Difficult to Diagnose Rare Diffuse Lung Disease

Difficult to Diagnose Rare Diffuse Lung Disease presents the theoretical basis and practical aspects of differential diagnoses of rare lung diseases with the use of new method of probe-based confocal laser endomicroscopy (alveoscopy) of the distal respiratory region. Each chapter describes signs and symptoms of the disease and its typical and atypical manifestations. The book contains full color illustrations, including high-resolution histological microphotographs, CT-scans and confocal laser endomicroscopy images. In combination, these elements make this book an invaluable reference and guide for pulmonary researchers, pulmonologists, radiologists, and pathologists who wish to broaden their spectrum of knowledge in rare lung diseases. Highlights the new method of probe-based confocal laser endomicroscopy (alveoscopy) of the distal respiratory region, opening new horizons in the minimally invasive diagnosis of lung diseases Discusses current treatment strategies in accordance with clinical guidelines, including data from the latest clinical trials Presented in tabular format to aid in the diagnostic process Cover Difficult to Diagnose Rare Diffuse Lung Disease Copyright Contributors Preface Acknowledgments 1 HRCT and alveoloscopic assessment of diffuse lung disease References 2 Idiopathic interstitial pneumonias Idiopathic pulmonary fibrosis Risk factors Genetic risk factors Smoking Air pollutants Old age Gastroesophageal reflux Infection Pathogenesis Morphology Differential diagnosis of the histological pattern of UIP Clinical presentation and course Acute exacerbation of IPF Laboratory tests and biomarkers Functional diagnostics High-resolution computed tomography Bronchoalveolar lavage Probe-based confocal laser endomicroscopy of distal airways Diagnosis Differential diagnosis Complications of IPF Treatment Nonpharmacological treatment of IPF Prevention of acute exacerbations Prognosis References Nonspecific interstitial pneumonia Morphology Clinical presentation High-resolution computed tomography Bronchoscopy and bronchoalveolar lavage Probe-based confocal laser endomicroscopy of distal airways Differential diagnosis of idiopathic NSIP Treatment and prognosis References Cryptogenic organizing pneumonia Morphology Clinical presentation Diagnosis High-resolution computed tomography Differential diagnosis Treatment and prognosis References Desquamative interstitial pneumonia Morphology Clinical presentation Diagnosis High-resolution computed tomography Differential diagnosis Treatment and prognosis References Respiratory bronchiolitis–associated interstitial lung disease Morphology Clinical presentation Diagnosis Radiological pattern Differential diagnosis Treatment and prognosis References Acute interstitial pneumonia Morphology Clinical presentation Diagnosis Computed tomography Differential diagnosis Treatment and prognosis References Lymphoid interstitial pneumonia Morphology Clinical presentation Diagnosis High-resolution computed tomography Differential diagnosis Treatment and prognosis References Idiopathic pleuroparenchymal fibroelastosis Morphology Clinical presentation and course Diagnosis HRCT characteristics Differential diagnosis Treatment and prognosis References 3 Hypersensitivity pneumonitis Pathogenesis Morphology Differential diagnosis of HP according to lung biopsy data Clinical presentation and course Diagnosis High-resolution computed tomography Probe-based confocal laser endomicroscopy (pCLE) Differential diagnosis Treatment and prognosis References 4 Airspace-predominant diseases Pulmonary alveolar proteinosis Clinical presentation Diagnosis Probe-based confocal laser endomicroscopy of distal airways Differential diagnosis Treatment and prognosis References Alveolar microlithiasis Morphology Clinical presentation Diagnosis Radiography Computed tomography Differential diagnosis Treatment References Diffuse alveolar hemorrhage Morphology Clinical presentation Diagnosis High-resolution computed tomography Differential diagnosis Treatment and prognosis References 5 Amyloidosis Morphology Clinical presentation Diagnosis High-resolution computed tomography Differential diagnosis Treatment References 6 Granulomatosis with polyangiitis Morphology Clinical presentation Diagnosis Computed tomography Differential diagnosis Treatment and prognosis References 7 Eosinophilic lung disease Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) Morphology Clinical presentation Diagnostic tests Computed tomography Probe-based confocal laser endomicroscopy Diagnostic criteria Treatment and prognosis References Idiopathic chronic eosinophilic pneumonia Morphology Clinical presentation Radiological imaging Bronchoalveolar lavage (BAL) Treatment and prognosis References Differential diagnosis of eosinophilic pulmonary diseases References 8 Lung disease related to connective tissue diseases Respiratory involvement in rheumatoid arthritis Morphology Clinical presentation High-resolution computed tomography RA-ILD Nodular lesions Caplan syndrome Pleural lesions Lower airway abnormalities Vascular lesions Differential diagnosis Treatment References Systemic sclerosis-related interstitial lung disease Morphology Clinical presentation Laboratory diagnostics High-resolution computed tomography Probe-based confocal laser endomicroscopy (pCLE) Differential diagnosis Treatment References Lung disease in polymyositis/dermatomyositis Morphology Clinical presentation and diagnosis High-resolution computed tomography Differential diagnosis Treatment References Lung disease in systemic lupus erythematosus Morphology Clinical presentation Diagnosis Computed tomography Differential diagnosis Treatment References Pulmonary disease in Sjögren syndrome Clinical presentation Diagnosis Radiological signs Differential diagnosis Treatment References 9 Diffuse cystic lung disease Pulmonary Langerhans cell histiocytosis Morphology Clinical presentation Radiological imaging Bronchoalveolar lavage and lung biopsy Probe-based confocal laser endomicroscopy Diagnosis Treatment and prognosis References Lymphangioleiomyomatosis Morphology Clinical presentation Biomarker Radiological imaging Probe-based confocal laser endomicroscopy Diagnosis Treatment and prognosis References Birt-Hogg-Dubé syndrome References Differential diagnosis of cystic diseases References References 10 Tumors that mimic diffuse parenchymal lung disease Primary malignant lung tumors Pulmonary adenocarcinoma Morphology Clinical presentation Radiological findings Differential diagnosis References Primary lung lymphoma Diagnosis and differential diagnosis Computed tomography References Metastatic lung disease References 11 Drug-induced pulmonary diseases Amiodarone-induced lung disease (AILD) Clinical presentation Diagnosis High resolution computed tomography Differential diagnosis Treatment and prognosis Methotrexate-induced pneumonitis Diagnosis High-resolution computed tomography Differential diagnosis Treatment and prognosis Lung damage by anticancer drugs References Abbreviations Index A B C D E F G H I K L M N O P R S T U V W Back Cover __Difficult to Diagnose Rare Diffuse Lung Disease__ presents the theoretical basis and practical aspects of differential diagnoses of rare lung diseases with the use of new method of probe-based confocal laser endomicroscopy (alveoscopy) of the distal respiratory region. Each chapter describes signs and symptoms of the disease and its typical and atypical manifestations. The book contains full color illustrations, including high-resolution histological microphotographs, CT-scans and confocal laser endomicroscopy images. In combination, these elements make this book an invaluable reference and guide for pulmonary researchers, pulmonologists, radiologists, and pathologists who wish to broaden their spectrum of knowledge in rare lung diseases.