Diet And Cancer: Molecular Mechanisms Of Interactions (advances In Experimental Medicine And Biology)

The fifth of the annual research conferences of the American Institute for Cancer Research was held September l-2, 1994, at the L'Enfant Plaza Hotel in Washington, DC. Appropriately, in view of current directions in research, the theme was "Diet and Cancer: Molecular Mechanisms of Interactions". This proceedings volume contains chapters from the platform presentations and abstracts from the poster session held on the end of the first day. The subtopics for the tl;rree sessions held were "Retinoids, Vitamins A and Din Cancer Prevention and Therapy," "Choline and Lipids: Signal Transduction, Gene Expression and Growth Regulation," and "Dietary Factors and Regulation of Oncogenes, Growth and Differentiation. " A general overview on vitamins A and D emphasized that A and D, in addition to their established roles in vision, reproduction, and bone mineral homeostasis, may play significant roles in regulating cell function. Vitamin A metabolites, trans-retinoic acid and 9-cis-retinoic acid, regulate growth and differentiation. Furthermore, vitamin A­ deprived animals were more susceptible to both spontaneous and carcinogen-induced tumors. Epidemiological studies showed a correlation between low A intake and higher incidences of certain types of human cancers. Conversely, all-trans retinoic acid is useful in treatment and control of certain types of cancer. Physiologically, Vitamin D is converted to the active form, l ,25-dihydroxyvitamin D (VD). VD regulates hormone production and secretion, myocardial contractility, vascu­ 3 3 3 lar tone, and growth inhibition and differentiation. Front Matter....Pages i-xiv Use of Vitamins A and D in Chemoprevention and Therapy of Cancer: Control of Nuclear Receptor Expression and Function....Pages 1-15 Vitamin A Chemoprevention of Lung Cancer....Pages 17-29 Human Cervical Cancer....Pages 31-44 Role of Apoptosis in the Growth Inhibitory Effects of Vitamin D in MCF-7 Cells....Pages 45-52 Vitamin D and Prostate Cancer....Pages 53-63 Choline and Hepatocarcinogenesis in the Rat....Pages 65-74 Dietary Effects on Gene Expression in Mammary Tumorigenesis....Pages 75-83 Effect of Dietary Fatty Acids on Gene Expression in Breast Cells....Pages 85-95 Lipotrope Deficiency and Persistent Changes in DNA Methylation....Pages 97-106 Methionine Deprivation Regulates the Translation of Functionally-Distinct c-Myc Proteins....Pages 107-116 Progressive Loss of Sensitivity to Growth Control by Retinoic Acid and Transforming Growth Factor-Beta at Late Stages of Human Papillomavirus Type 16-Initiated Transformation of Human Keratinocytes....Pages 117-135 Short-Chain Fatty Acids and Molecular and Cellular Mechanisms of Colonic Cell Differentiation and Transformation....Pages 137-148 Fish Oil and Cell Proliferation Kinetics in a Mammary Carcinoma Tumor Model....Pages 149-156 Abstracts....Pages 157-218 Back Matter....Pages 219-222 'The high quality of the research summarized in this volume is a tribute to the excellent review process that the AICR has established to disseminate funds in the area of diet, nutrition, and cancer prevention or treatment ... this book is worthy of being passed around the laboratory group and should stimulate students, postdoctoral fellows, and principal investigators interested in the application of cellular and molecular techniques to the field of nutrition and cancer.'-The Quarterly Review of Biology