the roles of __DJ-1__ in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. Front Matter ....Pages i-viii Introduction/Overview (Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga)....Pages 1-4 Structural Biology of the DJ-1 Superfamily (Nathan Smith, Mark A. Wilson)....Pages 5-24 Expression of DJ-1 in Neurodegenerative Disorders (Daria Antipova, Rina Bandopadhyay)....Pages 25-43 Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance (Takahiko Kawate, Benio Tsuchiya, Keiichi Iwaya)....Pages 45-59 Role of DJ-1 in Fertilization (An Chunna, Xiao-Ping Pu)....Pages 61-66 The Multifaceted Roles of DJ-1 as an Antioxidant (Prahlad V. Raninga, Giovanna Di Trapani, Kathryn F. Tonissen)....Pages 67-87 Transcriptional Regulation of DJ-1 (Kazuko Takahashi-Niki, Takeshi Niki, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga)....Pages 89-95 Regulation of Signal Transduction by DJ-1 (Stephanie E. Oh, M. Maral Mouradian)....Pages 97-131 Protein Repair from Glycation by Glyoxals by the DJ-1 Family Maillard Deglycases (Mouadh Mihoub, Jad Abdallah, Gilbert Richarme)....Pages 133-147 DJ-1 as a Biomarker of Parkinson’s Disease (Yoshiro Saito)....Pages 149-171 The Role of the Antioxidant Protein DJ-1 in Type 2 Diabetes Mellitus (Daniel Eberhard, Eckhard Lammert)....Pages 173-186 Therapeutic Activities of DJ-1 and Its Binding Compounds Against Neurodegenerative Diseases (Masatoshi Inden, Daijiro Yanagisawa, Masanori Hijioka, Hiroyoshi Ariga, Yoshihisa Kitamura)....Pages 187-202 DJ-1 as a Therapeutic Target Against Cancer (Ji Cao, Xiaobing Chen, Meidan Ying, Qiaojun He, Bo Yang)....Pages 203-222 Annotation This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson's disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases