Discovery of Novel Natural Products with Therapeutic Potential (BIOTECHNOLOGY)

Although science has discovered effective drugs for many of the diseases that afflict mankind, many human health problems remain untreatable. The search for novel therapeutic agents is always ongoing. This book will describe some of the diverse sources of natural products, such as terrestrial and marine environments; and will review how research has increased knowledge of biological systems and human disease, leading to the design of targeted asssays, amenable to high volume screening. Content: BIOTECHNOLOGY , Page ii BIOTECHNOLOGY SERIES , Pages iii-iv Front Matter , Page v Copyright , Page vi CONTRIBUTORS , Pages vii-viii PREFACE , Pages xv-xvi , Vincent P. Gullo CHAPTER 1 - Aerobic Actinomycetes: A Continuing Source of Novel Natural Products , Pages 3-30 , Ann C. Horan CHAPTER 2 - Bacteria As a Source of Novel Therapeutics , Pages 31-47 , J.C. Hunter-Cevera, Angela Belt CHAPTER 3 - Potential of Fungi in the Discovery of Novel, Low-Molecular Weight Pharmaceuticals , Pages 49-80 , M.M. Dreyfuss, I.H. Chapela CHAPTER 4 - The Discovery of Drugs from Higher Plants , Pages 81-108 , A. Douglas Kinghorn CHAPTER 5 - The Discovery of Marine Natural Products with Therapeutic Potential , Pages 109-174 , Oliver J. McConnell, Ross E. Longley, Frank E. Koehn CHAPTER 6 - Mechanism-Based Screening for the Discovery of Novel Antifungals , Pages 177-221 , Donald R. Kirsch, Beth J. DiDomenico CHAPTER 7 - Strategies for Discovering Antiviral Agents from Natural Products , Pages 223-245 , E. Rozhon, R. Albin, J. Schwartz CHAPTER 8 - Mechanism-Based Screens in the Discovery of Chemotherapeutic Antibacterials , Pages 247-266 , Sunil Kadam CHAPTER 9 - Oncogene Function Inhibitors of Microbial Origin , Pages 267-280 , Kazuo Umezawa CHAPTER 10 - Screening Methodologies for the Discovery of Novel Cytotoxic Antitumor Agents , Pages 281-300 , Anna M. Casazza, Byron H. Long CHAPTER 11 - Hypocholesterolemic Agents , Pages 301-320 , Akira Endo CHAPTER 12 - Immunomodulators , Pages 321-346 , Masakuni Okuhara, Toru Kino CHAPTER 13 - Isolation and Purification of Secondary Metabolites , Pages 349-387 , James B. McAlpine, Jill E. Hochlowski CHAPTER 14 - Modern Spectroscopic Approaches to Structure Elucidation , Pages 389-444 , Otto D. Hensens INDEX , Pages 445-461 Although science has discovered effective drugs for many of the diseases that afflict mankind, many human health problems remain untreatable. The search for novel therapeutic agents is always ongoing. This book will describe some of the diverse sources
of natural products, such as terrestrial and marine environments; and will review how research has increased knowledge of biological systems and human disease, leading to the design of targeted asssays, amenable to high volume screening.

Describing some of the diverse sources of natural products for drug discovery, this book also outlines how research in molecular biology and biochemistry has increased knowledge of biological systems and human disease. This book describes some of the diverse sources of natural products.