Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes

It is uncertain how antiviral lymphocytes are activated in draining lymph nodes, the site where adaptive immune responses are initiated. Here, using intravital microscopy we show that after infection of mice with vaccinia virus (a large DNA virus) or vesicular stomatitis virus (a small RNA virus), virions drained to the lymph node and infected cells residing just beneath the subcapsular sinus. Naive CD8+ T cells rapidly migrated to infected cells in the peripheral interfollicular region and then formed tight interactions with dendritic cells, leading to complete T cell activation. Thus, antigen presentation at the lymph node periphery, not at lymphocyte exit sites in deeper lymph node venules, as dogma dictates, has a dominant function in antiviral CD8+ T cell activation. Where the action’s at......Page 2 TGFb betrays immunity fortumorigenesis......Page 3 In the news......Page 4 NF-κB is not alone......Page 5 Little pig, little pig, let me come in......Page 6 in brief......Page 7 in brief......Page 8 Autophagy lends a hand......Page 9 E proteins: manning the checkpoints......Page 10 TAMing inflammation......Page 11 New DCs found deep in the skin......Page 12 Evolving views on the genealogyof B cells......Page 13 Shaping and reshaping CD8+ T‐cellmemory......Page 25 Micromanagement of the immunesystem by microRNAs......Page 38 Phagocytosis and comparative innateimmunity: learning on the fly......Page 49 Regulation of immunologicalhomeostasis in the respiratory tract......Page 60 The reverse stop-signal model forCTLA4 function......Page 71 Erratum......Page 79