Dipeptidyl aminopeptidases basic science and clinical applications : [This book is devoted to the Second International Conference on Dipeptidyl Aminopeptidases held April 13-15, 2005 in Magdeburg, Germany

Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development. Front Matter....Pages 1-1 Peptide Substrates of Dipeptidyl Peptidases....Pages 3-18 Phosphorus-Containing Inhibitors of Proteolytic Enzymes....Pages 19-26 Biochemical Properties of Recombinant Prolyl Dipeptidases DPP-IV and DPP8....Pages 27-32 Prediction of Dipeptidyl Peptidase (DP) 8 Structure by Homology Modelling....Pages 33-42 Front Matter....Pages 43-43 Structure and Function in Dipeptidyl Peptidase IV and Related Proteins....Pages 45-54 Expression and Function of Dipeptidyl Peptidase IV and Related Enzymes in Cancer....Pages 55-62 DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis....Pages 63-72 In Vivo Effects of a Potent, Selective Dppii Inhibitor....Pages 73-85 Expression of Dipeptidyl Peptidase IV-Like Enzymes in Human Peripheral Blood Mononuclear Cells....Pages 87-91 Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activities....Pages 93-102 Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits an Unknown Post-Cysteine Cleavage Specificity....Pages 103-108 Distribution of Dipeptidyl Peptidase Iv-Like Activity Enzymes in Canine and Porcine Tissue Sections by RT-PCR....Pages 109-116 Front Matter....Pages 117-117 Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM)....Pages 119-133 Dipeptidyl Peptidase IV: A Molecular Switch of Vascular Actions of Neuropeptide Y....Pages 135-140 Front Matter....Pages 141-141 Dipeptidylpeptidase IV (DPIV) and Alanyl-Aminopeptidases (AAPs) as a New Target Complex for Treatment of Autoimmune and Inflammatory Diseases—Proof of Concept in a Mouse Model of Colitis....Pages 143-153 Dipeptidyl Peptidases and Inflammatory Bowel Disease....Pages 155-162 Possible Role of DP IV Inhibitors in Acne Therapy....Pages 163-167 Dipeptidyl Peptidase-IV Activity and/or Structure Homologs (DASH): Contributing Factors in the Pathogenesis of Rheumatic Diseases?....Pages 169-174 Front Matter....Pages 175-175 Dipeptidyl Peptidase IV (DP IV, CD26) and Aminopeptidase N (APN, CD13) as Regulators of T Cell Function and Targets of Immunotherapy in CNS Inflammation....Pages 177-186 CD26/DP IV in T Cell Activation and Autoimmunity....Pages 187-193 Front Matter....Pages 195-195 DPIV/CD26 and FAP in Cancer: A Tale of Contradictions....Pages 197-206 Type-II Transmembrane Prolyl Dipeptidases and Matrix Metalloproteinases in Membrane Vesicles of Active Endothelial Cells....Pages 207-212 Extra-Enzymatic Roles of DPIV and FAP in Cell Adhesion and Migration on Collagen and Fibronectin....Pages 213-222 Role of Neuropeptide Y and Dipeptidyl Peptidase IV in Regulation of Ewing’s Sarcoma Growth....Pages 223-229 The Role of CD26/DPP IV in Preservation of Early Pulmonary Graft Function....Pages 231-235 Dipeptidyl Aminopeptidases exert a modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. This book focuses on various topics, including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and more This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.