Diverse Effects of Hypoxia on Tumor Progression (Current Topics in Microbiology and Immunology Book 345)

Solid tumors frequently contain areas of oxygen deprivation (hypoxia) due to rapid cell proliferation and/or vascular insufficiency. The presence of hypoxic domains typically correlates with poor patient prognosis, due to the relative resistance of hypoxic cells to conventional cancer therapies and effects of O2 availability on disease progression. The response of malignant cells to hypoxia has been the focus of intense research over the last decade. In this issue of Current Topics in Microbiology and Immunology, the authors present articles describing the impact of hypoxia on components of the tumor microenvironment (such as endothelial cells, inflammatory cells, and tumor associated fibroblasts), the expression of unique microRNAs, tumor cell differentiation status, and metastasis. Each review article describes the state of the field studying these topics, and poses important questions for the future. The overall goal is to depict tumor phenotypes and associated molecular pathways to be exploited in the development of novel therapeutics to be used against a broad spectrum of human cancers. The Hif-2[alpha]-driven Pseudo-hypoxic Phenotype In Tumor Aggressiveness, Differentiation, And Vascularization / A. Pietras, A.s. Johnsson And S. Pahlman -- Hypoxia And Hypoxia Inducible Factors In Cancer Stem Cell Maintenance / Z. Li And J.n. Rich -- Role Of Carcinoma-associated Fibroblasts And Hypoxia In Tumor Progression / A.j. Giaccia And E. Schipani -- The Role Of Hypoxia Regulated Micrornas In Cancer / R. Mccormick ... [et Al.] -- Oxygen Sensing: A Common Crossroad In Cancer And Neurodegeneration / A. Quaegebeur And P. Carmeliet -- Hypoxia-inducible Factors As Essential Regulators Of Inflammation / H.z. Imtiyaz And M.c. Simon -- Hypoxia And Metastasis In Breast Cancer / H. Rundqvist And R.s. Johnson. M. Celeste Simon, Editor. Includes Bibliographical References And Index. Front Matter....Pages i-x The HIF-2α-Driven Pseudo-Hypoxic Phenotype in Tumor Aggressiveness, Differentiation, and Vascularization....Pages 1-20 Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance....Pages 21-30 Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression....Pages 31-45 The Role of Hypoxia Regulated microRNAs in Cancer....Pages 47-70 Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration....Pages 71-103 Hypoxia-Inducible Factors as Essential Regulators of Inflammation....Pages 105-120 Hypoxia and Metastasis in Breast Cancer....Pages 121-139 Back Matter....Pages 141-143 Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration.