Dislocation and Degradation of Proteins from the Endoplasmic Reticulum (Current Topics in Microbiology and Immunology Book 300)

The present volume of Current Topics in Microbiology and Immunology c- tains seven chapters that illuminate various aspects of a protein’s genesis and terminal fate in the endoplasmic reticulum (ER). This area is of immediate medical relevance and has blossomed, to no small extent, because of the study of molecules central to the function of the immune system [immunogl- ulins, T cell receptors, major histocompatibility complex (MHC)-encoded products]. Similarly, the clever strategies used by bacteria or viruses to gain a foothold in the host and ensure their continued survival have uncovered altogether new cell biological principles. It is therefore ?tting that a special volume be devoted to the interplay between pathways of protein degradation in the ER and a wide variety of pathogens. The concept of quality control emerged with the appreciation that, in the case of multimeric glycoproteins, any unpaired glycoprotein subunit had great dif?culties leaving its site of synthesis—the ER—and was destroyed instead. Free immunoglobulin heavy chains were probably the earliest documented example of this kind, and were long known to cause pathology when their accumulation went unchecked. Increased knowledge of the biosynthetic pathways of glycoproteins allowed the identi?cation of the ER as an important site where such quality control decisions were made. The T cell receptor for antigen, long considered the paradigm of this mode of degradation, led the way in these early explorations. The Secretory Capacity Of A Cell Depends On The Efficiency Of Endoplasmic Reticulum-associated Degradation / M. Molinari And R. Sitia -- Recognition And Delivery Of Erad Substrates To The Proteasome And Alternative Paths For Cell Survival / A.a. Mccracken And J.l. Brodsky -- Cpy* And The Power Of Yeast Genetics In The Elucidation Of Quality Control And Associated Protein Degradation Of The Endoplasmic Reticulum / D.h. Wolf And A. Schäfer -- The Role Of The Ubiquination Machinery In Dislocation And Degradation Of Endoplasmic Reticulum Proteins / M. Kikkert, G. Hassink, And E. Wiertz -- The Role Of P97/cdc48p In Endoplasmic Reticulum-associated Degradation : From The Immune System To Yeast / S. Bar-nun -- The Ins And Outs Of Intracellular Peptides And Antigen Presentation By Mhc Class I Molecules / T. Groothuis And J. Neefjes -- Entry Of Protein Toxins Into Mammalian Cells By Crossing The Endoplasmic Reticulum Membrane : Co-opting Basic Mechanisms Of Endoplasmic Reticulum-associated Degradation / J.m. Lord, L.m. Roberts, And W.i. Lencer. E.j.h.j Wiertz, M. Kikkert (eds.). Includes Bibliographical References And Index. The Secretory Capacity of a Cell Depends on the Efficiency of Endoplasmic Reticulum-Associated Degradation....Pages 1-15 Recognition and Delivery of ERAD Substrates to the Proteasome and Alternative Paths for Cell Survival....Pages 17-40 CPY* and the Power of Yeast Genetics in the Elucidation of Quality Control and Associated Protein Degradation of the Endoplasmic Reticulum....Pages 41-56 The Role of the Ubiquitination Machinery in Dislocation and Degradation of Endoplasmic Reticulum Proteins....Pages 57-93 The Role of p97/Cdc48p in Endoplasmic Reticulum-Associated Degradation: From the Immune System to Yeast....Pages 95-125 The Ins and Outs of Intracellular Peptides and Antigen Presentation by MHC Class I Molecules....Pages 127-148 Entry of Protein Toxins into Mammalian Cells by Crossing the Endoplasmic Reticulum Membrane: Co-opting Basic Mechanisms of Endoplasmic Reticulum-Associated Degradation....Pages 149-168 Contains seven chapters that describe various aspects of a protein's genesis and terminal fate in the endoplasmic reticulum (ER). This area is of medical relevance since the malfunctioning of proper quality control during protein synthesis, and the lack of sufficient degradation of improper proteins from the ER forms the basis of human diseases