Diastolic Relaxation of the Heart : The Biology of Diastole in Health and Disease

Numerous studies have documented the importance of diastolic dysfunction in heart disease. Now, providing cardiologists with the most current information available on the subject, the editors have pulled together contributions from an impressive array of top researchers and compiled them into one comprehensive, carefully edited source, __Diastolic Relaxation of the Heart, Second Edition: The____Biology of Diastole in Health and Disease__. This brand new Second Edition, based on a recent meeting, includes such topics as: * molecular biology of relaxation; * consequences of altered gene expression; * impaired relaxation in experimental models (ischemia and hypoxia, and hypertrophy and failure); * diastolic dysfunction in the diseased human heart. __Diastolic Relaxation of the Heart, Second Edition: The Biology of____Diastole in Health and Disease__, the successor to the editors' bestselling work on the same subject, published in 1987 - belongs on the shelf of every practising cardiologist. It will also be an invaluable addition to the library of scientists researching the effects of diastole on heart function. Front Matter....Pages i-xiii Front Matter....Pages 1-1 Overview: The Molecular Phenotype of Normal and Impaired Relaxation....Pages 3-6 Regulation of Gene Expression in the Failing Myocardium: Evidence for a Heart Failure Gene Program....Pages 7-16 Sarcoplasmic Reticulum Gene Expression in Human Heart Failure....Pages 17-23 Molecular Aspects of the Control of Myocardial Relaxation....Pages 25-32 Molecular Physiology of Ventricular Hypertrophy....Pages 33-40 Front Matter....Pages 41-41 Regulatory Proteins and Diastolic Relaxation....Pages 43-53 Intracellular Free Calcium in Hypertrophy and Failure....Pages 55-64 A Molecular Biophysical Approach to Contraction and Relaxation....Pages 65-71 On the Relations among ATP Hydrolysis, Cation Accumulation, and Diastolic Dysfunction....Pages 73-78 Adrenergic Signal Transduction in Congestive Heart Failure: Effects on Diastole....Pages 79-90 Cardiac Renin-Angiotensin System in Cardiac Hypertrophy and Failure....Pages 91-99 Altered Force-Frequency Relation and Excitation-Contraction Coupling in the Failing Human Heart: Relevance of SR-Ca 2+ -ATPase Protein Levels....Pages 101-108 Front Matter....Pages 109-109 Effects of Hypoxia and Ischemia on Intracellular Calcium and Relaxation: Studies in the Aequorin-Loaded Whole Heart Model....Pages 111-123 Diastolic Dysfunction During Ischemia: Role of Glycolytic ATP Generation....Pages 125-134 Does Calcium Overload Adequately Explain Diastolic Dysfunction During Metabolic Inhibition?....Pages 135-148 Mechanisms of Relaxation: Perspectives from Studies in Single Cardiac Cells....Pages 149-165 Modulation of Diastolic Dysfunction in the Intact Heart....Pages 167-176 Altered Load: An Important Component of Impaired Diastolic Function in Hypertension and Heart Failure....Pages 177-185 Endothelial-Ventricular Interaction in Normal and Diseased Hearts....Pages 187-191 Front Matter....Pages 193-193 Diastolic Dysfunction in Experimental Heart Failure....Pages 195-202 Front Matter....Pages 193-193 Interplay of Hypertrophy and Myocardial Ischemia....Pages 203-211 Myocardial Fibrosis: Structural Basis for Diastolic Dysfunction....Pages 213-220 Coronary Venous Pressure and Left Ventricular Diastolic Distensibility....Pages 221-231 Pericardium and Ventricular Interaction: Effects on Diastolic Filling....Pages 233-241 Diastolic Dysfunction in Tachycardia-Induced Heart Failure....Pages 243-263 Diastolic Abnormalities in Low-Flow and Pacing Tachycardia-Induced Ischemia in Isolated Rat Hearts—Modification by Calcium Antagonists....Pages 265-274 Front Matter....Pages 275-275 Diastolic Dysfunction and Myocardial Energetics....Pages 277-282 Diastolic Dysfunction in Chronic Pressure and Volume Overload....Pages 283-288 Sustained Diastolic Dysfunction Following Severe Exercise-Induced Ischemia in Patients with Coronary Disease....Pages 289-294 Exercise Intolerance in Patients with Heart Failure: Role of Diastolic Dysfunction....Pages 295-302 Comparative Effects of Ischemia and Hypoxemia on Left Ventricular Diastolic Function in Humans....Pages 303-321 Determinants of Left Ventricular Diastolic Filling: Insights from Echo-Doppler....Pages 323-340 Back Matter....Pages 341-348 Numerous studies have documented the importance of diastolic dysfunction in heart disease. Now, providing cardiologists with the most current information available on the subject, the editors have pulled together contributions from an impressive array of top researchers and compiled them into one comprehensive, carefully edited source, Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease . This brand new Second Edition, based on a recent meeting, includes such topics as: molecular biology of relaxation; consequences of altered gene expression; impaired relaxation in experimental models (ischemia and hypoxia, and hypertrophy and failure); diastolic dysfunction in the diseased human heart. Diastolic Relaxation of the Heart, Second Edition: The Biology of Diastole in Health and Disease , the successor to the editors' bestselling work on the same subject, published in 1987 - belongs on the shelf of every practising cardiologist. It will also be an invaluable addition to the library of scientists researching the effects of diastole on heart function.